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Effects of isorhamnetin on the regulation of mitochondrial function in C2C12 muscle cells

Lee MS, Kim Y

Purpose: Muscle mitochondria play a key role in regulating fatty acid and glucose metabolism. Dysfunction of muscle mitochondria is associated with metabolic diseases such as obesity and type 2 diabetes....
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MPV17-related Hepatocerebral Mitochondrial DNA Depletion Syndrome

Hong KT, Lim BC, Moon JS, Ko JS

Mitochondrial DNA (mtDNA) depletion syndrome comprises diseases resulting from a deficiency of proteins involved in mtDNA synthesis. MPV17 is a mitochondrial membrane protein whose mutation causes mitochondrial deoxynucleotide insufficiency. MPV17-related hepatocerebral...
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Sequencing and annotation of the complete mitochondrial genome of a threatened labeonine fish, Cirrhinus reba

Islam MN, Sultana S, Alam MJ

The mitochondrial genome of a species is an essential resource for its effective conservation and phylogenetic studies. In this article, we present sequencing and characterization of the complete mitochondrial genome...
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Cilostazol ameliorates diabetic nephropathy by inhibiting highglucose- induced apoptosis

Chian CW, Lee YS, Lee YJ, Chen YH, Wang CP, Lee WC, Lee HJ

Diabetic nephropathy (DN) is a hyperglycemia-induced progressivedevelopment of renal insufficiency. Excessive glucose can increase mitochondrialreactive oxygen species (ROS) and induce cell damage, causing mitochondrial dysfunction.Our previous study indicated that cilostazol...
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Analysis of Asian Mitochondrial DNA Haplogroups Associated With the Progression of Knee Osteoarthritis in Koreans

Koo BS, Song Y, Lee S, Sung YK, Shin KJ, Cho NH, Jun JB

Objective. We investigated Asian mitochondrial DNA (mtDNA) haplogroups associated with knee osteoarthritis (OA) progression in a prospective community-based cohort comprised of Koreans. Methods. Epidemiologic data and Kellgren-Lawrence (K/L) scores of...
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Alteration of mitochondrial DNA content modulates antioxidant enzyme expressions and oxidative stress in myoblasts

Min KH, Lee W

Mitochondrial dysfunction is closely associated with reactive oxygen species (ROS) generation and oxidative stress in cells. On the other hand, modulation of the cellular antioxidant defense system by changes in...
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Mitochondrial DNA Analysis of the Human Skeletons from Goryeo Dynasty Graves Discovered at Youngwol, Gangwon-do

Oh CS, Hong JH, Shin DH

In archaeological excavation sites in Korea, human skeletal remains of various periods were discovered. However, there have been very few studies on skeletal cases of Goryeo period so far. Therefore,...
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Association of mitochondrial haplogroup F with physical performance in korean population

Hwang IW, Kim K, Choi EJ, Jin HJ

Athletic performance is a complex multifactorial trait involving genetic and environmental factors. The heritability of an athlete status was reported to be about 70% in a twin study, and at...
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Detection of Innate and Artificial Mitochondrial DNA Heteroplasmy by Massively Parallel Sequencing: Considerations for Analysis

Kim MY, Cho S, Lee JH, Seo HJ, Lee SD

BACKGROUND: Mitochondrial heteroplasmy, the co-existence of different mitochondrial polymorphisms within an individual, has various forensic and clinical implications. But there is still no guideline on the application of massively parallel...
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Mitochondrial 10398A>G NADH-Dehydrogenase Subunit 3 of Complex I Is Frequently Altered in Intra-Axial Brain Tumors in Malaysia

Mohamed Yusoff AA, Zulfakhar , Mohd Khair SZN, Wan Abdullah WS, Abdullah J, Idris Z

BACKGROUND: Mitochondria are major cellular sources of reactive oxygen species (ROS) generation which can induce mitochondrial DNA damage and lead to carcinogenesis. The mitochondrial 10398A>G alteration in NADH-dehydrogenase subunit 3...
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Leigh Syndrome: Subgroup Aanalysis according to Mitochondrial DNA Mutation

