J Korean Neurol Assoc.  2004 Apr;22(2):127-133.

Clinical and Electrophysiologic Features of Peripheral Neuropathy in Churg-Strauss Syndrome

• Seok JI
• Bae JS
• Joo EY
• Min TH
• Choi DC
• Kim BJ

Abstract

BACKGROUND
Churg-Strauss syndrome (CSS) is characterized by disseminated vasculitis and eosinophilia in patients with asthma. This study was performed to delineate the characteristics of peripheral neuropathy and to identify the factors associated with the severity of neurologic disability. METHODS: We reviewed the medical records of 12 consecutive patients with Churg-Strauss syndrome who had been diagnosed at Samsung Medical Center. The diagnosis of CSS was based on the American college of Rheumatology 1990 criteria. RESULTS: Of the 12 patients, 9 had neurologic involvement. Six had neurologic symptoms as presenting manifestations. All neurologic manifestations were peripheral neuropathy; 5 had multiple mononeuropathy, 2 had distal symmetric polyneuropathy, and 2 had mononeuropathy. Neurologic disability score depended on the rapidity of steroid treatment. CONCLUSIONS: Neurologic involvement is common and develops early in patients with CSS, usually manifesting as peripheral neuropathy. Neurologic disability score showed that early steroid therapy was related with less neurologic disability.

Keyword

Churg-Strauss syndrome; Peripheral neuropathy; Corticosteroid

MeSH Terms

Asthma
Churg-Strauss Syndrome*
Diagnosis
Eosinophilia
Humans
Medical Records
Mononeuropathies
Neurologic Manifestations
Peripheral Nervous System Diseases*
Polyneuropathies
Rheumatology
Vasculitis