- Historical Review and Future of Cardiac Xenotransplantation
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Koh J, Chee HK, Kim KH, Jeong IS, Kim JS, Lee CH, Seo JW
- KMID: 2543049
- Korean Circ J.
- 2023 Jun;53(6):351-366.
- doi: 10.4070/kcj.2022.0351
Along with the development of immunosuppressive drugs, major advances on xenotransplantation were achieved by understanding the immunobiology of xenograft rejection. Most importantly, three predominant carbohydrate antigens on porcine endothelial cells... -
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- Macrophages in xenotransplantation
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Kim JY
- KMID: 2468157
- Korean J Transplant.
- 2019 Dec;33(4):74-82.
- doi: 10.4285/jkstn.2019.33.4.74
Xenotransplantation refers to organ transplantation across species. Immune rejection of xenografts is stronger and faster than that of allografts because of significant molecular differences between species. Recent studies have revealed... -
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- Intra-articular Xenotransplantation of Adipose-Derived Stromal Cells to Treat Osteoarthritis in a Goat Model
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Ko JY, Lee J, Lee J, Im GI
- KMID: 2371105
- Tissue Eng Regen Med.
- 2017 Feb;14(1):65-71.
- doi: 10.1007/s13770-016-0010-5
Adipose-derived stromal cells (ASCs) have been investigated as a cell source for tissue regeneration. The purpose of this study was first to confirm if medial meniscectomy induces osteoarthritis (OA) in... -
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- Current Status of Solid Organ Xenotransplantation
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Yun IJ
- KMID: 2327965
- J Korean Soc Transplant.
- 2016 Jun;30(2):69-76.
- doi: 10.4285/jkstn.2016.30.2.69
Solid organ xenotransplantation using transgenic pig organs is proposed as an alternative method for allo-transplantation. To accomplish this, immunologic and non-immunologic barriers for xenotransplantation should be overcome, and experiments on... -
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- Implications of Calcineurin/NFAT Inhibitors' Regulation of Dendritic Cells and Innate Immune Cells in Islet Xenotransplantation
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Kim YH, Lee WW, Park CG
- KMID: 2168737
- J Bacteriol Virol.
- 2016 Mar;46(1):1-12.
- doi: 10.4167/jbv.2016.46.1.1
Calcineurin inhibitors, such as cyclosporine and tacrolimus (FK506) are broadly used in organ transplantations as immune suppressants. As the calcineurin/NFAT signaling pathway has been identified as critical pathway in the... -
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- Increase in Anti-Gal IgM Level is Associated With Early Graft Failure in Intraportal Porcine Islet Xenotransplantation
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Kang HJ, Lee H, Park EM, Kim JM, Shin JS, Kim JS, Park CG, Kim SJ
- KMID: 2363264
- Ann Lab Med.
- 2015 Nov;35(6):611-617.
- doi: 10.3343/alm.2015.35.6.611
BACKGROUND: Anti-Gal is a major antibody induced in non-human primates (NHPs) after xenotransplantation. To understand the mechanism of graft rejection, we investigated the association between anti-Gal responses and graft failure... -
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- Evaluation of biocompatibility of alpha-1,3 galactosyltransferase knockout pig bone graft in a rat calvarial defect model
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Kim SE, Choi GH, Shim KM, Choi SH, Lee SM, Kang SS
- KMID: 1709210
- J Biomed Res.
- 2014 Jun;15(2):86-91.
The current study was conducted to evaluate the biocompatibility of alpha-1,3 galactosyltransferase knockout pig bone graft in a rat calvarial defect model. Porcine cancellous bones were harvested from general and... -
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- No expression of porcine endogenous retrovirus after pig to monkey xenotransplantation
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Hwang S, Jung YD, Cho K, Ock SA, Oh KB, Kim HS, Yun IJ, Ahn C, Park JK, Im S
- KMID: 1707449
- Lab Anim Res.
- 2014 Jun;30(2):90-93.
- doi: 10.5625/lar.2014.30.2.90
This study was performed to investigate the expression of two porcine endogenous retrovirus (PERV) elements, PERV gag and full-length conserved PERV, in blood cells collected periodically from organ-recipient monkeys that... -
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- Analysis of env Subtypes of Porcine Endogenous Retrovirus in SNU Miniature Pigs
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Sa M, Park CG, Hwang ES
- KMID: 2135360
- J Bacteriol Virol.
- 2014 Mar;44(1):75-83.
- doi: 10.4167/jbv.2014.44.1.75
All xenografts from pigs impose infection risk by porcine endogenous retrovirus (PERV). The purpose of this study was to investigate the env constructs with the comparison of the ratio of... -
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- Application of the Multiplex Cytokine Analysis to Monitor Xenogeneic Immune Responses to the Porcine Islet Graft in Non-Human Primate
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Kim YH, Kim JS, Yoon IH, Shin JS, Kim JM, Kim SJ, Park CG
- KMID: 1779412
- J Korean Med Sci.
- 2013 Dec;28(12):1729-1733.
