Korean J Dermatol.  2012 Apr;50(4):367-370.

Cutaneous Angiosarcoma Developed at Site of Herpes Zoster Scar: Wolf's Isotopic Response

• Cho HH
• Paik SH
• Byun HJ
• Cho KH

Abstract

Angiosarcoma is a rare malignant vascular tumor of endothelial origin. It can involve any organ, including the skin, soft tissue, liver, bone, spleen, and orbit. Skin is the most frequent site of primary angiosarcoma, however, metastatic skin involvement of angiosarcoma is exceptional. Wolf's isotopic response implies that the new disease appeared at the site of an already healed skin disease. Several types of cutaneous lesions have been described, occurring within cleared cutaneous herpes zoster, or herpes simplex lesions. These lesions include comedones, granulomatous diseases, tinea, furunculosis, wart, psoriasis, pseudolymphoma, leukemia, lymphoma, basal cell carcinoma, squamous cell carcinoma and cutaneous metastases, from internal carcinoma. Herein, we report a case of cutaneous angiosarcoma of unknown origin that has developed at the site of a scar, after herpes zoster in a 79-year-old man as isotopic response.

Keyword

Angiosarcoma; Herpes zoster; Wolf's isotopic response

MeSH Terms

Aged
Carcinoma, Basal Cell
Carcinoma, Squamous Cell
Cicatrix
Furunculosis
Hemangiosarcoma
Herpes Simplex
Herpes Zoster
Humans
Leukemia
Liver
Lymphoma
Methylmethacrylates
Neoplasm Metastasis
Orbit
Polystyrenes
Pseudolymphoma
Psoriasis
Skin
Skin Diseases
Spleen
Tinea
Warts
Methylmethacrylates
Polystyrenes