- Age-dependent changes of p53 and p63 immunoreactivities in the mouse hippocampus
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Lee TK, Park YE, Park CW, Kim B, Lee JC, Park JH, Lee HA, Won MH, Ahn JH
- KMID: 2470010
- Lab Anim Res.
- 2019 Oct;35(3):140-147.
- doi: 10.1186/s42826-019-0022-0
P53 and its family member p63 play important roles in cellular senescence and organismal aging. In this study, p53 and p63 immunoreactivity were examined in the hippocampus of young, adult... -
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- p40 Immunohistochemistry Is an Excellent Marker in Primary Lung Squamous Cell Carcinoma
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Affandi KA, Tizen NM, Mustangin , Zin RR
- KMID: 2422094
- J Pathol Transl Med.
- 2018 Sep;52(5):283-289.
- doi: 10.4132/jptm.2018.08.14
BACKGROUND: Lung cancer is the third most common cancer worldwide. With major advances in the molecular testing of lung cancers and the introduction of targeted therapies, the distinction between adenocarcinoma... -
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- Expression of p63 and its association with cell proliferation at different stages of murine hair follicle cycle
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Lee BW, Oh JW, Seo M, Hwang JS, Yoon B
- KMID: 2436121
- J Biomed Transl Res.
- 2018 Mar;19(1):10-15.
- doi: 10.12729/jbtr.2018.19.1.010
In the present study, we investigated the expression patterns of p63, a member of the p53 gene family, in hair follicle cells at different stages of the hair cycle and... -
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- Immunohistochemical evaluation of p63 and cyclin D1 in oral squamous cell carcinoma and leukoplakia
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Patel SB, Manjunatha BS, Shah V, Soni N, Sutariya R
- KMID: 2393598
- J Korean Assoc Oral Maxillofac Surg.
- 2017 Oct;43(5):324-330.
- doi: 10.5125/jkaoms.2017.43.5.324
OBJECTIVES: There are only a limited number of studies on cyclin D1 and p63 expression in oral squamous cell carcinoma (OSCC) and leukoplakia. This study compared cyclin D1 and p63... -
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- Expression Patterns of Gli-1, Pleckstrin Homology-Like Domain, Family A, Member 1, Transforming Growth Factor-beta1/beta2, and p63 in Sebaceous and Follicular Tumors
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Jeon SY, Kim DC, Song KH, Kim KH
- KMID: 2264866
- Ann Dermatol.
- 2014 Dec;26(6):713-721.
- doi: 10.5021/ad.2014.26.6.713
BACKGROUND: Certain epidermal appendage tumors, including hyperplasias (hamartomas), adenomas, benign epitheliomas, primordial epitheliomas, and malignant tumors, can exhibit any stage of differentiation. Several molecules associated with tumorigenesis, such as Gli-1,... -
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- The prognostic significance of p16, Ki-67, p63, and CK17 expression determined by immunohistochemical staining in cervical intraepithelial neoplasia 1
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Kim SM, Lee JU, Lee DW, Kim MJ, Lee HN
- KMID: 2013233
- Korean J Obstet Gynecol.
- 2011 Apr;54(4):184-191.
- doi: 10.5468/KJOG.2011.54.4.184
OBJECTIVE: To evaluate the prognostic significance of p16, Ki-67, p63, and cytokeratin (CK) 17 expression determined by immunohistochemical staining in cervical intraepithelial neoplasia (CIN) 1. METHODS: Biopsy tissue samples from 33... -
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- Distinction of Pulmonary Large Cell Neuroendocrine Carcinoma from Small Cell Lung Carcinoma Using a Panel of Bcl-2, p63, and 34betaE12
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Li JZ, Choi C, Choi YD, Na KJ
- KMID: 1443750
- Korean J Pathol.
- 2011 Apr;45(2):170-174.
- doi: 10.4132/KoreanJPathol.2011.45.2.170
BACKGROUND: Making the distinction between large cell neuroendocrine carcinoma (LCNEC) and small cell lung carcinoma (SCLC) is difficult in some samples of biopsy tissues, but we have to separate LCNEC... -
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- Expression of p63 and its Isoform, deltaNp63, in Non-Small Cell Lung Carcinoma
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Kim ID, Shin DH, Choi KU, Park DY, Huh GY, Sol MY, Lee MK, Kim YD, Lee CH
- KMID: 2459591
- Korean J Pathol.
- 2009 Aug;43(4):321-328.
BACKGROUND: Several studies have been conducted on the role of the p63 gene family in non-small cell lung carcinoma (NSCLC). Nevertheless, the role of these genes in the development and... -
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- Efficient Cultivation Conditions for Human Limbal Epithelial Cells
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Kim MK, Lee JL, Oh JY, Shin MS, Shin KS, Wee WR, Lee JH, Park KS, Son YS
- KMID: 1783074
- J Korean Med Sci.
- 2008 Oct;23(5):864-869.
- doi: 10.3346/jkms.2008.23.5.864
To compare the stem niche in different culture conditions of limbal epithelial cells, the suspended human limbal epithelial cells (HLECs) were seeded on the 3T3-pretreated plates and the other suspended... -
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- Impaired Delta NP63 Expression is Associated with Poor Tumor Development in Transitional Cell Carcinoma of the Bladder
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He Y, Wu X, Tang W, Tian D, Luo C, Yin Z, Du H
- KMID: 1783068
- J Korean Med Sci.
