- Adverse effects of farnesyltransferase inhibitors on insulin actions
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Yi SJ, Jhun BH, Kim K
- KMID: 2394597
- J Biomed Transl Res.
- 2017 Sep;18(3):113-117.
- doi: 10.12729/jbtr.2017.18.3.113
Ras activates a series of downstream effectors, including the mitogen-activated protein kinase pathway and the Rac/Rho pathway after insulin stimulation. Mutations in Ras are found in approximately 30% of all... -
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- Study on Association between an H-RAS Gene Polymorphism and Gastric Cancer Development
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Oh JH
- KMID: 1775869
- Korean J Gastroenterol.
- 2010 Aug;56(2):121-122.
- doi: 10.4166/kjg.2010.56.2.121
No abstract available. -
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- G protein signaling in the parasite Entamoeba histolytica
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Bosch DE, Siderovski DP
- KMID: 2154234
- Exp Mol Med.
- 2013 Mar;45(3):e15.
The parasite Entamoeba histolytica causes amebic colitis and systemic amebiasis. Among the known amebic factors contributing to pathogenesis are signaling pathways involving heterotrimeric and Ras superfamily G proteins. Here, we... -
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- N-ras Mutation Detection by Pyrosequencing in Adult Patients with Acute Myeloid Leukemia at a Single Institution
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Jeong JH, Park SH, Park MJ, Kim MJ, Kim KH, Park PW, Seo YH, Lee JH, Park J, Hong J, Ahn JY
- KMID: 1781320
- Ann Lab Med.
- 2013 May;33(3):159-166.
- doi: 10.3343/alm.2013.33.3.159
BACKGROUND: N-ras mutations are one of the most commonly detected abnormalities of myeloid origin. N-ras mutations result in a constitutively active N-ras protein that induces uncontrolled cell proliferation and inhibits... -
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- Study on Mutation of ras Gene in DMBA induced Carcinoma of Hamster Buccal Pouch
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Song SC, Kim KW, Lee JH, Kim CJ
- KMID: 1961256
- J Korean Assoc Oral Maxillofac Surg.
- 2000 Dec;26(6):581-590.
Alterations in the cellular genome affecting the expression or function of genes controlling cell growth and differentiation are considered to be the main cause of cancer. Over 30 oncogenes can... -
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- Akt is involved in the inhibition of cell proliferation by EGF
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Jeon SH, Jeong WJ, Cho JY, Lee KH, Choi KY
- KMID: 756072
- Exp Mol Med.
- 2007 Aug;39(4):491-498.
Axin is a negative regulator of the Wnt/beta-catenin pathway and is involved in the regulation of axis formation and proliferation. Involvement of Axin in the regulation of other signaling pathways... -
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- Epidermal growth factor receptor overexpression and K-ras mutation detection in the oral squamous cell carcinoma
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Moon BC, Han SJ, Jeong D, Kim KW
- KMID: 2328613
- J Korean Assoc Oral Maxillofac Surg.
- 2011 Oct;37(5):396-402.
INTRODUCTION: Epidermal growth factor is a single-chain polypeptide consisting of 53 amino acids with potent mitogenic activity that stimulates the proliferation of a range of normal and neoplastic cells through... -
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- The Relationship between Microvessel Count and the Expression of Vascular Endothelial Growth Factor, p53, and K-ras in Non-Small Cell Lung Cancer
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Kang YH, Kim KS, Yu YK, Lim SC, Kim YC, Park KO
- KMID: 648299
- J Korean Med Sci.
- 2001 Aug;16(4):417-423.
- doi: 10.3346/jkms.2001.16.4.417
Using immunohistochemical staining, we studied the relationship between the microvessel count (MC) and the expression of K-ras, mutant p53 protein, and vascular endothelial growth factor (VEGF) in 61 surgically resected... -
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- Predictive Significance of KRAS and Tau for Chemoresponse in Advanced Non-Small-Cell Lung Cancer
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Yoo J, Shim BY, Yoo CY, Kang SJ, Lee KY
- KMID: 1472622
- Korean J Pathol.
- 2009 Oct;43(5):435-440.
- doi: 10.4132/KoreanJPathol.2009.43.5.435
BACKGROUND: Taxane-platinum combinations are often used as first-line treatments for patients with advanced non-small cell lung cancer (NSCLC). Response to chemotherapy for these patients is still poor. The aim of... -
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- Study on Association between an H-RAS Gene Polymorphism and Gastric Cancer Development
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Song HJ, Pyun JA, Lee KJ, Cho SW, Kwack KB
- KMID: 1775861
- Korean J Gastroenterol.
- 2010 Aug;56(2):78-82.
- doi: 10.4166/kjg.2010.56.2.78
BACKGROUND/AIMS: Oncogenic RAS gene mutations have been frequently observed in many tumor types, and their associations with various cancers were reported. This study was conducted to evaluate the association between... -
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- Concomitance of P-gp/LRP Expression with EGFR Mutations in Exons 19 and 21 in Non-Small Cell Lung Cancers
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Wei H, Lu W, Li M, Zhang Q, Lu S
- KMID: 2466351
- Yonsei Med J.
- 2016 Jan;57(1):50-57.
