Korean J Ophthalmol.  2011 Aug;25(4):231-237. 10.3341/kjo.2011.25.4.231.

Combined Treatment of Photodynamic Therapy and Bevacizumab for Choroidal Neovascularization Secondary to Age-Related Macular Degeneration

• Kim HW
• Kim JL
• Lee MH
• Yoo HG
• Chung IY
• Lee JE

• KMID: 1018409
• DOI: http://doi.org/10.3341/kjo.2011.25.4.231

Abstract

PURPOSE
To evaluate the outcome of a combined photodynamic therapy and intravitreal injection of bevacizumab in choroidal neovascularization secondary to age-related macular degeneration.
METHODS
Photodynamic therapy (PDT) was administered to 28 eyes followed by 3 consecutive bevacizumab injections. Patients were followed-up for more than 12 months. At baseline, 1, 3, 6, and 12 months post PDT, visual acuity (VA) and central macular thickness were measured using optical coherence tomography.
RESULTS
The mean VA was significantly improved from logarithm of the minimal angle of resolution 0.86 at baseline to 0.69 at 1 month (p = 0.011), 0.63 at 3 months (p = 0.003), 0.64 at 6 months (p = 0.004) and 0.60 at 12 months (p < 0.001). Central macular thickness decreased significantly from 328.3 microm at baseline to 230.0 microm at 6 months and 229.9 microm at 1 year (p < 0.001). Reinjection mean number was 0.4 for 6 months and 0.8 for 12 months. By 1 year, retreatment was performed in 10 eyes (36%).
CONCLUSIONS
PDT combined with three consecutive intraviteal bevacizumab injections was effective in improving VA and reducing central macular thickness.

Keyword

Bevacizumab; Choroidal neovascularization; Macular degeneration; Photochemotherapy; Verteporfin

MeSH Terms

Aged
Angiogenesis Inhibitors/*administration & dosage
Antibodies, Monoclonal, Humanized/*administration & dosage
Choroidal Neovascularization/diagnosis/*drug therapy/etiology
Dose-Response Relationship, Drug
Drug Therapy, Combination
Female
Fluorescein Angiography
Follow-Up Studies
Fundus Oculi
Humans
Intravitreal Injections
Macula Lutea/drug effects/*pathology
Macular Degeneration/*complications/diagnosis/drug therapy
Male
Photochemotherapy/*methods
Photosensitizing Agents/administration & dosage
Porphyrins/*administration & dosage
Retrospective Studies
Tomography, Optical Coherence
Treatment Outcome
Visual Acuity