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Analysis of Mutant Isocitrate Dehydrogenase 1 Immunoexpression, Ki-67 and Programmed Death Ligand 1 in Diffuse Astrocytic Tumours : Study of Single Center in Bandung, Indonesia

Bolly HMB, Faried A, Hermanto Y, Lubis BP, Tjahjono FP, Hernowo BS, Arifin MZ

Objective : Diffuse astrocytic tumour (DAT) is a diffuse infiltrative astrocytoma tumour accompanied by molecular parameters such as the presence or absence of isocitrate dehydrogenase (IDH) gene mutations. Ki-67 is...
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All-Trans Retinoic Acid Synergizes with Enasidenib to Induce Differentiation of IDH2-Mutant Acute Myeloid Leukemia Cells

Kim Y, Jeung HK, Cheong JW, Song J, Bae SH, Lee JI, Min YH

Purpose: Pharmacological inhibition of mutant isocitrate dehydrogenase (IDH) reduces R-2-hydroxyglutarate (2-HG) levels and restores cellular differentiation in vivo and in vitro. The IDH2 inhibitor enasidenib (AG-221) has been approved by...
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Englerin A-sensing charged residues for transient receptor potential canonical 5 channel activation

Jeong S, Ko J, Kim M, Park KC, Park EY, Kim J, Baik Y, Wie J, Cho AE, Jeon JH, So I

The transient receptor potential canonical (TRPC) 5 channel, known as a nonselective cation channel, has a crucial role in calcium influx. TRPC5 has been reported to be activated by muscarinic...
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Different invasion efficiencies of Brucella abortus wild-type and mutantsin RAW 264.7 and THP-1 phagocytic cells and HeLa non-phagocytic cells

Shim S, Im YB, Jung M, Park WB, Yoo HS

Brucellosis is one of the common zoonoses caused by Brucella abortus (B. abortus). However, little has been reported on factors affecting invasion of B. abortus into host cells. To investigate...
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Cysteine-Added Mutants of Turnip Yellow Mosaic Virus

Shin IS, Kim D, Cho TJ

Native turnip yellow mosaic virus (TYMV) is relatively unreactive to maleimide agents, indicating few reactive thiol groups on TYMV. In the present study, we aimed to construct TYMV mutants that...
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Fragment Analysis for Detection of the FLT3-Internal Tandem Duplication: Comparison with Conventional PCR and Sanger Sequencing

Lee G, Kim J, Lee S, Jang W, Park J, Chae H, Kim M, Kim Y

BACKGROUND: We evaluated a sensitive and quantitative method utilizing fragment analysis of the fms-like tyrosine kinase 3-internal tandem duplication (FLT3-ITD), simultaneously measuring mutant allele burden and length, and verified the...
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Quercetin induces cell death by caspase-dependent and p38 MAPK pathway in EGFR mutant lung cancer cells

Lim EJ, Heo J, Kim YH

OBJECTIVES: The aim of this study was whether quercetin induces cell death by caspase and MAPK signaling pathway in EGFR mutant lung cancer cells. METHODS: PC-9 cells, EGFR mutant lung cancer...
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Elucidating the role of ApxI in hemolysis and cellular damage by using a novel apxIA mutant of Actinobacillus pleuropneumoniae serotype 10

Chang NY, Chen ZW, Chen TH, Liao JW, Lin CC, Chien MS, Lee WC, Lin JH, Hsuan SL

Exotoxins produced by Actinobacillus (A.) pleuropneumoniae (Apx) play major roles in the pathogenesis of pleuropneumonia in swine. This study investigated the role of ApxI in hemolysis and cellular damage using...
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Mutant p53-Notch1 Signaling Axis Is Involved in Curcumin-Induced Apoptosis of Breast Cancer Cells

Bae YH, Ryu JH, Park HJ, Kim KR, Wee HJ, Lee OH, Jang HO, Bae MK, Kim KW, Bae SK

Notch1 has been reported to be highly expressed in triple-negative and other subtypes of breast cancer. Mutant p53 (R280K) is overexpressed in MDA-MB-231 triple-negative human breast cancer cells. The present...
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Performance Evaluation of Immunoassay Detection of HBsAg Mutants and Their Clinical Significance in the High Risk Groups

Choi JI, Lim JH, Jeong J, Lee SH, Park JS, Park NH, Shin JW, Nah YW, Nam CW, Cha YJ, Kim SR

  • KMID: 2312217
  • Lab Med Online.
  • 2013 Apr;3(2):88-96.
BACKGROUND: False negative results have been reported in the immunodetection of hepatitis B virus (HBV) because of the existence of the various mutants of the virus, causing most suppliers to...
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Lon Mutant of Brucella abortus Induces Tumor Necrosis Factor-Alpha in Murine J774.A1 Macrophage

