Korean J Ophthalmol.  2013 Feb;27(1):55-57. 10.3341/kjo.2013.27.1.55.

Conjunctival Hypertrophic Scar Following Cryotherapy for Retinopathy of Prematurity

• Lyu IJ
• Sa HS
• Woo KI
• Kim YD

• KMID: 1501798
• DOI: http://doi.org/10.3341/kjo.2013.27.1.55

Abstract

A 6-year-old boy was referred to our hospital with symblepharon and lateral canthal deformity in both eyes, which developed 6 years ago. The patient was born at 27 weeks gestation. He had received cryotherapy for retinopathy of prematurity. One month after cryotherapy, he developed a conjunctival scar with symblepharon in both eyes and underwent symblepharon lysis at another hospital 5 years prior. Ocular examination revealed an extensive conjunctival hypertrophic scar with symblepharon and limitation of extraocular movements. An excisional biopsy, lateral canthoplasty, and symblepharon lysis with conjunctival autograft from the contralateral eye were performed in the left eye. Histopathologic examination revealed diffuse proliferation and infiltration of collagenous tissue.

Keyword

Cicatrix; Cryotherapy; Hypertrophic; Retinopathy of prematurity; Symblepharon

MeSH Terms

Biopsy
Child
Cicatrix, Hypertrophic/diagnosis/*etiology
Conjunctiva/pathology
Conjunctival Diseases/diagnosis/*etiology
Cryotherapy/*adverse effects
Diagnosis, Differential
Follow-Up Studies
Humans
Male
Retinopathy of Prematurity/*therapy

Figure

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  Fig. 1 Anterior segment photographs showing lateral canthal deformity, symblepharon, and a conjunctival scar involving almost 360 degrees of peripheral cornea in the left eye.

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  Fig. 2 Histopathologic examination reveals diffuse proliferation and infiltration of the collagenous tissue. These findings are consistent with hypertrophic scar. H&E, (A) ×100, (B) ×400.

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  Fig. 3 (A) Preoperative photograph showing a temporal conjunctival scar with lateral canthal deformity of both eyes. (B,C) Photograph taken 1 year after surgery showing no recurrence and good cosmesis.

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