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Comparison of digital PCR platforms using the molecular marker

Lee CJ, Shin W, Song M, Shin SS, Park Y, Srikulnath K, Kim DH, Han K

Assays of clinical diagnosis and species identification using molecular markers are performed according to a quantitative method in consideration of sensitivity, cost, speed, convenience, and specificity. However, typical polymerase chain...
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Monitoring antimalarial drug-resistance markers in Somalia

The use of an effective antimalarial drug is the cornerstone of malaria control. However, the development and spread of resistant Plasmodium falciparum strains have placed the global eradication of malaria...
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Molecular Markers for Sulfadoxine/Pyrimethamine and Chloroquine Resistance in Plasmodium falciparum in Thailand

Kuesap J, Suphakhonchuwong N, Kalawong L, Khumchum N

Drug resistance is an important problem hindering malaria elimination in tropical areas. Point mutations in Plasmodium falciparum dihydrofolate reductase (Pfdhfr) and dihydropteroate synthase (Pfdhps) genes confer resistance to antifolate drug,...
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Pre- and Post-Treatment Imaging of Primary Central Nervous System Tumors in the Molecular and Genetic Era

Ahn SS, Cha S

Recent advances in the molecular and genetic characterization of central nervous system (CNS) tumors have ushered in a new era of tumor classification, diagnosis, and prognostic assessment. In this emerging...
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Metastasis prognostic factors and cancer stem cell-related transcription factors associated with metastasis induction in canine metastatic mammary gland tumors

Kim S, Bok E, Lee S, Lee HJ, Choe Y, Kim NH, Lee WJ, Rho GJ, Lee SL

Background Canine mammary gland tumor (MGT) is the most common cancer in aged female dogs. Although it's important to identify reliable metastasis or prognostic factors by evaluating related to cell division,...
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Distinctive morphological and molecular features of urothelial carcinoma with an inverted growth pattern

Sanguedolce F, Calò B, Chirico M, Falagario U, Busetto GM, Zanelli M, Bisagni A, Zizzo M, Ascani S, Carrieri G, Cormio L

Urothelial carcinoma with an inverted growth pattern (UC-IGP) is a peculiar entity within the spectrum of urothelial lesions. While efforts have been made over the last few decades to unravel...
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Molecular Markers for Detecting a Wide Range of Trichoderma spp. that Might Potentially Cause Green Mold in Pleurotus eryngii

Lee SH, Jung HJ, Hong SB, Choi JI, Ryu JS

In Pleurotus sp., green mold, which is considered a major epidemic, is caused by several Trichoderma species. To develop a rapid molecular marker specific for Trichoderma spp. that potentially cause...
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Use of adverse outcome pathways in chemical toxicity testing: potential advantages and limitations

Jeong J, Choi J

Amid revolutionary changes in toxicity assessment brought about by increasing regulation of chemicals, adverse outcome pathways (AOPs) have emerged as a useful framework to assess adverse effect of chemicals using...
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Protein Phosphatase Magnesium-Dependent 1δ (PPM1D) Expression as a Prognostic Marker in Adult Supratentorial Diffuse Astrocytic and Oligodendroglial Tumors

Jeong HJ, Woo CG, Lee B, Khang SK, Nam SJ, Choi J

BACKGROUND: Protein phosphatase magnesium-dependent 1δ (PPM1D) is a p53-induced serine/threonine phosphatase, which is overexpressed in various human cancers. A recent study reported that a mutation in the PPM1D gene is...
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Current Pathological and Laboratory Considerations in the Diagnosis of Disseminated Intravascular Coagulation

Toh CH, Alhamdi Y, Abrams ST

Systemically sustained thrombin generation in vivo is the hallmark of disseminated intravascular coagulation (DIC). Typically, this is in response to a progressing disease state that is associated with significant cellular...
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Immunohistochemical and Molecular Markers Associated with Differentiated Thyroid Carcinoma

