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A Case of Intrathyroidal Parathyroid Carcinoma Accompanied by Contralateral Parathyroid Hyperplasia

Koo BM, Moon SK, Lee MJ, Kim SW

Parathyroid carcinoma accounts for about 0.5%-5% of all parathyroid neoplasms. Very rarely, but if the intrathyroidal parathyroid gland is present, the carcinoma can arise in that developmental anomaly. It is...
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Association among Body Mass Index, Genetic Variants of FTO, and Thyroid Cancer Risk: A Hospital-Based Case-Control Study of the Cancer Screenee Cohort in Korea

Hoang T, Song D, Lee J, Lee EK, Hwangbo Y, Kim J

Purpose Obesity has been determined to be associated with fat mass and obesity-associated (FTO) gene and thyroid cancer risk. However, the effect of combined interactions between obesity and the FTO gene...
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Clinicopathological Characteristics and Recurrence-Free Survival of Rare Variants of Papillary Thyroid Carcinomas in Korea: A Retrospective Study

Kim M, Cho SW, Park YJ, Ahn HY, Kim HS, Suh YJ, Choi D, Kim BK, Yang GE, Park IS, Yi KH, Jung CK, Kim BH

Background: We aimed to evaluate the clinicopathological features and biological behaviors of Korean thyroid cancer patients with rare variants of papillary thyroid carcinoma (PTC) to address the ambiguity regarding the...
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Effect of Cigarette Smoking on Thyroid Cancer: Meta-Analysis

Lee JH, Chai YJ, Yi KH

Background: Although smoking is generally carcinogenic, its effect on thyroid cancers is still subject to controversy. The purpose of this study was to summarize the role of smoking in relation...
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A Multicenter, Randomized, Controlled Trial for Assessing the Usefulness of Suppressing Thyroid Stimulating Hormone Target Levels after Thyroid Lobectomy in Low to Intermediate Risk Thyroid Cancer Patients (MASTER): A Study Protocol

Lee EK, Kang YE, Park YJ, Koo BS, Chung KW, Ku EJ, Won HR, Yoo WS, Jeon E, Paek SH, Lee YS, Lim DM, Suh YJ, Park HK, Kim HJ, Kim BH, Kim M, Kim SW, Yi KH, Park SK, Jung EJ, Choi JY, Bae JS, Hong JH, Nam KH, Lee YK, Yu HW, Go S, Kang YM, MASTER study group

Background: Postoperative thyroid stimulating hormone (TSH) suppression therapy is recommended for patients with intermediate- and high-risk differentiated thyroid cancer to prevent the recurrence of thyroid cancer. With the recent increase...
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Clinical Outcome of Fine Needle Aspiration Cytology and Washout Thyroglobulin in Suspicious Lymph Nodes in Differentiated Thyroid Carcinoma: Discordant Results in Real-World Practice

Lee J, Park HL, Jo K, Kim MH, Bae JS, Lee S, Jung CK, Jung SL, Lim DJ

Background and Objectives: Fine needle aspiration cytology (FNAC) combined with washout thyroglobulin (Tg) measurement is the gold standard for the evaluation of metastatic lymph nodes (LNs) in thyroid cancer. However,...
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Active Surveillance of Papillary Thyroid Cancer: Past, Present, and Future

Kim JK, Kwon H, Lim W, Moon BI, Paik NS

Active surveillance (AS) of papillary thyroid microcarcinoma was first suggested by Dr. Akira Miyauchi at Kuma Hospital in 1993. Based on several subsequent evidences, AS was approved by the American...
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Influence of Sleep Quality, Coffee Consumption, and Perceived Stress on the Incidence of Thyroid Cancer in Healthy Korean Adults

Kim M, Hwang SY

Purpose: This study aimed to examine the influence of lifestyle-related factors, such as sleep quality, eating habits, and perceived stress, on the incidence of thyroid cancer in healthy adults. Methods: This...
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Assessing the diagnostic performance of thyroid biopsy with recommendations for appropriate interpretation

Ha SM, Baek JH, Na DG, Jung CK, Suh CH, Shong YK, Sung TY, Song DE, Lee JH

Purpose: The diagnostic performance of thyroid biopsy is influenced by several factors, including differences in the Bethesda categorization for malignancy, the inclusion or exclusion of non-diagnostic results, the definition used...
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Anti-proliferative and apoptotic effects of hull-less pumpkin extract on human papillary thyroid carcinoma cell line

