Yonsei Med J.  2000 Feb;41(1):150-154. 10.3349/ymj.2000.41.1.150.

A case of nephrogenic diabetes insipidus caused by obstructive uropathy due to prostate cancer

• Hong EG
• Suh Y
• Chung YS
• Kim HM
• Shin GT
• Chung DY
• Park RW

• KMID: 1060288
• DOI: http://doi.org/10.3349/ymj.2000.41.1.150

Abstract

Nephrogenic diabetes insipidus (DI) secondary to chronic urinary tract obstruction is a rare disease. The exact cause is unknown but it is likely that increased collecting duct pressures cause damage to the tubular epithelium, resulting in insensitivity to the action of arginine-vasopressin (AVP). A 77-year-old man complaining of polyuria and polydipsia was treated with alpha glucosidase inhibitor under the impression of polyuria due to diabetes mellitus. But his symptoms did not improve. Water deprivation and AVP administration study revealed that the patient had nephrogenic DI. Urinary tract obstruction due to an enlarged prostate was suggested as a principal cause of nephrogenic DI. The patient underwent transurethral resection of the prostate and bilateral subcapsular orchiectomy. After surgery, the urine osmolarity was normalized and the patient became symptom-free. We report a case of nephrogenic DI due to obstructive uropathy which was cured by surgery eliminating obstruction.

Keyword

Nephrogenic diabetes insipidus; prostate cancer; obstructive uropathy

MeSH Terms

Adenocarcinoma/ultrasonography
Adenocarcinoma/radionuclide imaging
Adenocarcinoma/pathology
Adenocarcinoma/complications*
Aged
Case Report
Constriction, Pathologic/etiology
Diabetes Insipidus, Nephrogenic/etiology*
Human
Male
Prostatic Neoplasms/ultrasonography
Prostatic Neoplasms/radionuclide imaging
Prostatic Neoplasms/pathology
Prostatic Neoplasms/complications*
Urologic Diseases/etiology*