Korean J Dermatol.  2010 Apr;48(4):296-299.

A Case of Guttate Psoriasis after Treatment with IFN-alpha

  • 1Department of Dermatology, College of Medicine, Soonchunhyang University, Seoul, Korea. snolomas@hosp.sch.ac.kr


Psoriasis is considered to be an autoimmune disease of abnormal keratinocyte proliferation induced by T lymphocytes. An association with several cytokines has been suggested. Interferon (IFN) is a cytokine secreted by virus-infected cells and has the ability to prevent further infection of cells that were exposed to it. It has therefore been used as a therapeutic agent for many chronic viral diseases such as chronic hepatitis C. Recently, however, IFN has also been considered to be a triggering factor in the development of psoriasis. We describe an 18-year-old woman presenting with guttate psoriasis, who suffered soft tissue sarcoma and underwent chemotherapy containing IFN-alpha. This is possibly the first case of guttate psoriasis associated with IFN-alpha in the Korean literature.


Guttate psoriasis; Interferon alpha
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