- Building and analyzing machine learning-based warfarin dose prediction models using scikit-learn
-
Ahn S
- KMID: 2538879
- Transl Clin Pharmacol.
- 2022 Dec;30(4):172-181.
- doi: 10.12793/tcp.2022.30.e22
For personalized drug dosing, prediction models may be utilized to overcome the inter-individual variability. Multiple linear regression has been used as a conventional method to model the relationship between patient... -
- CITED
-
- Close
- SHARE
-
- Close
- Methodological Round: Prospect of Artificial Intelligence Based on Electronic Medical Record
-
Lee S, Kim HS
- KMID: 2531867
- J Lipid Atheroscler.
- 2021 Sep;10(3):282-290.
- doi: 10.12997/jla.2021.10.3.282
With the advent of the big data era, the interest of the international community is focusing on increasing the utilization of medical big data. Many hospitals are attempting to increase... -
- CITED
-
- Close
- SHARE
-
- Close
- The role of regional analgesia in personalized postoperative pain management
-
Chitnis SS, Tang R, Mariano ER
- KMID: 2506865
- Korean J Anesthesiol.
- 2020 Oct;73(5):363-371.
- doi: 10.4097/kja.20323
Pain management plays a fundamental role in enhanced recovery after surgery pathways. The concept of multimodal analgesia in providing a balanced and effective approach to perioperative pain management is widely... -
- CITED
-
- Close
- SHARE
-
- Close
- Personalized Psychiatry and Depression: The Role of Sociodemographic and Clinical Variables
-
Perna G, Alciati A, Daccò S, Grassi M, Caldirola
- KMID: 2501497
- Psychiatry Investig.
- 2020 Mar;17(3):193-206.
- doi: 10.30773/pi.2019.0289
Despite several pharmacological options, the clinical outcomes of major depressive disorder (MDD) are often unsatisfactory. Personalized psychiatry attempts to tailor therapeutic interventions according to each patient’s unique profile and characteristics.... -
- CITED
-
- Close
- SHARE
-
- Close
- Molecular Imaging in Breast Cancer
-
Miladinova D
- KMID: 2465866
- Nucl Med Mol Imaging.
- 2019 Oct;53(5):313-319.
- doi: 10.1007/s13139-019-00614-w
Breast cancer (BC) is themost common cancer among females withmore than 2 million new cases diagnosed worldwide in 2018. Although the prognosis in the majority of cases in the early... -
- CITED
-
- Close
- SHARE
-
- Close
- Genome Engineering for Osteoarthritis: From Designer Cells to Disease-Modifying Drugs
-
Choi YR, Collins KH, Lee JW, Kang HJ, Guilak F
- KMID: 2455043
- Tissue Eng Regen Med.
- 2019 Aug;16(4):335-343.
- doi: 10.1007/s13770-018-0172-4
BACKGROUND: Osteoarthritis (OA) is a highly prevalent degenerative joint disease involving joint cartilage and its surrounding tissues. OA is the leading cause of pain and disability worldwide. At present, there... -
- CITED
-
- Close
- SHARE
-
- Close
- Neonatal transient pseudohypoparathyroidism: could it be included among inactivating parathyroid hormone (PTH)/PTH-related protein signalling disorders?
-
De Rose DU, Perri A, Gallini F, Priolo F, Tiberi E, Vento G, Zecca E
- KMID: 2452090
- Ann Pediatr Endocrinol Metab.
- 2019 Jun;24(2):129-132.
- doi: 10.6065/apem.2019.24.2.129
We report a case of transient pseudohypoparathyroidism in a full-term newborn that presented at 20 hours of life with hypocalcemic seizures, hyperphosphatemia and raised parathormone levels. The diagnosis of pseudohypoparathyroidism... -
- CITED
-
- Close
- SHARE
-
- Close
- A Therapeutic Strategy for Alzheimer's Disease Focused on Immune-inflammatory Modulation
-
Kim SH, Noh MY, Kim HJ, Oh KW, Park J, Lee S, Moon Y, Kim YE, Bae JS, Jin HK, K-ARPI
- KMID: 2451000
- Dement Neurocogn Disord.
- 2019 Jun;18(2):33-46.
- doi: 10.12779/dnd.2019.18.2.33
Alzheimer's disease (AD), the most common form of dementia, has emerged as a major global public health challenge. However, the complexity of AD in its biological, genetic, and clinical aspects... -
- CITED
-
- Close
- SHARE
-
- Close
- Perspectives in Radiomics for Personalized Medicine and Theranostics
-
Ha S
- KMID: 2450005
- Nucl Med Mol Imaging.
- 2019 Jun;53(3):164-166.
- doi: 10.1007/s13139-019-00578-x
Radiomics handles imaging biomarker from high-throughput feature extraction through complex pattern recognition that is difficult for human to process. Recent medical paradigms are rapidly changing to personalized medicine, including molecular... -
- CITED
-
- Close
- SHARE
-
- Close
- Biologic agents for asthma treatment
-
Kim SR, Lee JH
- KMID: 2434124
- Allergy Asthma Respir Dis.
- 2019 Jan;7(1):3-12.
