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Acute and 28-days subacute toxicity studies of Gαq-RGS2 signaling inhibitor

Beladiya JV, Mehta AA

Background: The aim of study was to evaluate the single oral dose and 28 day repeated oral administration toxicity profile of the synthetic compound Gαq-RGS2 signaling inhibitor, (1-(5-chloro-2-hydroxyphenyl)-3-(4-(trifluoromethyl)phenyl)-1 H-1,2,4-triazol-5(4 H)-one)...
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Evaluation of General Toxicity and Genotoxicity of the Silkworm Extract Powder

Heo HS, Choi JH, Oh JJ, Lee WJ, Kim SS, Lee DH, Lee HK, Song SW, Kim KH, Choi YK, Ryu KS, Kang BH

  • KMID: 2317845
  • Toxicol Res.
  • 2013 Dec;29(4):263-278.
The silkworm extract powder contain 1-deoxynojirimycin (DNJ), a potent alpha-glycosidase inhibitor, has therapeutic potency against diabetes mellitus. Therefore, natural products containing DNJ from mulberry leaves and silkworm are consumed as...
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Single Oral Dose Toxicity Study of Prebrewed Armeniacae Semen in Rats

Park JH, Seo BI, Cho SY, Park KR, Choi SH, Han CK, Song CH, Park SJ, Ku SK

  • KMID: 2317821
  • Toxicol Res.
  • 2013 Jun;29(2):91-98.
Armeniacae semen (AS) has been considered a toxic herb in the Korean medicine as it contains hydrogen cyanide and amygdalin, especially in its endocarp. Therefore, prebrewed AS that is devoid...
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Mouse Single Oral Dose Toxicity Test of Bupleuri Radix Aqueous Extracts

Kim KH, Gam CO, Choi SH, Ku SK

  • KMID: 2052546
  • Toxicol Res.
  • 2012 Mar;28(1):11-18.
The aim of this study was to evaluate the single oral dose toxicity of Bupleuri Radix (BR) aqueous extracts, it has been traditionally used as anti-inflammatory agent, in male and...
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Biological Activity and Single Oral Dose Toxicity of Dansam-samultang

Lee IC, Kim BH, Kim MK

In this study, we investigated the in vitro antioxidative effects, antimicrobial activities and single oral dose toxicity of the extracts from Dansam-samultang to evaluate its use as a functional ingredient...
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Investigations of Samwhang-sasimtang Extracts on Biological Activities In Vitro and Vivo

Lee IC, Kim BH, Kim MK

In this study, we investigated the in vitro antioxidative effects, antimicrobial activities and single oral dose toxicity of the extracts from Samwhang-sasimtang to evaluate its use as a functional ingredient...
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