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Paeonol accelerates skin wound healing by regulating macrophage polarization and inflammation in diabetic rats

Zhang Z, Chen T, Liu W, Xiong J, Jiang L, Liu M

Diabetic ulcer is usually seen in people with uncontrolled blood sugar. Reportedly, many factors such as impaired glucose metabolism, and macrovascular and microvascular diseases caused angiogenesis disorders and delayed the healing...
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Knockdown of CPEB1 and CPEB4 Inhibits Scar Formation via Modulation of TAK1 and SMAD Signaling

Cui HS, Lee YR, Ro YM, Joo SY, Cho YS, Kim JB, Kim DH, Seo CH

Background: Cytoplasmic polyadenylation element binding (CPEB) proteins are sequencespecific RNA-binding proteins that control translation via cytoplasmic polyadenylation. We previously reported that CPEB1 or CPEB4 knockdown suppresses TAK1 and SMAD signaling...
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Effect of Janus Kinase 3 Inhibitor on Sebaceous Gland Regeneration during Skin Wound Healing

Jo WT, Kim AY, Woo HG, Song HJ, Baik EJ

Background: Janus kinase (Jak) 3 has recently been shown as a beneficial target for the treatment of chronic inflammatory diseases, such as psoriasis and alopecia areata. The role of Jak3...
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Exosomal microRNAs from Mesenchymal Stem Cells: Novel Therapeutic Effect in Wound Healing

Ju C, Liu D

BACKGROUND: Wound healing is a complicated biological process that leads to the regeneration of damaged skin tissue. Determining the methods to promote wound healing has become a hot topic in...
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Neuropeptide Y Promotes the Treatment of Adipose Stem Cells on Type 2 Diabetic Wounds

Lu T, Cong L, Jiang T, Dong X, Song L

BACKGROUND: Type 2 diabetes (T2D) is a common metabolic disorder. Due to insufficient insulin secretion or insulin resistance, increased blood glucose often leads to impaired wound healing in T2D patients....
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Enhanced Bone Formation by Rapidly Formed Bony Wall over the Bone Defect Using Dual Growth Factors

Park J, Jung N, Lee DJ, Oh S, Kim S, Cho SW, Kim JE, Moon HS, Park YB

BACKGROUND: In guided bone regeneration (GBR), there are various problems that occur in the bone defect after the wound healing period. This study aimed to investigate the enhancement of the...
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Efficacy of a long-pulsed 1064-nm Nd:YAG laser in acute scar redness

Choi Y, Ji JM, Sung KP, Kim CH

Background The initial redness of the scar on a postoperative suture site is a natural phenomenon that fades over time. However, with a long period of redness, patients complain about...
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Undiagnosed Behçet Syndrome Presenting with Abdominal Wall Ulceration: A Case Report

Choi HB, Lee CY, Song WJ

Behçet syndrome (BS) is a chronic inflammatory disease that damages blood vessels and affects multiple systems, including the skin, mucosa, joints, eyes, nervous system, and gastrointestinal tract. The disease follows...
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Necessity of Tissue Culture from Clinically Uninfected Wounds in Diabetic Patients

Yun YK, Han SK, Namgoong S, Moon KC, Jeong SH, Dhong ES

Background: The Infectious Diseases Society of America Clinical Practice Guidelines recommends not culturing specimens from patients with diabetes who do not show clinical signs or symptoms of local inflammation. However,...
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A Comparative Study of Dichloromethane and Ethyl Acetate Root Extracts of Celosia trigyna: Phytochemical and Wound Healing Effect Analyses

Ofusori AE, Raharjo Y, Ofusori DA, Adekunle VO

Background: Celosia species have been validated to possess antimicrobial, anti-inflammatory, and antioxidant potential. This study was thus designed to comparatively determine the effect of dichloromethane and ethyl acetate root extracts...
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Relationship between Ischemia–Modified Albumin and the Healing Period of Amputation Wounds in Patients with Diabetes Mellitus Following Non-traumatic Below-Knee Amputation

