- Advancements in the Management of Moderate-to-Severe Ulcerative Colitis: A Revised 2023 Korean Treatment Guidelines
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Na SY
- KMID: 2546480
- Korean J Med.
- 2023 Oct;98(5):223-230.
- doi: 10.3904/kjm.2023.98.5.223
Biologics such as anti-tumor necrosis factor agents have been the cornerstone for the treatment of inflammatory bowel disease but face limitations, including loss of response and risk of opportunistic infections... -
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- Management of inflammatory bowel disease beyond tumor necrosis factor inhibitors: novel biologics and small-molecule drugs
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Na SY, Kim YS
- KMID: 2533133
- Korean J Intern Med.
- 2022 Sep;37(5):906-919.
- doi: 10.3904/kjim.2022.152
The incidence and prevalence of inflammatory bowel disease (IBD), comprising Crohn’s disease and ulcerative colitis, have increased in Asia and developing countries. In the past two decades, anti-tumor necrosis factor... -
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- Predicting human pharmacokinetics from preclinical data: clearance
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Yim DS, Bae SH, Choi S
- KMID: 2525610
- Transl Clin Pharmacol.
- 2021 Jun;29(2):78-87.
- doi: 10.12793/tcp.2021.29.e12
We have streamlined known in vitro methods used to predict the clearance (CL) of small molecules in humans in this tutorial. There have been many publications on in vitro methods... -
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- Therapeutic New Era for Atopic Dermatitis: Part 2. Small Molecules
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Ahn J, Choi Y, Simpson EL
- KMID: 2513590
- Ann Dermatol.
- 2021 Apr;33(2):101-107.
- doi: 10.5021/ad.2021.33.2.101
Atopic dermatitis (AD) is a chronic, inflammatory cutaneous disease driven by immune dysregulation and skin barrier dysfunction. Currently, we are experiencing a new era of understanding of the pathogenesis of... -
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- Generation of Hepatic Progenitor Cells from the Primary Hepatocytes of Nonhuman Primates Using Small Molecules
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Hong DH, Lee C, Kim Y, Bum S, Han SC, Kim SJ, Yang HM, Choi D, Jeong J, Ryu K
- KMID: 2514875
- Tissue Eng Regen Med.
- 2021 Apr;18(2):305-313.
- doi: 10.1007/s13770-020-00327-8
BACKGROUND: Since primates have more biological similarities to humans than do other animals, they are a valuable resource in various field of research, including biomedicine, regenerative medicine, and drug discovery.... -
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- Mechanism-based Drug Therapy of Inflammatory Bowel Disease With Special Reference to Rheumatic Disease
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Park JJ
- KMID: 2504028
- J Rheum Dis.
- 2020 Jul;27(3):128-135.
- doi: 10.4078/jrd.2020.27.3.128
Inflammatory bowel disease (IBD), comprised of Crohn’s disease and ulcerative colitis, is a chronic, relapsing, and remitting disease of the gastrointestinal tract whose incidence is rising worldwide, especially in East... -
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- Modulation of Immunosuppression by Oligonucleotide-Based Molecules and Small Molecules Targeting Myeloid-Derived Suppressor Cells
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Lim J, Lee A, Lee HG, Lim JS
- KMID: 2507817
- Biomol Ther.
- 2020 Jan;28(1):1-17.
- doi: 10.4062/biomolther.2019.069
Myeloid-derived suppressor cells (MDSCs) are immature myeloid cells that exert suppressive function on the immune response. MDSCs expand in tumor-bearing hosts or in the tumor microenvironment and suppress T cell... -
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- Diverse Effects of Small Molecule Inhibitors on Actin Cytoskeleton Dynamics in HIV-1 Infection
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Shin Y, Choi BS, Kim KC, Kim K, Yoon CH
- KMID: 2452048
- J Bacteriol Virol.
- 2019 Jun;49(2):69-80.
- doi: 10.4167/jbv.2019.49.2.69
The dynamics of the actin cytoskeleton plays a pivotal role in the process of cell division, the transportation of organelles, vesicle trafficking and cell movement. Human immunodeficiency virus type 1... -
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- Afatinib Reduces STAT6 Signaling of Host ARPE-19 Cells Infected with Toxoplasma gondii
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Yang Z, Ahn HJ, Park YH, Nam HW
- KMID: 2374014
- Korean J Parasitol.