Jung JW, Choi JY, Lee KE, Park KW

In the last decade, conventional diagnosis of thyroid nodules largely depended on fine-needle aspiration (FNA) and ultrasound. However, FNA has a limited ability to distinguish between benign and malignant lesions,...
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Molecular Markers for Identification of Stellantchasmus falcatus and a Phylogenic Study using the HAT-RAPD Method

Wongsawad , Wongsawad

Stellantchasmus falcatus is a minute intestinal fluke in the family Heterophyidae. Metacercariae, the infective stage, were reported in a marine fish, mullet Liza subviridis, and a fresh water fish, Dermogenus...
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Genomic Instability in Colorectal Cancer; from Bench to Bed

Lee KY

  • KMID: 2334430
  • J Korean Soc Coloproctol.
  • 2009 Apr;25(2):129-138.
Colorectal cancer is a disease developed by the accumulation of genomic alteration. Two genomic instability pathways, chromosomal instability pathway and microsatellite instability pathway, are known as the main pathways of...
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Galectin-3 and Thyroid Peroxidase Expression in Thyroid Nodules

Bae GH, Yoon HD, Bae JY, Son HS, Jung ED, Hong SP, Kim MH, Lee SA, Kim HS, Ahn SY

BACKGROUND: The accurate diagnosis of a thyroid nodule is important in deciding a patient's treatment plan and for predicting the prognosis. The histopathological diagnosis of resected specimens are largely positively...
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Osteosarcoma: Biologic Markers in Its Treatment

Kim HS

Osteosarcoma is a primary malignant bone tumor that accounts for 5% of childhood cancers. Despite the use of chemotherapy, long-term survival has reached a plateau, and this figure has not...
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Molecular markers associated with radiation resistance and new molecular agents

Bae DS

  • KMID: 2272912
  • Korean J Obstet Gynecol.
  • 2006 Nov;49(11):2243-2252.
Radiation therapy is a key modality in the management of a majority of patients diagnosed with cancer. To know prognostic markers related radiation response can aid in refining our treatment...
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Analysis for Prognostic Factors of Postoperative Stage I Non-small Cell Lung Cancer

Park CK, Park H, Keum DY, Kang YN

  • KMID: 2005743
  • J Lung Cancer.
  • 2004 Dec;3(2):71-76.
OBJECTIVE: This study is to evaluate several histopathologic variables and molecular markers in patients with stage I NSCLC after complete tumor resection to assess their prognostic value. MATERIALS AND METHODS:...
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Breeding of Flammulina velutipes Strains Adaptable to Elevated-temperature

Kong WS, Cho YH, Jhune CS, Yoo YB, Kim KH

  • KMID: 2312425
  • Mycobiology.
  • 2004 Mar;32(1):11-16.
Winter mushroom, Flammulina velutipes, needs low temperature during its cultivation. To save on farm costs, especially during summer, a strain adaptable to a higher or elevated-temperature must be developed. At...
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Molecular Marker Related to Fruitbody Color of Flammulina velutipes

Kong WS, You CH, Yoo YB, Kim GH, Kim KH

  • KMID: 2312424
  • Mycobiology.
  • 2004 Mar;32(1):6-10.
White and brown strains of Flammulina velutipes were inter-crossed. All F1 showed light-brown fruitbody, suggesting that a gene for the brown fruitbody was incompletely dominant against the white one. And...
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Ductal Carcinoma In Situ (DCIS) of the Breast; Clinico-pathological Analysis, Expression of Molecular Markers, and Correlations between Known Prognostic Factors

Kang SS, Ko SS, Jo BH, Hur MH, Lee HK, Lee SK, Chun YK, Kim YJ, Lee KS, Hong SR, Lee JH

  • KMID: 1896424
  • J Korean Surg Soc.
  • 2003 Apr;64(4):289-295.
PURPOSE: The improved availability of breast cancer screening, including mammography, has dramatically increased the detection rate of DCIS (ductal carcinoma in situ). However, there has been controversy regarding the clinico-pathological...
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