J Korean Med Sci.  1998 Dec;13(6):685-688. 10.3346/jkms.1998.13.6.685.

Psoriasiform eruption triggered by recombinant granulocyte-macrophage colony stimulating factor (rGM-CSF) and exacerbated by granulocyte colony stimulating factor (rG-CSF) in a patient with breast cancer

• Cho SG
• Park YM
• Moon H
• Kim KM
• Bae SS
• Kim GB
• Cho HS
• Kim CC
• Lee KS

• KMID: 1038454
• DOI: http://doi.org/10.3346/jkms.1998.13.6.685

Abstract

Colony-stimulating factors (CSFs) are commonly used for the treatment of neutropenia following chemotherapy and for the mobilization of peripheral blood stem cells (PBSC). We recently experienced a rare case of a new onset of psoriasiform eruption by GM-CSF (granulocyte-macrophage colony-stimulating factor) which was exacerbated by G-CSF (granulocyte colony-stimulating factor) in a patient with breast cancer. A 36-year-old woman had received neoadjuvant chemotherapy (cyclophosphamide, epirubicin and 5-fluorouracil), modified radical mastectomy and adjuvant chemotherapy with paclitaxel and mitoxantrone followed by GM-CSF administration for the treatment of locally advanced breast cancer. She had developed a psoriatic skin lesion on face and both upper arms during leukocyte recovery in spite of no previous history of psoriasis. Next, the chemotherapy course was complicated by a flare of mild psoriatic skin lesion, although CSF was changed into G-CSF due to GM-CSF-associated psoriasis. Subsequently, she had had high-dose chemotherapy and autologous peripheral blood stem cell transplantation for consolidation therapy. GM-CSF was administered for the mobilization of PBSC and post-transplant period, but psoriatic skin lesion did not appear. During 6 months after PBSCT, psoriasiform eruption did not appear.

MeSH Terms

Adult
Breast Neoplasms/drug therapy*
Breast Neoplasms/complications
Carcinoma, Infiltrating Duct/drug therapy
Carcinoma, Infiltrating Duct/complications
Case Report
Female
Granulocyte Colony Stimulating Factor, Recombinant/adverse effects*
Granulocyte Macrophage Colony-Stimulating Factors, Recombinant/adverse effects*
Human
Neutropenia/drug therapy
Neutropenia/chemically induced
Psoriasis/chemically induced*