J Vet Sci.  2007 Sep;8(3):229-236. 10.4142/jvs.2007.8.3.229.

Retrospective study of canine cutaneous tumors in Korea

Affiliations
  • 1Department of Veterinary Pathology, College of Veterinary Medicine, Seoul National University, Seoul 151-742, Korea. daeyong@snu.ac.kr
  • 2Department of Veterinary Medicine, Cheju National University, Jeju 690-756, Korea
  • 3School of Veterinary Medicine, Kangwon National University, Chuncheon 200-701, Korea
  • 4Department of Laboratory Animal Medicine, College of Veterinary Medicine, Konkuk University, Seoul 143-701, Korea

Abstract

Over the 42 month period from January 2003 to June2006, a total of 2,952 canine biopsy specimens werereceived from the Veterinary Medical Teaching Hospitalof Seoul National University and from veterinary practitionersacross the nation. Out of these, 748 (25.34%) cases werediagnosed as canine cutaneous tumors in the Departmentof Veterinary Pathology, College of Veterinary Medicine,Seoul National University, Korea. Thirty-eight differenttypes of cutaneous tumors were identified and categorizedinto epithelial and melanocytic tumors (56.95%), mesenchymaltumors (38.90%), and hematopoietic tumors (4.14%)located in the skin. Among these, 69.25% were benign and30.74% were malignant. The top ten most frequentlydiagnosed cutaneous tumors were epidermal and follicularcysts (12.70%), lipoma (11.36%), mast cell tumors (8.82%),cutaneous histiocytoma (7.49%), basal cell tumors (6.82%),sebaceous gland adenoma (6.68%), sebaceous glandhyperplasia (5.08%), hepatoid gland adenoma (3.61%),apocrine adenocarcinoma (3.07%), and fibroma (2.81%),in order of prevalence. They comprised 68.45% of allcutaneous tumors. These top ten cutaneous tumors weredistributed on the trunk (30.08%), head and neck(20.9%), extremities (19.14%), anal and perianal area(8.59%), and tail (3.91%). The age of the dogs with the tenmost frequent tumors had a mean age of 8.3 years, with arange of 2 months to 19 years. When all types of tumorswere considered together in the entire population, therewas no difference in incidence according to sex.

Keyword

benign; biopsy; cutaneous tumors; histopathol-ogy; malignant

MeSH Terms

Animals
Biopsy/veterinary
Dog Diseases/epidemiology/*pathology
Dogs
Female
Immunohistochemistry/veterinary
Korea/epidemiology
Male
Prevalence
Retrospective Studies
Skin Neoplasms/epidemiology/pathology/*veterinary

Figure

  • Fig. 1 Photomicrographs of cutaneous and mesenchymal tumors of canine. (A) Basal cell tumor, medusoid subtype. Note neoplastic cells aggregated in the center and cords stream outward in medusa pattern. H&E stain. bar = 200 µm. (B) Epidermal cyst. Note a wall of squamous epithelial cells containing keratinous content in its lumen. H&E stain. bar = 200 µm. (C) Hepatoid gland adenoma. Note well differentiated hepatoid cells arranged in anastomosing trabeculae. The individual neoplastic cells resemble hepatocytes. H&E stain. bar = 100 µm. (D) Hemangiopericytoma. Note neoplastic cells demonstrate the perivascular whorled pattern and storiform pattern. H&E stain. bar = 100 µm. (E) Cutaneous histiocytoma. Note compact sheet of neoplastic histiocytes replacing adnexa and infiltrating into the epidermis. H&E stain. bar = 80 µm. (F) Mast cell tumor. Note a dense sheet of neoplastic mast cells causing collagenolysis. Aggregates of eosinophils are also present. H&E stain. bar = 80 µm. (G) Mast cell tumor. Fine metachromatic granules are dispersed in the cytoplasm. Toluidine blue stain. bar = 20 µm. (H) Fibrosarcoma. Note abundant collagen bundles. Masson's trichrome stain. bar = 20 µm. (I) Peripheral nerve sheath tumor. Spindloid neoplastic cells arranged in interwoven bundles are positive for vimentin. Avidin-biotin peroxidase complex method. bar = 20 µm.


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Ji-Won Choi, Hun-Young Yoon, Soon-Wuk Jeong
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