J Vet Sci.  2006 Dec;7(4):401-403. 10.4142/jvs.2006.7.4.401.

Multiple intestinal lymphomatous polyposis in a Jindo dog

• Jeong DH
• Do SH
• Hong IH
• Yang HJ
• Yuan DW
• Choi DH
• Jeong KS

• KMID: 1089491
• DOI: http://doi.org/10.4142/jvs.2006.7.4.401

Abstract

A male, 5-year-old Jindo dog underwent enterectomy and enteroanastomosis due to ileus of the intestine at a local veterinary hospital. Grossly, the excised intestine showed markedly thickened multinodular masses in the serosal layer of the upper part, and soft-to-firm, creamcolored neoplastic masses that displayed extensive nodular mucosal protuberances into the lumen. The neoplastic masses were filled with large round cells that were ovoid in shape and they had pale and/or hyperchromatic nuclei. The neoplastic cells had mainly infiltrated into the mucosal and submucosal layers, and they had diffusely invaded the muscular and serosal layers. Therefore, the diagnosis of canine multiple intestinal malignant lymphomatous polyposis was made based on the gross and histopathological findings. The origin of these tumor cells was determined to be B-cells since they were positive for anti-CD20.

Keyword

B-cells; canine; CD20; multiple intestinal lymphoma; lymphomatous polyposis

MeSH Terms

Animals
Antigens, CD20/metabolism
Dog Diseases/*pathology/surgery
Dogs
Immunohistochemistry/veterinary
Intestinal Neoplasms/pathology/surgery/*veterinary
Intestinal Polyps/*pathology/surgery
Lymphoma, Mantle-Cell/pathology/surgery/*veterinary
Male

Figure

• 

  Fig. 1 Gross and histopathological findings of the intestine. (A) Expanded and hypertrophical lesions could be seen in the intestine before enterctomy. (B) The surgically-excised intestine (30 cm in length) included markedly thick multinodular masses in the serosal layer of the upper part and an irregularly thickened wall. (C) Soft-to-firm, cream-colored neoplastic masses (arrowhread) typically showed extensive multi-nodular mucosal protuberances in the lumen. (D) These neoplastic cells were round and ovoid in shape and they were often pale compared to their hyperchromatic nuclei of various sizes with small nucleoli. H&E stain, ×330. (E) These neoplastic cells were mainly infiltrated into mucosal and submucosa, and they had diffusely invaded the muscular and serosal layers. H&E stain, ×33. (F) Tumor cells were positively stained for the CD20 antibody in the tumorous lesions. Immunostaining for CD20 antibody, ×132.

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