Heo SY, Lee MJ, Kim Hj, Byun SB

Purpose: The present study examined the effectiveness of the preoperative ischemia-modified albumin (IMA) levels in predicting the healing period of amputation wounds in patients with diabetes mellitus following a non-traumatic...
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Comparison of Corneal Epithelial Wound Healing between Topical RCI001, Solcoseryl, and Polydeoxyribonucleotide in the Murine Ocular Alkali Burn Model

Song MS, Ku YA, Kim S, Chung MH, Kim YH, Kim DH

Purpose: To compare the corneal epithelial wound healing effects of RCI001, Solcoseryl, and polydeoxyribonucleotide (PDRN) in a rat alkali burn model. Methods: In 40 male Sprague-Dawley rats, we induced alkali burn...
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Hyperglycemia-Suppressed SMARCA5 Disrupts Transcriptional Homeostasis to Facilitate Endothelial Dysfunction in Diabetes

Wang J, Zhou H, Shao J, Zhang S, Jin J

Background: Dysfunction of vascular endothelial cells (ECs) plays a central role in the pathogenesis of cardiovascular complications in diabetes. SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 (SMARCA5)...
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Topical Application of Purified Amniotic Fluid Accelerated Healing of Full-Thickness Burns, Negating the Need for Skin Grafts: A Case Report

Kweh MF, Parks M, Salerno A, Vaughn NE, White IA

Full-thickness burns almost always require skin grafting because the severity prevents the natural regenerative process. Here, we illustrate the potential to promote natural skin regeneration utilizing growth factors and regenerative...
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Treatment of Partial-Thickness Burn Wounds with Combined Advanced Therapies: Cultured Allogenic Keratinocyte and Epidermal Growth Factor

Lee KD, Cha EC, Lee J, Kang SY, Burm JS, Cho J

Background: Cultured allogenic keratinocyte (CAK) and epidermal growth factor (EGF) are commonly used biological treatments for partial-thickness burn wounds. A comparative study was conducted on whether the combination therapy of...
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Extracorporeal Shock Wave Therapy and a New Assessment Tool for Intractable Wounds of the Limbs

Sugiyama T, Murakami H, Noguchi K, Kawano K, Shibata M, Shiba N

Background: Extracorporeal shock wave therapy (ESWT) is indicated for intractable skin wounds and skin ulcers; however, assessing its efficacy for wounds at the periphery of the extremities may be difficult...
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A Prospective, Randomized, Non-inferiority Trial to Compare the Efficacy of 3% Povidone-Iodine Foam Dressing and Silver Foam Dressing in the Treatment of Pressure Injuries

Park KH, Baek K, Kim M, Ju MJ, Jung WH, Yoon YS

Background: As chronic wounds such as pressure injuries (PIs) are frequently colonized and can easily deteriorate into infection, it is important to reduce their bacterial load, for which antimicrobial dressings...
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Antiseptics and Cleansing the Chronic Wound: Best Practice

Kim M

In the management of chronic wounds, the concept of “wound hygiene” has emerged to effectively manage biofilms, an obstacle to wound healing. The core principles of wound hygiene are wound...
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Vessel-Derived Decellularized Extracellular Matrices (VdECM): Novel Bio-Engineered Materials for the Wound Healing

Lee CR, Lee YJ, Kwon BY, Lee SJ, Ryu YH, Rhie JW, Moon SH

BACKGROUND: Decellularized extracellular matrix (dECM) is a non-cellular scaffold with various functions in tissue engineering and regenerative medicine. Elastin is related to tissue elasticity and scarless wound healing, abundantly found...
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Role of enkephalin derivative in promoting wound healing and scar remodeling via increased epidermal growth factor in a mouse model

Kim SE, Kim YJ, Cheon YW

Background Enkephalin, an endogenous neuropeptide, binds to the delta (δ) opioid receptor and exerts an antinociceptive effect. Recent studies have suggested that neuropeptides might effectuate cutaneous wound healing. Therefore, we...
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