Park S, Choi YS, Park SH, Kim YR, Chu H, Hwang KJ, Park MY

Objectives The objective of this study was to isolate a Brucella lon mutant and to analyze the cytokine response of B. lon mutant during macrophage infection. Methods A wild-type Brucella abortus strain was...
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Development and evaluation of protective capacity of Salmonella Enteritidis polyphosphate kinase-deleted and temperature-sensitive mutant

Kim K, Park S, Cho Y, Kwak JY, Kang ZW, Kim EH, Choi HW, Won HK, Noh YH, Hahn TW

  • KMID: 1790567
  • Korean J Vet Res.
  • 2013 Dec;53(4):211-216.
This study was focusing on evaluating the protection of polyphosphate kinase (ppk) deleted and/or temperature-sensitive (ts) Salmonella Enteritidis (SE) as an attenuated vaccine in chickens. We constructed SEppk, SEts and...
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Inactivated pep27 mutant as an effective mucosal vaccine against a secondary lethal pneumococcal challenge in mice

Choi SY, Tran TD, Briles DE, Rhee DK

  • KMID: 2391977
  • Clin Exp Vaccine Res.
  • 2013 Jan;2(1):58-65.
PURPOSE: A pep27 mutant may be able to elicit mucosal immunity against pneumococcal diseases, and could be employed as an inexpensive attenuated vaccine. However, this particular mutant contains an erythromycin-resistance...
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Identification of a Rare 3 bp BRAF Gene Deletion in a Thyroid Nodule by Mutant Enrichment with 3'-Modified Oligonucleotides Polymerase Chain Reaction

Jang MA, Lee ST, Oh YL, Kim SW, Chung JH, Ki CS, Kim JW

Papillary thyroid carcinoma (PTC) is the most common malignant thyroid tumor, and 36-69% of PTC cases are caused by mutations in the BRAF gene. The substitution of a valine for...
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Generation and Biological Characterization of a Neutralization-Resistant Mutant of Newcastle Disease Virus

Park MJ, Kye SJ, Kim JY, Kim S, Seul HJ, Park CK, Choi KS

A neutralization-resistant mutant of Newcastle disease virus (NDV) Kr005 strain belonging to class II genotype VII was generated using a neutralizing monoclonal antibody and its biological effects were assessed. The...
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Altered Synthesis of Cartilage-Specific Proteoglycans by Mutant Human Cartilage Oligomeric Matrix Protein

Kwak YH, Roh JY, Lee KS, Park HW, Kim HW

BACKGROUND: The mechanism by which mutant cartilage oligomeric matrix protein (COMP) induces a pseudoachondroplasia phenotype remains unknown, and the reason why a mutation of a minor protein of the growth...
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A case report of treatment with pegylated interferon alpha for lamivudine-resistant chronic hepatitis B virus infection

Hur WH, Woo HY, Jeong SW, You CR, Bae SH, Choi JY, Yoon SK

The wide use of lamivudine in chronic hepatitis B has produced a monotonic increase in patients with lamivudine resistance. Therefore, treating lamivudine resistance in chronic hepatitis B is a major...
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Hepatitis B virus genetic diversity and mutant

Yim HJ

Hepatitis B virus (HBV) is a partially double stranded DNA virus with genetic diversity represented by eight genotypes (A to H). Natural course and response to treatment could be affected...
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A point mutant of apolipoprotein A-I, V156K, exhibited potent anti-oxidant and anti-atherosclerotic activity in hypercholesterolemic C57BL/6 mice

Cho KH, Park SH, Han JM, Kim HC, Chung YJ, Choi I, Kim JR

  • KMID: 1094656
  • Exp Mol Med.
  • 2007 Apr;39(2):160-169.
In our previous study, two point mutants of apolipoprotein A-I, designated V156K and A158E, revealed peculiar characteristics in their lipid-free and lipid-bound states. In order to determine the putative therapeutic...
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Mutant Prevention Concentration of Polymyxin B for the Clinical Isolates of Pseudomonas aeruginosa

Choi CU, Seo MR, Lim YH, Pai H

  • KMID: 2285063
  • Infect Chemother.
  • 2006 Dec;38(6):344-348.
BACKGROUND: Infection caused by multi-drug resistant (MDR) Gram-negative organisms such as Pseudomonas and Acinetobacter species is one of emerging important problems in modern hospitals. To treat multi-drug resistant non-fermenting Gram-negatives,...
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