J Vet Sci.  2004 Jun;5(2):147-150.

Idiopathic canine polyarteritis in control beagle dogs from toxicity studies

• Son WC

Abstract

It is sometimes difficult to assess the relevance of polyarteritis with treatment-related lesions in dog toxicity studies, as number of dogs used in a toxicity study is small and the lesions are similar to those seen in spontaneous diseases. This report is intended to establish a general profile of idiopathic canine polyarteritis in beagle dogs. Data from a total of 40 dog studies including 4-, 13- or 52- weeks studies conducted between 1990 and 2003 at Huntingdon Life Sciences, UK, were collected and analysed. There was no death by this disease and also no prominent clinical signs related to this disease. Histologically, males tended to develop polyarteritis more frequently than in females and epididymis is the most probable tissues, followed by thymus and heart. Dogs in two studies showed higher incidences of these lesions, whereas animals in the other studies did not exhibited, suggesting that genetic predilection plays an important role in this disease.

Keyword

beagle; dog; pain; polyarteritis

MeSH Terms

Animals
Dog Diseases/*pathology
Dogs
Drug Evaluation, Preclinical
Epididymis/pathology
Female
Male
Myocardium/pathology
Polyarteritis Nodosa/pathology/*veterinary
Retrospective Studies
Sex Distribution
Thymus Gland/pathology
Tissue Distribution