- Role of Loss of O(6)-Methylguanine DNA Methyltransferase (MGMT) Expression in Non-Small Cell Lung Carcinomas (NSCLCs): with Reference to the Relationship with p53 Overexpression
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Myong NH
- KMID: 2165964
- Cancer Res Treat.
- 2010 Jun;42(2):95-100.
PURPOSE: Functional inactivation of the O(6)-methylguanine-DNA methyltransferase (MGMT) gene has been demonstrated as loss of MGMT protein and suggested that it plays an important role in primary human neoplasia, including... -
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- Expression of Claudin-1, p53 and E-cadherin in Pseudoepitheliomatous Hyperplasia and Squamous Cell Carcinoma of the Head and Neck
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Choi KH, Lim JH, Lee JH, Kwon KS, Lee H, Park HS, Chung MJ, Moon WS, Eun JS, Lee DG, Jang KY
- KMID: 1163217
- Korean J Pathol.
- 2008 Oct;42(5):287-293.
BACKGROUND: Pseudoepitheliomatous hyperplasia (PEH) is a reactive proliferation of surface epithelium and can be confused with invasive squamous cell carcinoma (SCC) in head and neck biopsy specimens. To distinguish PEH... -
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- Regulation of p53 Genes by Ferritin Light Chain: Preliminary Study
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Yi SY
- KMID: 1973943
- Ewha Med J.
- 2008 Jun;31(1):9-14.
- doi: 10.12771/emj.2008.31.1.9
No abstract available in English. -
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- The Clinical Significance of Transforming Growth Factor (TGF) beta1, TGF beta Receptor beta II, p53 Protein and K-ras Point Mutation in Pancreatic Cancer
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Kim KS, Chae YS, Kim JT
- KMID: 2211144
- J Korean Surg Soc.
- 2008 Apr;74(4):274-281.
PURPOSE: Many cancers, including pancreatic cancer, harbor defects in TGF beta signaling and are resistant to TGF beta mediated growth inhibition. In addition, the expression of the p53 gene and... -
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- Genetic Expression Pattern of Gastric Carcinomas According to Cellular Mucin Phenotypes
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Lee WA, Suh IS, Li YH, Eum JH, Yu WS, Bae HI
- KMID: 1521624
- Korean J Pathol.
- 2007 Oct;41(5):307-315.
BACKGROUND: Gastric carcinomas (GCs) have recently been reclassified according to the mucin phenotypes. We aimed to characterize the relationship between the mucin phenotypes and the genetic alterations or the clinicopathologic... -
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- p53 Mutation and p53 Protein Expression in Gastric Cancer Tissues
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Ku KB, Park SH, Chung HY, Yu W, Lee MH
- KMID: 2211067
- J Korean Surg Soc.
- 2007 Apr;72(4):283-289.
PURPOSE: Variable changes occur in the progression from normal gastric epithelium to cancer, including many tumor, tumor suppressor and DNA repair genes, as well as growth factor and its receptors.... -
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- Expression of Mutant p53 Protein, p21(waf1/cip1) and Cyclin D1 in Dysplasia and Adenocarcinoma of Stomach
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Yun KJ, Kim HS, Jo HJ, Choi SC
- KMID: 2304817
- Korean J Gastrointest Endosc.
- 2007 Jan;34(1):9-13.
BACKGROUND/AIMS: Gastric carcinoma is a major cause of morbidity and mortality in Korea. It evolves through dysplasia to an invasive adenocarcinoma. The carcinogenesis of dysplasia and adenocarcinoma in the stomach... -
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- Expression of Survivin in Non-Small Cell Lung Carcinoma: Relationship to Tumor Biology and Prognosis in Surgically Treated Patients
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Jung MJ, Chun BK
- KMID: 1598089
- Korean J Pathol.
- 2005 Jun;39(3):151-157.
BACKGROUND: Survivin, a novel member of inhibitor-of-apoptosis, is undetectable in most terminally differentiated nonproliferative adult tissue, but is overexpressed in some human malignancies. The survivin gene expression is repressed by... -
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- Expression of p53 Protein and Gene in Human Cholesteatoma
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Jung JY, Kim KR, Yu SM, Hong SH, Chung WH, Kim HJ, Cho YS
- KMID: 2276331
- Korean J Otolaryngol-Head Neck Surg.
- 2005 Jan;48(1):18-23.
BACKGROUND AND OBJECTIVES: Migration, hyperproliferation, differentiation of basal keratinocytes and accumulation of keratin debris are the major pathogenic reactions in middle ear cholesteatoma. p53 is a multi-functional protein that acts... -
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- The Expression of c-myc, bcl-2 and p53 Proteins in Adenocarcinomas of Lung
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Yoo J, Jung JH, Choi HJ, Kang SJ, Kang CS
- KMID: 2127915
- Cancer Res Treat.
- 2004 Apr;36(2):146-150.
