Hanyang Med Rev.
2010 Aug;30(3):238-245. 10.7599/hmr.2010.30.3.238.
Eosinophil and Tissue-invasive Parasitic Helminth
- Affiliations
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- 1Department of Environmental Medical Biology and Institute of Tropical Medicine, and Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, Seoul, Korea. myeong@yuhs.ac
- KMID: 1460259
- DOI: http://doi.org/10.7599/hmr.2010.30.3.238
Abstract
- Eosinophils are primarily tissue resident cells, and play important roles in host's immune responses and maintenance of chronic infection during infection with tissue-invasive parasitic helminth. Such parasite secretes particular molecules to evade eosinophil-mediated helminthotoxicity. Continuous competition between eosinophil and parasite leads to stable equilibria between them. Recent evidence provides a concept that not only eosinophils contribute to parasite's survival but also parasite modulates host's immune response. Therefore, it is important to know complex interrelationship between eosinophil and parasite to understand how gently parasite talk to eosinophils and how carefully eosinophils listen to parasite's voice. In this regard, this review examin papers about eosinophil-mediated tissue inflammatory responses in response to helminthic parasite.
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