Ann Rehabil Med.  2015 Oct;39(5):826-832. 10.5535/arm.2015.39.5.826.

Hypokalemia-Induced Rhabdomyolysis by Primary Aldosteronism Coexistent With Sporadic Inclusion Body Myositis

Affiliations
  • 1Department of Physical Medicine and Rehabilitation, Kyung Hee University School of Medicine, Seoul, Korea.
  • 2Department of Physical Education, Korea National Sport University, Seoul, Korea. lkimg@knsu.ac.kr
  • 3Department of Endocrinology and Metabolism, Kyung Hee University School of Medicine, Seoul, Korea.

Abstract

We describes a patient with hypokalemia-induced rhabdomyolysis due to primary aldosteronism (PA), who suffered from slowly progressive muscle weakness after laparoscopic adrenalectomy, and was later diagnosed with coexisting sporadic inclusion body myositis (sIBM). A 54-year-old Asian male presented with severe muscle weakness of both lower extremities. Laboratory findings showed profound hypokalemia, and extreme elevation of the serum creatine phosphokinase levels, suggestive of hypokalemia-induced rhabdomyolysis. Further evaluation strongly suggested PA by an aldosterone-producing adenoma, which was successfully removed surgically. However, muscle weakness slowly progressed one year after the operation and a muscle biopsy demonstrated findings consistent with sIBM. This case is the first report of hypokalemia-induced rhabdomyolysis by PA coexistent with sIBM, to the best of our knowledge.

Keyword

Rhabdomyolysis; Aldosteronism; Hypokalemia; Inclusion body myositis

MeSH Terms

Adenoma
Adrenalectomy
Asian Continental Ancestry Group
Biopsy
Creatine Kinase
Humans
Hyperaldosteronism*
Hypokalemia
Lower Extremity
Male
Middle Aged
Muscle Weakness
Myositis, Inclusion Body*
Rhabdomyolysis*
Creatine Kinase
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