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Bee venom reduces burn-induced pain via the suppression of peripheral and central substance P expression in mice

Kang DW, Choi JG, Kim J, Park JB, Lee JH, Kim HW

Background: Scalding burn injuries can occur in everyday life but occur more frequently in young children. Therefore, it is important to develop more effective burn treatments. Objectives: This study examined the...
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Effects of endodontic treatment on salivary levels of CGRP and substance P: a pilot study

Arslan H, Yıldız ED, Köseoğlu S

Objectives: The aim of this study was to evaluate the effects of endodontic treatment on levels of substance P (SP) and calcitonin gene-related peptide (CGRP) in the saliva of patients...
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Ultrastructure of Substance P Immunopositive Axons in the Human Dental Pulp

Moon BH, Ha JH, Han HM, Kim TH, Park SK, Bae YC

There exists very little information on the ultrastructure of substance P immunopositive (+) fibers in the human dental pulp, which may help in understanding the mechanism for substance P associated...
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Fabrication of Microchannels and Evaluation of Guided Vascularization in Biomimetic Hydrogels

Lee J, Lee SH, Lee BK, Park SH, Cho YS, Park Y

BACKGROUND: The fabrication of microchannels in hydrogel can facilitate the perfusion of nutrients and oxygen, which leads to guidance cues for vasculogenesis. Microchannel patterning in biomimetic hydrogels is a challenging...
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Allopregnanolone suppresses mechanical allodynia and internalization of neurokinin-1 receptors at the spinal dorsal horn in a rat postoperative pain model

Fujita M, Fukuda T, Sato Y, Takasusuki T, Tanaka M

BACKGROUND: To identify a new strategy for postoperative pain management, we investigated the analgesic effects of allopregnanolone (Allo) in an incisional pain model, and also assessed its effects on the...
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Substance P and Calcitonin Gene-Related Peptide in the Glands of External Auditory Canal Skin

Yoon YJ, Yoon J, Lee EJ, Kim JS

OBJECTIVES: The earwax (cerumen) that covers external auditory canal (EAC) skin contains a mixture of ceruminous and sebaceous gland substances, such as lipids, peptides, and proteins. The components secreted from...
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Intravenous Administration of Substance P Attenuates Mechanical Allodynia Following Nerve Injury by Regulating Neuropathic Pain-Related Factors

Chung E, Yoon TG, Kim S, Kang M, Kim HJ, Son Y

This study aimed to investigate the analgesic effect of substance P (SP) in an animal model of neuropathic pain. An experimental model of neuropathic pain, the chronic constriction injury (CCI)...
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Substance P and Thiorphan Synergically Enhance Angiogenesis in Wound Healing

Um J, Yu J, Dubon MJ, Park KS

Impaired angiogenesis is a common pathological characteristic of chronic wounds. Therefore, the regulation of angiogenesis is important for proper tissue repair. It was reported that substance P (SP) accelerates wound...
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Olopatadine ophthalmic solution suppresses substance P release in the conjunctivitis models

Tamura T

BACKGROUND: Olopatadine hydrochloride ophthalmic solutions are treated for allergic conjunctival diseases that are a selective histamine H1 receptor antagonist and an inhibitor of the release of mediators including histamine from...
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Silk Fibroin and Substance P Combination Graft for the Reconstruction of a Bone Defect

Park KY, Choi KH, Park YJ, Song JY, Kim SG, Jo YY, Kweon HY, Kang SW

  • KMID: 2009670
  • J Korean Assoc Maxillofac Plast Reconstr Surg.
  • 2011 Jul;33(4):293-300.
PURPOSE: Substance P is a well known neurotransmitter and has been known to mediate pain. Recently, it has been unveiled that substance P is involved in the recruitment of mesenchymal...
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The effect of tumor necrosis factor (TNF)-alpha to induce matrix metalloproteinase (MMPs) from the human dental pulp, gingival, and periodontal ligament cells

