Hanyang Med Rev.  2010 Aug;30(3):232-237. 10.7599/hmr.2010.30.3.232.

Recent Advances in Serodiagnosis for Clonorchiasis

• Kim TI
• Hong SJ

• KMID: 1460258
• DOI: http://doi.org/10.7599/hmr.2010.30.3.232

Abstract

Human clonorchias is a major parasitic infection and estimated about 1.4 million people to be infected with this parasite in Korea now. Clonorchiasis is a chronic disease debilitating inhabitants and threatening their health in endemic areas. Early diagnosis and treatment of clonorchis-infections are crucial. As a standard diagnostic method, the microscopic stool examination and identification of the egg has been employed. Nowadays needs are serodiagnostic kits of more rapid, simple and convenient formats. Serodiagnostic methods using antigenic proteins, in crude or molecularly defined forms, of Clonorchis sinensis could be alternatives for diagnosis of C. sinensis-infections. Serodiagnostic methods could be employed for large scale diagnosis to screen out infected with stress on false negatives of light worm-burden cases. To alleviate these obstacles, antigenic proteins of high specificity and moderate sensitivity have been identified and available in molecularly defined forms. Recently, a rapid diagnostic test was developed for serodiagnosis of C. sinensis-infections. Multiple antigen mixtures are expected to be formulated using these defined antigenic proteins and to escalate rapid diagnostic tests to those of high specificity and sensitivity for serodiagnosis of C. sinensis-infections.

Keyword

Clonorchis sinensis; Antigen; Clonorchiasis; Serodiagnosis; Rapid diagnostic test

MeSH Terms

Chronic Disease
Clonorchiasis
Clonorchis sinensis
Diagnostic Tests, Routine
Early Diagnosis
Humans
Korea
Light
Ovum
Parasites
Proteins
Sensitivity and Specificity
Serologic Tests
Proteins