Korean J Ophthalmol.  2010 Feb;24(1):62-64. 10.3341/kjo.2010.24.1.62.

One Sister and Brother with Mirror Image Myopic Anisometropia

• Park SJ
• Kim JY
• Baek SH
• Kim ES
• Kim US

• KMID: 1098797
• DOI: http://doi.org/10.3341/kjo.2010.24.1.62

Abstract

We report a case of one sister and brother with mirror image myopic anisometropia. One sister and brother complained visual disturbance. The sister was 10 years 11 months old, and brother was 8 years 4 months old. Full ophthalmic examinations were performed, including slit lamp examination, intraocular pressure, keratometry, anterior chamber depth, axial length, fundus examination and the cycloplegic refraction. The cycloplegic refractive power was -15.50 dpt cyl.+4.50 dpt Ax 85degrees (right eye), -1.00 dpt cyl.+0.50 dpt Ax 90degrees (left eye) in the sister; -1.75 dpt cyl.+2.25 dpt Ax 90degrees (right eye), -9.50 dpt cyl.+4.00 dpt Ax 80degrees (left eye) in the brother. The co-occurrence of severe myopic anisometropia in a sister and brother is extremely rare. The present case suggests that severe myopic anisometropia may be related by genetic inheritance.

Keyword

Amblyopia; Anisometropia; Genetic inheritance

MeSH Terms

Anisometropia/*etiology/*genetics/physiopathology/therapy
Child
Female
Humans
Male
Myopia/*complications/*genetics/physiopathology/therapy
Refraction, Ocular
*Siblings
Visual Acuity

Reference

1. Abrahamsson M, Fabian G, Sjŏstrand J. Changes in astigmatism between the ages of 1 and 4 years: a longitudinal study. Br J Ophthalmol. 1988. 72:145–149.

2. Abrahamsson M, Fabian G, Sjŏstrand J. A longitudinal study of a population based sample of astigmatic children. II. The changeability of anisometropia. Acta Ophthalmol (Copenh). 1990. 68:435–440.

3. Abrahamsson M, Fabian G, Andersson AK, Sjŏstrand J. A longitudinal study of a population based sample of astigmatic children. I. Refraction and amblyopia. Acta Ophthalmol (Copenh). 1990. 68:428–434.

4. Abrahamsson M, Sjŏstrand J. Natural history of infantile anisometropia. Br J Ophthalmol. 1996. 80:860–863.

5. Teikary JM, O'Donnell J, Kaprio J, Koskenvuo M. Impact of heredity in myopia. Hum Hered. 1991. 41:151–156.

6. von Noorden GK. Amblyopia: a multidisciplinary approach. Proctor lecture. Invest Ophthalmol Vis Sci. 1985. 26:1704–1716.

7. Pediatric Eye Disease Investigator Group. A randomized trial of atropine vs. patching for treatment of moderate amblyopia in children. Arch Ophthalmol. 2002. 120:268–278.

8. Almeder LM, Peck LB, Howland HC. Prevalence of anisometropia in volunteer laboratory and school screening populations. Invest Ophthalmol Vis Sci. 1990. 31:2448–2455.

9. Okamoto F, Nonoyama T, Hommura S. Mirror image myopic anisometropia in two pairs of monozygotic twins. Ophthalmologica. 2001. 215:435–438.

10. Rosenthal AR, von Noorden GK. Clinical findings and therapy in unilateral high myopia associated with amblyopia. Am J Ophthalmol. 1971. 71:873–879.

11. Sorsby A, Sgeridan M, Leary GA. Refraction and its components in twins. 1962. London: Her Majesty's Stationery Office;1–43.