Rhim EM, Park SH, Kim DS, Kim SY, Choi KK, Choi GW

OBJECTIVES: In the present study, three kinds of tissues cells (pulp, gingiva, and periodontal ligament) were investigated if those cells express MMP and TIMP when they were stimulated with neuropeptides...
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Viewpoints on Acid-Induced Inflammatory Mediators in Esophageal Mucosa

Harnett KM, Rieder F, Behar J, Biancani P

  • KMID: 2204233
  • J Neurogastroenterol Motil.
  • 2010 Oct;16(4):374-388.
We have focused on understanding the onset of gastroesophageal reflux disease by examining the mucosal response to the presence of acid in the esophageal lumen. Upon exposure to HCl, inflammation...
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Neurokinin and Its Receptors: Association with Learning and Memory

Kim MD, Lee CI

  • KMID: 2287030
  • Korean J Psychopharmacol.
  • 2007 Sep;18(5):280-287.
The neurokinin Substance P is widely distributed in the central nervous system and has been extensively studied in various functional aspects. Substance P has been reported to have memory-promoting, reinforcing,...
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Nerve Ingrowth into Intervertebral Disc in Internal Disc Disruption

Shin JH, Seo JY, Ha KY

  • KMID: 2322934
  • J Korean Soc Spine Surg.
  • 2006 Dec;13(4):275-283.
STUDY DESIGN: The ingrowth of the nociceptive nerve ending into intervertebral disc was examined using immunohistochemistry and quantified using western blotting. OBJECTIVES: To determine if the nociceptive nerve innervates into the...
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Detection of Substance P, Calcitonin Gene-Related Peptide and Prostaglandin E2 in Human Epidural Space

Paek SH, Kim HT, Kim BI

BACKGROUND: Several biochemical mediators, such as substance P, calcitonin gene-related peptide (CGRP) and prostaglandin E2, have been demonstrated to be involved in herniated or degenerated disc-induced radiculopathy. The authors...
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Immunohistochemical localization of calcium binding proteins and some neurotransmitters in myenteric plexus of goat stomach

Lee HS, Nam YS

To understand the neurochemical properties of the gastric myenteric plexus of ruminants, the expression patterns of calbindin D-28k (CB), calretinin (CR), substance P (SP) and calcitonin gene-related peptide (CGRP) were...
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Hypoxia-A Possibility in Fibromyalgia Syndrome Pathogenesis

Kim SH, Moon IS

  • KMID: 2202233
  • J Korean Rheum Assoc.
  • 2006 Sep;13(3):218-225.
OBJECTIVE: We studied the expression of pain-related molecules such as substance P involved in chronic pain of fibromyalgia syndrome (FMS) patients using rat cortical cells in hypoxia. METHODS: We sacrificed pregnant...
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A study of neuropeptides related to headaches in children with meningeal irritation signs

Seo BG, Yoo MH, Shim JW, Shim JY, Jung HL, Park MS, Kim DS

PURPOSE: The headache, one of the symptoms of meningitis, is related to abrupt elevation of intracranial pressure(ICP) or stimulation of intracranial nociceptive structure. However, in cases of mild elevation of...
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The effect of neuropeptides on secretion of Interleukin-8 (IL-8)

Kim KJ, Park SH, Choi KK, Park SJ

We investigated the secretion of Interleukin-8 (IL-8) from ginviva and periodontal ligament stimulated with Substance P (SP) and Calcitonin Gene-related Peptide (CGRP). Gingiva (GF), periodontal ligament (PDLF) and pulp (PF)...
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Expression of Substance P in the Experimental Diabetic Rat Retina

Lee SM, Park SJ, Kang TH, Chung JW, Chun MH, Oh SJ

  • KMID: 1937827
  • Korean J Anat.
  • 2006 Apr;39(2):159-167.
Substance P (Sub P) being composed of 11 amino acids sequence is a kind of tachykinin family peptides. It has been known that this substance plays a role of neurotransmitter...
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