Jee NL, Her SM, Kim SH, Lee MJ, Lee CH, Lee YM

PURPOSE: Leigh syndrome (LS) is a rare, progressive neurodegenerative disorder with characteristic abnormalities in the central nervous system. Such patients present with heterogeneous clinical symptoms and genetic abnormalities; thus, prognosis...
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Association between Salivary Mitochondrial DNA Copy Number and Chronic Fatigue according to Combined Symptoms in Korean Adults

Shin J, Kim KC, Lee DC, Lee HR, Shim JY

BACKGROUND: We examined the association between salivary mitochondrial DNA (mtDNA) copy number and chronic fatigue combined with depression and insomnia. METHODS: This cross-sectional study included 58 healthy adults with moderate to...
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Entire Mitochondrial DNA Sequencing on Massively Parallel Sequencing for the Korean Population

Park S, Cho S, Seo HJ, Lee JH, Kim MY, Lee SD

Mitochondrial DNA (mtDNA) genome analysis has been a potent tool in forensic practice as well as in the understanding of human phylogeny in the maternal lineage. The traditional mtDNA analysis...
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Analysis of Nuclear Mitochondrial DNA Segments of Nine Plant Species: Size, Distribution, and Insertion Loci

Ko YJ, Kim S

Nuclear mitochondrial DNA segment (Numt) insertion describes a well-known phenomenon of mitochondrial DNA transfer into a eukaryotic nuclear genome. However, it has not been well understood, especially in plants. Numt...
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Leigh Syndrome in Childhood: Neurologic Progression and Functional Outcome

Lee JS, Kim H, Lim BC, Hwang H, Choi J, Kim KJ, Hwang YS, Chae JH

BACKGROUND AND PURPOSE: Few studies have analyzed the clinical course and functional outcome in Leigh syndrome (LS). The aim of this study was to determine the clinical, radiological, biochemical, and...
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Complete Mitochondrial Genome of Echinostoma hortense (Digenea: Echinostomatidae)

Liu ZX, Zhang Y, Liu YT, Chang QC, Su X, Fu X, Yue DM, Gao Y, Wang CR

Echinostoma hortense (Digenea: Echinostomatidae) is one of the intestinal flukes with medical importance in humans. However, the mitochondrial (mt) genome of this fluke has not been known yet. The present...
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Identification of causative mutations in patients with Leigh syndrome and MERRF by mitochondrial DNA-targeted next-generation sequencing

Hong HD, Kim E, Nam SH, Yoo DH, Suh BC, Choi BO, Chung KW

PURPOSE: Mitochondrial diseases are clinically and genetically heterogeneous disorders, which make their exact diagnosis and classification difficult. The purpose of this study was to identify pathogenic mitochondrial DNA (mtDNA) mutations...
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Effects of chronic alcohol and excessive iron intake on mitochondrial DNA damage in the rat liver

Park JE, Lee JR, Chung J

PURPOSE: In this study, we investigated the effects of chronic alcohol and excessive iron intake on mitochondrial DNA (mtDNA) damage and the progression of alcoholic liver injury in rats. METHODS: Twenty-four...
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Mitochondrial DNA 4977bp Deletion Mutation in Peripheral Blood Reflects Atrial Remodeling in Patients with Non-Valvular Atrial Fibrillation

Lee JS, Ko YG, Shin KJ, Kim SK, Park JH, Hwang KC, Pak HN

PURPOSE: Recently, mitochondrial DNA 4977bp deletion (mtDNA4977-mut), a somatic mutation related to oxidative stress, has been shown to be associated with atrial fibrillation (AF). We hypothesized that patient age, as...
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Statistical Evaluation of Lineage Markers in Individual Identification

Lee HJ, Lee SD, Lee SH, Park SJ, Jeong SJ, Lee JW

Mitochondrial DNA (mt DNA) and the non-recombining region of the Y chromosome are passed down, unaltered, from generation to generation, matrilineally and patrilineally, respectively. Therefore, the Y-chromosome DNA and mtDNA...
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