PURPOSE: c-myc, bcl-2 and p53 are known to regulate apoptosis. There has been growing interest in analyzing their contribution to the pathogenesis and prognosis in a variety of human cancers.... -
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- Detection of Epstein-Barr Virus by PCR and Expression of LMP1, p53, CD44 in Gastric Cancer
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Lee MA, Hong YS, Kang JH, Lee KS, You JY, Lee KY, Park CH
- KMID: 759684
- Korean J Intern Med.
- 2004 Mar;19(1):43-47.
BACKGROUND: Epstein-Barr virus (EBV) is associated with various lymphoproliferative disorders and nasopharyngeal carcinoma. Recently, some gastric cancer cells were observed to contain the EBV sequence. We detected EBV in gastric... -
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- Serum Anti-p53 Antibodies and p53 Protein Expression and Their Prognostic Relevance in Patients with Gastric Cance
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Oh SH, Choi JC, Park TS, Kim HH, Lee EY, Kim HY, Sol MY
- KMID: 2239112
- Korean J Lab Med.
- 2004 Feb;24(1):15-21.
BACKGROUND: Several cancer patients have developed antibodies that recognize the overexpressed p53 protein. In some tumor types, the presence of these antibodies is associated with a poor prognosis. Gastric cancer... -
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- The Clinical Features and Immunoreactivities of p53 and cox-2 in Malignant Meningiomas
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Jeong IH, Jung S, Kang SS, Kim IY
- KMID: 2339769
- J Korean Neurosurg Soc.
- 2003 Dec;34(6):521-525.
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- Correlation between p53 and Rb Protein Expression and Clinicopathologic Features in Hepatocellular Carcinoma
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Gu MJ, Choi JH
- KMID: 1972873
- Cancer Res Treat.
- 2003 Dec;35(6):514-520.
PURPOSE: Hepatocellular carcinomas (HCC) are one of the most common cancers in Korea. The mechanism of HCC development is still unclear, and the aberration of the tumor suppressor genes in... -
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- Clinical Implications of VEGF and p53 Expression in Squamous Cell Carcinoma of the Cervix Treated with Radiation Therapy
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Kang JO, Hong SE, Kang DW
- KMID: 2166162
- Cancer Res Treat.
- 2003 Oct;35(5):440-444.
PURPOSE: The present study was designed to analyze the relationship between vascular endothelial growth factor (VEGF) and p53, and their impact on clinical outcome in squamous cell carcinoma of the... -
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- The Prognostic Significance of Immunohistochemically Detected Isolated Tumor Cells in Lymph Node in Colorectal Cancer
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Lee JS, Lim JW, Choi SK, Chung EJ, Lee YJ, Hong SC, Kwon SI, Park ST, Ha WS
- KMID: 2334278
- J Korean Soc Coloproctol.
- 2002 Oct;18(5):317-323.
PURPOSE: Metastasis of a colorectal carcinoma to regional lymph nodes indicates poor prognosis. The detection of lymph node metastasis is routinely performed by his topathological analysis of hematoxylin-eosin (H&E) stained... -
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- Detection of Epstein-barr virus by PCR and expression of LMP1, p53, CD44 in gastric cancer
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Lee MA, Hong YS, Kang JH, Lee KS, Yoo JY, Lee KY
- KMID: 2252838
- Korean J Med.
- 2002 Sep;63(3):261-266.
BACKGROUND: Epstein-Barr virus (EBV) is associated with various lymphoproliferative disorders and nasopharyngeal carcinoma. Recently some of the tumor cells of gastric cancer were observed to contain EBV sequence. We detected... -
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- The Histologic and Colonoscopic Features and p53 Protein Overexpression of Serrated Adenoma
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Kim SG, Lee MS, Kim JO, Cheon GJ, Jung IS, Cheon YK, Cho JY, Lee JS, Jin SY, Shim CS
- KMID: 2085017
- Korean J Gastroenterol.
- 2002 May;39(5):350-355.
BACKGROUND/AIMS: Serrated adenomas (SA) is a distinct form of colorectal neoplasia, in which adenomatous glands have a serrated epithelial arrangement observed in hyperplastic polyps. SA is defined as a neoplastic... -
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- The alteration of p16 protein in invasive cervical cancer
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Ahn SN, Kim WG
- KMID: 2262709
- Korean J Obstet Gynecol.
- 2002 Apr;45(4):602-609.
OBJECTIVE: Recently p16 gene has been found as a new factor for cervical carcinogenesis. The purpose of this study is to investigate the p16 protein alteration in invasive cervical cancers,... -
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- Expression of P-glycoprotein and p53 Protein in Stage IV Hepatocellular Carcinoma Treated with Systemic Chemotherapy
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Cho SH, Cho HH, Kim YH, Chung J, Choi D, Cho K, Lee JH, Jeong SH, Han CJ, Kim YC, Lee JO, Chung JH, Lee SS
- KMID: 2241234
- Korean J Hepatol.
- 2001 Dec;7(4):459-466.
BACKGROUND/AIMS: Hepatocellular carcinoma (HCC) is a drug-resistant tumor. The expression of a multidrug resistant gene, P-glycoprotein (P-gp) is a major mechanism of drug resistance. The aims of our study were,... -
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