Yonsei Med J.  2011 Nov;52(6):1025-1027. 10.3349/ymj.2011.52.6.1025.

Fever-Induced QTc Prolongation and Ventricular Fibrillation in a Healthy Young Man

• Lim SM
• Pak HN
• Lee MH
• Kim SS
• Joung B

• KMID: 1058826
• DOI: http://doi.org/10.3349/ymj.2011.52.6.1025

Abstract

Long QT syndrome is associated with lethal tachyarrhythmia that can lead to syncope, seizure, and sudden death. Congenital long QT syndrome is a genetic disorder, characterized by delayed cardiac repolarization and prolongation of the QT interval on the electrocardiogram (ECG). Type 2 congenital long QT is linked to mutations in the human ether a go-go-related gene (HERG). There are environmental triggers of adverse cardiac events such as emotional and acoustic stimuli, but fever can also be a potential trigger of life-threatening arrhythmias in long QT syndrome type 2 patients. Herein, we report a healthy young man who experienced fever-induced polymorphic ventricular tachycardia and QT interval prolongation.

Keyword

Sudden cardiac death; long QT syndrome; fever

MeSH Terms

Adult
Electrocardiography
Fever/*complications
Humans
Long QT Syndrome/*diagnosis/*etiology
Male
Ventricular Fibrillation/*diagnosis/*etiology