Korean J Otolaryngol-Head Neck Surg.  2006 Dec;49(12):1145-1150.

Allele Distribution of Human Surfactant Protein A in Otitis Media with Effusion

• Han KY
• Oh CH
• Jang HS
• Kim JM
• Kim SW
• Oh MH

Abstract

BACKGROUND AND OBJECTIVES
Surfactant protein A (SP-A) which plays a role in the innate host defense of lung is also expressed in Eustachian tube. However the genes underlying the susceptibility to otitis media with effusion (OME) are known insufficiently. The current study attempts to evaluate the difference in the allele distribution of SP-A1 and SP-A2 between normal subjects and subjects with otitis media with effusion.
SUBJECTS AND METHOD
PCR-cRFLP-based methodology was used to detect SP-A genotypes in the 38 children with OME, and in the 55 normal newborns for control.
RESULTS
The frequencies of specific genotypes such as 6A(2), 1A(2) were increased in OME group, but the frequency of 6A3 was increased in control group.
CONCLUSION
It is presumed that SP-A alleles may be inductive (6A(2), 1A(2)) or protective (6A(3)) factors for OME. Specific genoytypes of SP-A may be an important determinant for the predisposition to OME.

Keyword

Otitis media with effusion; Surfactant protein A; PCR-cRFLP

MeSH Terms

Alleles*
Child
Eustachian Tube
Genotype
Humans*
Infant, Newborn
Lung
Otitis Media with Effusion*
Otitis Media*
Otitis*
Pulmonary Surfactant-Associated Protein A*
Pulmonary Surfactant-Associated Protein A