Korean J Dermatol.
2013 May;51(5):360-363.
Circumscribed Acral Hypokeratosis with Expression of Human Papillomavirus High-risk Type 16, 18
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- 1Department of Dermatology, School of Medicine and Medical Research Institute, Chungbuk National University, Cheongju, Korea. jyl@chungbuk.ac.kr
Abstract
- Circumscribed acral hypokeratosis (CAH) is a rare disorder characterized by a well-circumscribed and erythematous depressed patch on the palm or sole. It usually presents as an asymptomatic, solitary, long-standing lesion in middle-aged to elderly women. Histologically, it has a characteristic stair-like configuration between normal and involved skin with an abrupt thinning of the horny layer and a decreased granular layer. Although the pathogenesis of CAH is not well established, several hypotheses were proposed. To our knowledge, there have been only two cases to document HPV in a single lesion of CAH. Herein, we report the third case of circumscribed acral hypokeratosis with expression of human papillomavirus, high-risk type 16, 18.
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