Korean J Hematol.  2008 Dec;43(4):247-252. 10.5045/kjh.2008.43.4.247.

Metachronous Mantle Cell Lymphoma with Leukemic Presentation in a Patient with Early Gastric Cancer: A Case Report

• Eo WK
• Ahn KJ
• Lee WI
• Lim SJ
• Jeong JS

• KMID: 1485083
• DOI: http://doi.org/10.5045/kjh.2008.43.4.247

Abstract

We report here on a case of metachronous second primary non-Hodgkin's lymphoma (NHL) that was diagnosed 6 years after performing subtotal gastrectomy for treating early gastric cancer (EGC). The subtype analysis revealed mantle cell lymphoma (MCL) of the blastic variant with a leukemic presentation, which was composed of mixed small and medium-sized cells. The immunohistochemical staining for cyclin-D1 was positive. The cytogenetic study revealed t(4;6). In Korea, the risk of developing a second primary cancer following gastric cancer was reported to be less than 3.4%, and NHL comprised less than 6.3% of this second primary cancer. Furthermore, MCL represents about 2% of all lymphomas in Korea. To the best of our knowledge, this is the first report of metachronous primary MCL with a leukemic presentation following curative resection of EGC.

Keyword

Gastric cancer; Metachronous second primary neoplasms; Mantle cell lymphoma; Leukemia

MeSH Terms

Cytogenetics
Gastrectomy
Humans
Korea
Leukemia
Lymphoma
Lymphoma, Mantle-Cell
Lymphoma, Non-Hodgkin
Neoplasms, Second Primary
Stomach Neoplasms