Bahadori MH, Azari Z, Zaminy A, Dabirian S, Mehrdad SM, Kondori BJ

Papillary thyroid carcinoma (PTC) is one of the most common cancers of the endocrine system. Previous studies have shown that the extract of hull-less pumpkin seed (HLPS) has a significant...
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Selective inhibition of V600E-mutant BRAF gene induces apoptosis in thyroid carcinoma cell lines

Park KS, Saindane M, Yang EY, Jin T, Rallabandi HR, Heil A, Nam SE, Yoo YB, Yang JH, Kim JB, Park SY, Park WS, Youn YK

Purpose: Papillary thyroid cancer (PTC) has a high incidence of BRAF V600E mutation. The purpose of this study was to evaluate the potential relationship between thyroiditis and BRAF ...
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Molecular Correlates and Nuclear Features of Encapsulated Follicular-Patterned Thyroid Neoplasms

Jung CK, Bychkov A, Song DE, Kim JH, Zhu Y, Liu Z, Keelawat S, Lai CR, Hirokawa M, Kameyama K, Kakudo K

Background: Assessing nuclear features is diagnostically challenging in the aspect of thyroid pathology. The aim of this study was to determine whether pathologists could distinguish BRAF-like and RAS-like nuclear features...
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Best Achievements in Clinical Thyroidology in 2020

Lee EK, Park YJ

This review highlights the most interesting research in thyroidology conducted in 2020. The publications of interest discussed below dealt with the following topics: thyroid dysfunction, risk of thyroid cancer, molecular...
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Initial Experience With Robotic Modified Radical Neck Dissection Using the da Vinci Xi System Through the Bilateral Axillo-Breast Approach

Choi YS, Hong YT, Yi JW

Objectives. The bilateral axillo-breast approach (BABA) to robotic thyroidectomy has been extended to modified radical neck dissection (MRND). This study assessed outcomes in patients who underwent robotic MRND through BABA...
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Malignancy risk of thyroid nodules with nonshadowing echogenic foci

Sohn YM, Na DG, Paik W, Gwon HY, Noh BJ

Purpose: This study was conducted to determine the malignancy risk and diagnostic value of various types of nonshadowing echogenic foci (NEF) in the risk stratification of thyroid nodules. Methods: A total...
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Factors Associated with Health Behaviors in Thyroid Cancer Survivors

Yoon J, Park B

In this study, we compared health behaviors, including current smoking, drinking, and physical inactivity, in thyroid cancer survivors and non-cancer controls and investigated the factors associated with unhealthy behaviors among...
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Lipid Profile Change after Thyroidectomy

Chu CH, Kim SY, Lee YS, Chang HS

Purpose: Thyroid diseases and lipid metabolic abnormalities have been reported to be correlated. In patients with thyroid cancer, thyroid stimulating hormone levels are suppressed to prevent recurrence. Many studies have...
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Clinical Implication of World Health Organization Classification in Patients with Follicular Thyroid Carcinoma in South Korea: A Multicenter Cohort Study

Jin M, Kim ES, Kim BH, Kim HK, Yi HS, Jeon MJ, Kim TY, Kang HC, Kim WB, Shong YK, Kim M, Kim WG

Background: The study aimed to compare the prognostic value of the 4th edition of World Health Organization classification (WHO-2017) with the previous WHO classification (WHO-2004) for follicular thyroid carcinoma (FTC). Methods:...
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Clinical Outcomes of N1b Papillary Thyroid Cancer Patients Treated with Two Different Doses of Radioiodine Ablation Therapy

Jin M, Ahn J, Lee YM, Sung TY, Kim WG, Kim TY, Ryu JS, Kim WB, Shong YK, Jeon MJ

Background: The optimal dose of radioactive iodine (RAI) therapy for N1b papillary thyroid carcinoma (PTC) is controversial. We evaluated the clinical outcome of N1b PTC patients treated with either 100...
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Vandetanib for the Management of Advanced Medullary Thyroid Cancer: A Real-World Multicenter Experience

Kim M, Yoon JH, Ahn J, Jeon MJ, Kim HK, Lim DJ, Kang HC, Kim IJ, Shong YK, Kim TY, Kim BH

Background: Vandetanib is the most widely used tyrosine kinase inhibitor for the treatment of patients with advanced medullary thyroid cancer (MTC). However, only limited data regarding its use outside clinical...
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