- doi: 10.4168/aard.2019.7.1.3
Most treatment strategies for asthma currently include inhaled corticosteroids, with the addition of long-acting beta-2-agonists or leukotriene modifiers, if necessary. However, some patients may not respond to conventional treatment. A... -
- CITED
-
- Close
- SHARE
-
- Close
- The Generation and Application of Patient-Derived Xenograft Model for Cancer Research
-
Jung J, Seol HS, Chang S
- KMID: 2403469
- Cancer Res Treat.
- 2018 Jan;50(1):1-10.
- doi: 10.4143/crt.2017.307
Establishing an appropriate preclinical model is crucial for translational cancer research. The most common way that has been adopted by far is grafting cancer cell lines, derived from patients. Although... -
- CITED
-
- Close
- SHARE
-
- Close
- Reference Values for a Panel of Cytokinergic and Regulatory Lymphocyte Subpopulations
-
Sorrenti V, Marenda B, Fortinguerra S, Cecchetto , Quartesan , Zorzi G, Zusso M, Giusti P, Buriani A
- KMID: 2362799
- Immune Netw.
- 2016 Dec;16(6):344-357.
- doi: 10.4110/in.2016.16.6.344
Lymphocyte subpopulations producing cytokines and exerting regulatory functions represent key immune elements. Given their reciprocal interdependency lymphocyte subpopulations are usually assayed as diagnostic panels, rather than single biomarkers for specialist... -
- CITED
-
- Close
- SHARE
-
- Close
- Ultra-rare Disease and Genomics-Driven Precision Medicine
-
Lee S, Choi M
- KMID: 2328164
- Genomics Inform.
- 2016 Jun;14(2):42-45.
- doi: 10.5808/GI.2016.14.2.42
Since next-generation sequencing (NGS) technique was adopted into clinical practices, revolutionary advances in diagnosing rare genetic diseases have been achieved through translating genomic medicine into precision or personalized management. Indeed,... -
- CITED
-
- Close
- SHARE
-
- Close
- Biomarkers of adult asthma and personalized medicine
-
Sim DW, Lee JH
- KMID: 2218613
- Allergy Asthma Respir Dis.
- 2016 Jan;4(1):4-13.
- doi: 10.4168/aard.2016.4.1.4
The concept of personalized medicine for disease diagnosis, treatment, and management, considering individual variability, including susceptibility, clinical manifestations, and drug responsiveness, is a global emerging trend in medicine, which is... -
- CITED
-
- Close
- SHARE
-
- Close
- Cancer Cell Line Panels Empower Genomics-Based Discovery of Precision Cancer Medicine
-
Kim HS, Sung YJ, Paik S
- KMID: 2163608
- Yonsei Med J.
- 2015 Sep;56(5):1186-1198.
- doi: 10.3349/ymj.2015.56.5.1186
Since the first human cancer cell line, HeLa, was established in the early 1950s, there has been a steady increase in the number and tumor type of available cancer cell... -
- CITED
-
- Close
- SHARE
-
- Close
- Preclinical Assessment of the Anticancer Drug Response of Plexiform Neurofibroma Tissue Using Primary Cultures
-
Jiang W, Mautner VF, Friedrich , Kluwe L
- KMID: 2242662
- J Clin Neurol.
- 2015 Apr;11(2):172-177.
- doi: 10.3988/jcn.2015.11.2.172
BACKGROUND AND PURPOSE: Individualized drug testing for tumors using a strategy analogous to antibiotic tests for infectious diseases would be highly desirable for personalized and individualized cancer care. METHODS: Primary cultures... -
- CITED
-
- Close
- SHARE
-
- Close
- Personalized treatment of hepatitis B
-
Lok AS
- KMID: 2155284
- Clin Mol Hepatol.
- 2015 Mar;21(1):1-6.
- doi: 10.3350/cmh.2015.21.1.1
There are seven approved drugs for treatment of hepatitis B. Professional guidelines provide a framework for managing patients but these guidelines should be interpreted in the context of the individual... -
- CITED
-
- Close
- SHARE
-
- Close
- Pharmacometabolomics: Current Applications and Future Perspectives
-
Kim HJ, Yoon YR
- KMID: 2317851
- Transl Clin Pharmacol.
- 2014 Jun;22(1):8-10.
Metabolomics, a novel "omics" platform, is a powerful tool for the discovery of clinically useful biomarkers and biochemical processes to improve diagnosis and therapy. Through the use of advanced analytical... -
- CITED
-
- Close
- SHARE
-
- Close
- Comprehensive Variant Screening of the UGT Gene Family
-
Kim JY, Cheong HS, Park BL, Kim LH, Namgoong S, Kim JO, Kim HD, Kim YH, Chung MW, Han SY, Shin HD
- KMID: 1779911
- Yonsei Med J.
- 2014 Jan;55(1):232-239.
- doi: 10.3349/ymj.2014.55.1.232
PURPOSE: UGT1A1, UGT2B7, and UGT2B15 are well-known pharmacogenes that belong to the uridine diphosphate glucuronyltransferase gene family. For personalized drug treatment, it is important to study differences in the frequency... -
- CITED
-
- Close
- SHARE
-
- Close
- Biomarkers for Stroke
-
Kim SJ, Moon GJ, Bang OY
- KMID: 2223736
- J Stroke.
- 2013 Jan;15(1):27-37.
BACKGROUND: Major stroke clinical trials have failed during the past decades. The failures suggest the presence of heterogeneity among stroke patients. Biomarkers refer to indicators found in the blood, other... -
- CITED
-
- Close
- SHARE
-
- Close