- doi: 10.3346/jkms.2013.28.12.1729
Non-human primate studies must be conducted prior to the clinical trial of xenotransplantation. In order to develop clinically applicable immune-modulatory regimen through non-human primate studies, close monitoring of xenogeneic immune... -
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- Proteomic analysis of liver in miniature pigs according to developmental stages using two-dimensional electrophoresis and matrix-assisted laser desorption/ionization-time of flight mass spectrometry
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Yi SS, Oh SJ, Kim IY, Yeom HJ, Yeom SC, Hwang SY, Seong JK
- KMID: 2312109
- Lab Anim Res.
- 2013 Sep;29(3):162-167.
Due to the shortage of human organ donors for transplant, various studies of xenotransplantation, or the use of animal organs instead of human organs, have been carried out. The organs... -
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- Multidetector computed tomographic angiography evaluation of micropig major systemic vessels for xenotransplantation
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Ryu JM, Yoon W, Park JH, Yun SP, Jang MW, Han HJ
- KMID: 1067391
- J Vet Sci.
- 2011 Sep;12(3):209-214.
- doi: 10.4142/jvs.2011.12.3.209
Due primarily to the increasing shortage of allogeneic donor organs, xenotransplantation has become the focus of a growing field of research. Currently, micropigs are the most suitable donor animal for... -
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- Evaluation of Porcine Pancreatic Islets Transplanted in the Kidney Capsules of Diabetic Mice Using a Clinically Approved Superparamagnetic Iron Oxide (SPIO) and a 1.5T MR Scanner
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Kim HS, Kim H, Park KS, Moon WK
- KMID: 1119231
- Korean J Radiol.
- 2010 Dec;11(6):673-682.
- doi: 10.3348/kjr.2010.11.6.673
OBJECTIVE: To evaluate transplanted porcine pancreatic islets in the kidney capsules of diabetic mice using a clinically approved superparamagnetic iron oxide (SPIO) and a 1.5T MR scanner. MATERIALS AND METHODS:... -
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- No Evidence of the Productive Replication of Porcine Endogenous Retrovirus (PERV) from SNU Miniature Pigs in Human Cell Line
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Kim JH, Jung ES, Park CG, Kim SJ, Hwang ES
- KMID: 2170306
- Infect Chemother.
- 2010 Jun;42(3):175-180.
- doi: 10.3947/ic.2010.42.3.175
BACKGROUND: The presence of porcine endogenous retrovirus (PERV) has been considered as one of the main hurdles to transplant pig's organs or tissues to human beings. There has been no... -
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- Current Strategies for Successful Islet Xenotransplantation
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Kim H, Yang J, Ahn C
- KMID: 1819843
- J Korean Soc Transplant.
- 2009 Dec;23(3):214-226.
- doi: 10.4285/jkstn.2009.23.3.214
Diabetes mellitus is increasing all over the world and is a serious health problem. Pancreatic islet transplantation is promising treatment for diabetes mellitus, but an imbalance between deceased pancreas donors... -
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- Current Status and Future Perspectives of Xenotransplantation
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Park CG, Kim JS, Shin JS, Kim YH, Kim SJ
- KMID: 1819842
- J Korean Soc Transplant.
- 2009 Dec;23(3):203-213.
- doi: 10.4285/jkstn.2009.23.3.203
Xenotransplantation using pigs as the transplant source holds great promise to resolve the severe shortage of human organ donors. Although stem-cell-derived organ and tissue regeneration have a potential to solve... -
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- Construction of the Porcine Endogenous Retrovirus Envelope Glycoprotein A and B Specific Antibody
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Lee JE, Kim GW, Kim YB, Park HY
- KMID: 1474174
- J Bacteriol Virol.
- 2009 Jun;39(2):137-143.
- doi: 10.4167/jbv.2009.39.2.137
Xenotransplantation using porcine organs could potentially associate with the risk of pathogenic infections, because human tropic porcine endogenous retrovirus (PERV) particles could be released from pig cells or organs. While... -
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- Imaging evaluation of the liver using multi-detector row computed tomography in micropigs as potential living liver donors
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Ryu JM, Kim DH, Lee MY, Lee SH, Park JH, Yun SP, Jang MW, Kim SH, Rho GJ, Han HJ
- KMID: 1102964
- J Vet Sci.
- 2009 Jun;10(2):93-98.
- doi: 10.4142/jvs.2009.10.2.93
The shortage of organ donors has stimulated interest in the possibility of using animal organs for transplantation into humans. In addition, pigs are now considered to be the most likely... -
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- Characterization of Clones of Human Cell Line Infected with Porcine Endogenous Retrovirus (PERV) from Porcine Cell Line, PK-15
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Kim JH, Choi EY, Jung ES, Kwon Y, Lee DS, Hwang DY, Hwang ES
- KMID: 2170243
- Infect Chemother.
- 2009 Feb;41(1):1-8.
- doi: 10.3947/ic.2009.41.1.1
BACKGROUND: Porcine endogenous retroviruses (PERVs) form part of the chromosomes of all pigs. Since they can be produced as infectious virion and infect human cells, safety issues on PERVs infection... -
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- Current Status and Future Perspectives of Xenotransplantation and Stem Cell Research in Transplantation Field
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Park CG, Kim JS, Kim YH
- KMID: 2185933
- J Korean Med Assoc.
- 2008 Aug;51(8):732-744.
- doi: 10.5124/jkma.2008.51.8.732
The severe shortage of human organ donors is one of the biggest problems with organ transplantation. The solution for this problem would be development of artificial organs or mechanical devices,... -
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