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Small Molecule Drug Candidates for Managing the Clinical Symptoms of COVID-19: a Narrative Review

Yun C, Lee HJ, Lee CJ

Towards the end of 2019, an atypical acute respiratory disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was identified in Wuhan, China and subsequently named Coronavirus disease 2019...
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Vanillin oxime inhibits lung cancer cell proliferation and activates apoptosis through JNK/ERK-CHOP pathway

Shen J, Su Z

Lung cancer despite advancement in the medical field continues to be a major threat to human lives and accounts for a high proportion of fatalities caused by cancers globally. The...
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Global Regulators to Activate Silent Biosynthetic Gene Clusters

Shim SH

Genome mining has recently emerged as a powerful strategy to discover novel microbial secondary metabolites. However, more than 50% of biosynthetic gene clusters are not transcribed under standardized laboratory culture...
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Natural Products Targeting Wnt/β-catenin Signaling Pathway

Kim D, Lee SK

The canonical Wnt/β-catenin signaling pathways play an important role in the embryonic development, cell proliferation, differentiation, and adhesion. Therefore, the abnormal activation and repression have been associated with uncontrolled homeostasis...
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Natural Products as Sources of Novel Drug Candidates for the Pharmacological Management of Osteoarthritis: A Narrative Review

Kang YH, Lee HJ, Lee CJ, Park JS

Osteoarthritis is a chronic degenerative articular disorder. Formation of bone spurs, synovial inflammation, loss of cartilage, and underlying bone restructuring have been reported to be the main pathologic characteristics of...
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Growth Factor- and Phorbol Ester-induced Production and Gene Expression of MUC5AC Mucin in Human Airway Epithelial NCI-H292 Cells Were Inhibited by Afzelin and Natural Products Derived from Houttuynia Cordata

Kim YJ, Lee HJ, Lee CJ

In the present study, we investigated whether quercitrin, quercetin and afzelin derived from Houttuynia cordata affect the production and gene expression of MUC5AC mucin from airway epithelial cells. Confluent NCI-H292...
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Sleep-Aids Derived from Natural Products

Hu Z, Oh S, Ha TW, Hong JT, Oh KW

Although drugs such as barbiturates and benzodiazepines are often used for the treatment of insomnia, they are associated with various side effects such as habituations, tolerance and addiction. Alternatively, natural...
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Ingenol Protects Human T Cells From HIV-1 Infection

Hong KJ, Lee HS, Kim Ys, Kim SS

Objectives Many natural compounds have been investigated as drug candidates to prevent human immunodeficiency virus (HIV) with low cytotoxicity. We tested whether ingenol from Euphorbia ingens exerts anti-HIV effects in human T...
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Effects of Proinflammatory Cytokines and Natural Products on Mucin Release from Cultured Hamster Tracheal Surface Epithelial Cells

Park JS, Kim HS, Seok JH, Hur GM, Park JS, Seo UK, Lee CJ

  • KMID: 1611491
  • Korean J Physiol Pharmacol.
  • 2004 Dec;8(6):329-333.
In this study, we investigated whether TNF-alpha, IL-1beta, CTMA (carboxymethyl trimethylammonium) and LPD (Lup-20[29]-ene-3beta, 28-diol) affect mucin release from airway goblet cells and compared the activities of these agents with...
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Alpha-2 Adrenoceptor Binding Profile of Natural Products Used to Treat Psychotic illnesses

Chung IW, Ahn JS, Lee HS, Park JB, Kim YS

  • KMID: 2287012
  • Korean J Psychopharmacol.
  • 1999 Apr;10(1):50-56.
Natural products have long been major sources of pharmaceutical products in medicine. We have undertaken a series of studies designed to characterize the pharmacologic profiles of natural products used to...
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