- 2008 Oct;23(5):825-832.
- doi: 10.3346/jkms.2008.23.5.825
The oncogenic isoform of the p63 protein, delta NP63, plays an important role in the pathogenesis of many epithelial carcinomas, and emerging evidences suggest that delta NP63 is a promising... -
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- Hair Follicular Expression of Integrin Alpha-6 Subunit and p63 in Hair Loss
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Kang H, Lee YJ, Park YM, Kim SY, Kim HO, Lee SD
- KMID: 2302103
- Korean J Dermatol.
- 2008 Feb;46(2):181-188.
BACKGROUND: Integrins have a crucial function in the attachment of cells to the extracellular matrix and as important transducers of signals from the extracellular matrix to the matrix cells of... -
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- Expression of dominant negative p63 isoform in well-differenciated oral squamous cell carcinoma
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Kim IS, Kim CH, Kim KW
- KMID: 2190264
- J Korean Assoc Oral Maxillofac Surg.
- 2007 Jun;33(3):191-198.
The p53 which is well known as tumor suppressor gene is located at 17p13. p53 is a sequence-specific DNA binding transcription factor that responds to certain cytotoxic stresses, such as... -
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- The expression of Ki-67, p63, p53, and p27 as a biological marker for grading cervical intraepithelial neoplasia and cervical carcinoma
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Kim YJ, Lee HJ, Kim SH, Park MH, Cho SH
- KMID: 2273115
- Korean J Obstet Gynecol.
- 2007 Apr;50(4):629-637.
OBJECTIVE: To determine the pattern of expression of p63, p27, and p53 as well as Ki-67 and its efficacy to discriminate the cervical lesion such as intraepithelial lesion, microinvasive carcinoma,... -
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- Expression of p63 in Various Hyperproliferative Skin Diseases
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Han SS, Chang SE, Jung HJ, Lee MW, Choi JH, Moon KC, Koh JK
- KMID: 1881994
- Ann Dermatol.
- 2006 Oct;18(2):64-69.
- doi: 10.5021/ad.2006.18.2.64
The keratinocytes in human epidermis are replaced by a population of stem cells located in the basal layer of the epidermis and one candidate stem cell marker is the transcription... -
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- The Clinicopathologic Significance of a p63 Expression in Invasive Breast Cancer
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Lee SR, Cho JS, Hong KD, Ryu WS, Lee JB, Son GS, Bae JW, Kim AR, Koo BH
- KMID: 1844898
- J Korean Surg Soc.
- 2006 Oct;71(4):243-249.
PURPOSE: p63 is a recently described as p53 homologue. Despite their structural homologies, they have different activities. p63 is a specific myoepithelial cell marker in normal breast tissue and it... -
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- Expression of p63 in Reactive Hyperplasias and Malignant Lymphomas
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Park CK, Oh YH
- KMID: 1781756
- J Korean Med Sci.
- 2005 Oct;20(5):752-758.
- doi: 10.3346/jkms.2005.20.5.752
p63 is a recently described p53 homologue. It is involved in survival and differentiation of reserve/stem cells in epithelia. To obtain new insights into the role of p63 in malignant... -
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- The relationship of p63 expression with cell proliferation and apoptosis in DMBA-induced hamster buccal pouch carcinogenesis
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Park JH, Lee WD, Min CG, Kang JH, Myung H, Lee JH, Kim MJ
- KMID: 2190389
- J Korean Assoc Oral Maxillofac Surg.
- 2005 Jun;31(3):219-227.
PURPOSE: Abnormalities in the p53 gene are regarded as the most consistent genetic abnormalities detected in head and neck squamous cell carcinogenesis. Two new members of the p53 gene family,... -
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- Expression of p63,bcl-2,bcl-6 and p16 in Basal Cell Carcinoma and Squamous Cell Carcinoma of the Skin
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Zheng Z, Kye Y, Zhang X, Kim A, Kim I
- KMID: 2275425
- Korean J Pathol.
- 2005 Apr;39(2):91-98.
BACKGROUND: Basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) are the common malignant neoplasms of the skin. The p63 is a p53 homologue which is considered to be a... -
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- p63 and p73 in Tumor Suppression and Promotion
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McKeon FD
- KMID: 1807301
- Cancer Res Treat.
- 2004 Feb;36(1):6-12.
The recent discovery of two genes, termed p63 and p73, encoding transcription factors highly homologous to p53 presents unexpected challenges and opportunities for the understanding and treatment of cancers. The... -
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- Analysis of Expression of p63 in Cervical Neoplasia Comparing with Other Immunohistochemical Markers
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Kim MY, Cho SH, Park MH
- KMID: 2275537
- Korean J Pathol.
- 2003 Oct;37(5):333-341.
BACKGROUND: The reproducibility in grading a cervical intraepithelial neoplasia (CIN) are not perfect. The aim of this study was to assess the value of the immunohistochemical expression of p63 and... -
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