- doi: 10.3349/ymj.2016.57.1.50
PURPOSE: Traditional chemotherapy is the main adjuvant therapy for the treatment of non-small cell lung cancer (NSCLC). However, the emergence of multi-drug resistance (MDR) has greatly restricted the curative effect... -
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- ANT2 suppression by shRNA restores miR-636 expression, thereby downregulating Ras and inhibiting tumorigenesis of hepatocellular carcinoma
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Jang JY, Lee YS, Jeon YK, Lee K, Jang JJ, Kim CW
- KMID: 2154222
- Exp Mol Med.
- 2013 Jan;45(1):e3.
MicroRNAs (miRNAs) participate in diverse biological functions and carcinogenesis by inhibiting specific gene expression. We previously reported that suppression of adenine nucleotide translocase 2 (ANT2) by using the short hairpin... -
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- Bone morphogenetic protein 4 stimulates neuronal differentiation of neuronal stem cells through the ERK pathway
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Moon BS, Yoon JY, Kim MY, Lee SH, Choi T, Choi KY
- KMID: 1109434
- Exp Mol Med.
- 2009 Feb;41(2):116-125.
- doi: 10.3858/emm.2009.41.2.014
Bone morphogenic protein 4 (BMP4), a member of the TGF-beta superfamily, induced neural differentiation of neural stem cells (NSCs) grown in a medium containing basic fibroblast growth factor (bFGF). The... -
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- Activation of KRAS promotes the mesenchymal features of basal-type breast cancer
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Kim RK, Suh Y, Yoo KC, Cui YH, Kim H, Kim MJ, Kim IG, Lee SJ
- KMID: 2155402
- Exp Mol Med.
- 2015 Jan;47(1):e137.
- doi: 10.1038/emm.2014.99
Basal-type breast cancers are among the most aggressive and deadly breast cancer subtypes, displaying a high metastatic ability associated with mesenchymal features. However, the molecular mechanisms underlying the maintenance of... -
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- Role of Ras/ERK-dependent pathway in the erythroid differentiation of K562 cells
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Kang CD, Do IR, Kim KW, Ahn BK, Kim SH, Chung BS, Jhun BH, Yoo MA
- KMID: 1029935
- Exp Mol Med.
- 1999 Jun;31(2):76-82.
The chronic myelogenous leukemic K562 cell line carrying Bcr-Abl tyrosine kinase is considered as pluripotent hematopoietic progenitor cells expressing markers for erythroid, granulocytic, monocytic, and megakaryocytic lineages. Here we investigated the signaling modulations... -
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- Pathogenesis and Management of Serrated Polyps: Current Status and Future Directions
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Anderson J
- KMID: 2070073
- Gut Liver.
- 2014 Nov;8(6):582-589.
- doi: 10.5009/gnl14248
Hyperplastic or serrated polyps were once believed to have little to no clinical significance. A subset of these polyps are now considered to be precursors to colorectal cancers (CRC) in... -
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- Prognostic Role of KRAS mRNA Expression in Breast Cancer
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Hwang KT, Kim BH, Oh S, Park SY, Jung J, Kim J, Choi IS, Jeon SY, Kim WY
- KMID: 2470892
- J Breast Cancer.
- 2019 Dec;22(4):548-561.
- doi: 10.4048/jbc.2019.22.e55
PURPOSE: We investigated the prognostic role of KRAS mRNA expression in breast cancer using The Cancer Genome Atlas (TCGA) and Molecular Taxonomy of Breast Cancer International Consortium (METABRIC) databases. METHODS: Clinical... -
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- The Impact of Cigarette Smoking on the Frequency of and Qualitative Differences in KRAS Mutations in Korean Patients with Lung Adenocarcinoma
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Kim HR, Ahn JR, Lee JG, Bang DH, Ha SJ, Hong YK, Kim SM, Nam KC, Rha SY, Soo RA, Riely GJ, Kim JH, Cho BC
- KMID: 2158219
- Yonsei Med J.
- 2013 Jul;54(4):865-874.
- doi: 10.3349/ymj.2013.54.4.865
PURPOSE: This study was designed to determine the relationship of cigarette smoking to the frequency and qualitative differences among KRAS mutations in lung adenocarcinomas from Korean patients. MATERIALS AND METHODS: Detailed... -
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- LIN28B confers radio-resistance through the posttranscriptional control of KRAS
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Jeong SH, Wu HG, Park WY
- KMID: 1099867
- Exp Mol Med.
- 2009 Dec;41(12):912-918.
- doi: 10.3858/emm.2009.41.12.097
To screen the differentially expressed microRNAs related to radio-resistance, we compared the microRNA profiles of lung cancer cells with different responses to ionizing radiation (IR). Of 328 microRNAs in microarray,... -
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- Mutational Analysis of KRAS, BRAF, and TP53 Genes of Ovarian Serous Carcinomas in Korean Women
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Cho YH, Kim DY, Kim JH, Kim YM, Kim KR, Nam JH, Kim YT
- KMID: 2396071
- Yonsei Med J.
- 2009 Apr;50(2):266-272.
PURPOSE: To assess the prevalence of KRAS, BRAF, and TP53 mutations in cases of low-grade and high-grade serous carcinomas and to evaluate the clinical outcomes of these morphologically distinct carcinomas.... -
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