- 2016 Feb;54(1):31-38.
- doi: 10.3347/kjp.2016.54.1.31
Specific gene expressions of host cells by spontaneous STAT6 phosphorylation are major strategy for the survival of intracellular Toxoplasma gondii against parasiticidal events through STAT1 phosphorylation by infection provoked IFN-γ.... -
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- Dual Inhibitors Against Topoisomerases and Histone Deacetylases
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Seo YH
- KMID: 2171332
- J Cancer Prev.
- 2015 Jun;20(2):85-91.
- doi: 10.15430/JCP.2015.20.2.85
Topoisomerases and histone deacetylases (HDACs) are considered as important therapeutic targets for a wide range of cancers, due to their association with the initiation, proliferation and survival of cancer cells.... -
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- Small Molecule Inhibitors to Disrupt Protein-protein Interactions of Heat Shock Protein 90 Chaperone Machinery
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Seo YH
- KMID: 2171313
- J Cancer Prev.
- 2015 Mar;20(1):5-11.
- doi: 10.15430/JCP.2015.20.1.5
Heat shock protein 90 (Hsp90) is an adenosine triphosphate dependent molecular chaperone in eukaryotic cells that regulates the activation and maintenance of numerous regulatory and signaling proteins including epidermal growth... -
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- Gefitinib Inhibits the Growth of Toxoplasma gondii in HeLa Cells
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Yang Z, Ahn HJ, Nam HW
- KMID: 1792207
- Korean J Parasitol.
- 2014 Aug;52(4):439-441.
- doi: 10.3347/kjp.2014.52.4.439
Toxoplasma gondii is the causative agent of toxoplasmosis with symptoms of congenital neurological and ocular diseases and acquired lymphadenitis, retinochoroiditis, and meningoencephalitis. Small molecules which block the activity of protein... -
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- AAD-2004 Attenuates Progressive Neuronal Loss in the Brain of Tg-betaCTF99/B6 Mouse Model of Alzheimer Disease
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Baek IS, Kim TK, Seo JS, Lee KW, Lee YA, Cho J, Gwag BJ, Han PL
- KMID: 2165439
- Exp Neurobiol.
- 2013 Mar;22(1):31-37.
- doi: 10.5607/en.2013.22.1.31
Alzheimer's disease (AD) is a neurodegenerative disease that proceeds with the age-dependent neuronal loss, an irreversible event which causes severe cognitive and psychiatric devastations. In the present study, we investigated... -
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- Small Molecule Inhibitors in Rheumatoid Arthritis
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Lee EB
- KMID: 2223092
- J Rheum Dis.
- 2012 Jun;19(3):118-124.
- doi: 10.4078/jrd.2012.19.3.118
Rheumatoid arthritis (RA) is a chronic systemic inflammatory disease predominantly affecting diarthroidal joints. Following the successful application of biologic agents, several small molecule inhibitors are currently under clinical trials. Small... -
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- Establishment of High Throughput Screening System Using Human Umbilical Cord-derived Mesenchymal Stem Cells
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Park EG, Cho T, Oh K, Kwon SK, Lee DS, Park SB, Cho J
- KMID: 2170772
- Int J Oral Biol.
- 2012 Jun;37(2):43-50.
The use of high throughput screening (HTS) in drug development is principally for the selection new drug candidates or screening of chemical toxicants. This system minimizes the experimental environment and... -
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- Benzoxathiol derivative BOT-4-one suppresses L540 lymphoma cell survival and proliferation via inhibition of JAK3/STAT3 signaling
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Kim BH, Min YS, Choi JS, Baeg GH, Kim Y, Shin JW, Kim TY, Ye SK
- KMID: 1009971
- Exp Mol Med.
- 2011 May;43(5):313-321.
- doi: 10.3858/emm.2011.43.5.035
Persistently activated JAK/STAT3 signaling pathway plays a pivotal role in various human cancers including major carcinomas and hematologic tumors, and is implicated in cancer cell survival and proliferation. Therefore, inhibition... -
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