- Comparison of immunophenotypes between Rag2 knockout mice derived from two different sources
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Roh Y, Gong J, Kim J, Jin Y, Song H, Seol A, Park J, Lim Y, Hwang D
- KMID: 2541303
- Lab Anim Res.
- 2023 Mar;39(1):12-25.
- doi: 10.1186/s42826-023-00153-8
Background Recombination activating gene2 (Rag2) knockout (KO) mice are used widely in various research fields, including vaccine development, transplantation studies, and hematopoiesis research, but few studies have compared their phenotypes. This... -
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- Generation of Astrocyte-Specific MAOB Conditional Knockout Mouse with Minimal Tonic GABA Inhibition
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Lee JM, Sa M, An H, Kim JMJ, Kwon J, Yoon BE, Lee CJ
- KMID: 2531119
- Exp Neurobiol.
- 2022 Jun;31(3):158-172.
- doi: 10.5607/en22016
Monoamine oxidase B (MAOB) is a key enzyme for GABA production in astrocytes in several brain regions. To date, the role of astrocytic MAOB has been studied in MAOB null... -
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- Extract of Curcuma zedoaria R. prevents atherosclerosis in apolipoprotein E-deficient mice
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Kim KM, Lee JY, Jeon BH, Quan KT, Na M, Nam KW, Chae S
- KMID: 2516071
- Nutr Res Pract.
- 2021 Jun;15(3):319-328.
- doi: 10.4162/nrp.2021.15.3.319
BACKGROUND/OBJECTIVES: Curcuma zedoaria R. (Zingiberaceae) has been used to treat headache, fever, and hypertension-related symptoms in Asian countries, including Korea, China, and Japan. We investigated whether dietary intake of a... -
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- C1qa deficiency in mice increases susceptibility to mouse hepatitis virus A59 infection
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Kim HW, Seo SM, Kim JY, Lee JH, Lee HW, Choi YK
- KMID: 2516198
- J Vet Sci.
- 2021 May;22(3):e36.
- doi: 10.4142/jvs.2021.22.e36
Background: Mouse hepatitis virus (MHV) A59 is a highly infectious pathogen and starts in the respiratory tract and progresses to systemic infection in laboratory mice. The complement system is an... -
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- MondoA Is Required for Normal Myogenesis and Regulation of the Skeletal Muscle Glycogen Content in Mice
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Ran H, Lu Y, Zhang Q, Hu Q, Zhao J, Wang K, Tong X, Su Q
- KMID: 2516345
- Diabetes Metab J.
- 2021 May;45(3):439-451.
- doi: 10.4093/dmj.2019.0212
Background Skeletal muscle is the largest tissue in the human body, and it plays a major role in exerting force and maintaining metabolism homeostasis. The role of muscle transcription factors in... -
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- Nuclear Factor Erythroid 2-related Factor 2 Knockout Suppresses the Development of Aggressive Colorectal Cancer Formation Induced by Azoxymethane/Dextran Sulfate Sodium-Treatment in Female Mice
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Song CH, Kim N, Nam RH, Choi SI, Kang C, Jang JY, Nho H, Shin E, Lee HN
- KMID: 2514694
- J Cancer Prev.
- 2021 Mar;26(1):41-53.
- doi: 10.15430/JCP.2021.26.1.41
Colon tumors develop more frequently in male than in female. Nuclear factor erythroid 2-related factor 2 (Nrf2) plays differential roles in the stage of tumorigenesis. The purpose of this study... -
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- Rapid Way to Generate Mouse Models for In Vivo Studies of the Endothelium
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Lee H
- KMID: 2512928
- J Lipid Atheroscler.
- 2021 Jan;10(1):24-41.
- doi: 10.12997/jla.2021.10.1.24
A single layer of squamous endothelial cells (ECs), the endothelium, regulates the flow of substance and fluid into and out of a tissue. The endothelium is also involved in vasculogenesis,... -
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- Coordination of Multiple Cellular Processes by NR5A1/Nr5a1
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Morohashi Ki, Inoue M, Baba T
- KMID: 2511002
- Endocrinol Metab.
- 2020 Dec;35(4):756-764.
- doi: 10.3803/EnM.2020.402
The agenesis of the gonads and adrenal gland in revealed by knockout mouse studies strongly suggested a crucial role for Nr5a1 (SF-1 or Ad4BP) in organ development. In relation to... -
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- Anti-colonic Inflammation by Black Raspberries through Regulating Toll-like Receptor-4 Signaling in Interlukin-10 Knockout Mice
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Huang YW, Echeveste CE, Oshima K, Zhang J, Yearsley M, Yu J, Wang LS
- KMID: 2503568
- J Cancer Prev.
- 2020 Jun;25(2):119-125.
- doi: 10.15430/JCP.2020.25.2.119
Ulcerative colitis (UC) is a chronic inflammatory disease of the colon, with a steadily rising prevalence in Western and newly industrialized countries. UC patients have a cancer incidence as high... -
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- ATG5 knockout promotes paclitaxel sensitivity in drug-resistant cells via induction of necrotic cell death
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Hwang SH, Yeom H, Lee M
- KMID: 2502505
- Korean J Physiol Pharmacol.
- 2020 May;24(3):233-240.
- doi: 10.4196/kjpp.2020.24.3.233
Autophagy regulators are often effective as potential cancer therapeutic agents. Here, we investigated paclitaxel sensitivity in cells with knockout (KO) of ATG5 gene. The ATG5 KO in multidrug resistant v-Ha-ras... -
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- Recent updates on the basic mechanisms and pathogenesis of inflammatory bowel diseases in experimental animal models
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Mizoguchi , Low D, Ezaki Y, Okada T
- KMID: 2501381
- Intest Res.
- 2020 Apr;18(2):151-167.
- doi: 10.5217/ir.2019.09154
The specific pathogenesis underlining inflammatory bowel disease (IBD) is very complicated, and it is further more difficult to clearly explain the pathophysiology of 2 major forms of IBD, Crohn’s disease... -
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- Mesenchymal Stem Cells Decrease Oxidative Stress in the Bowels of Interleukin-10 Knockout Mice
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Jung KJ, Lee GW, Park CH, Lee TJ, Kim JY, Sung EG, Kim SY, Jang BI, Song IH
- KMID: 2508717
- Gut Liver.
- 2020 Jan;14(1):100-107.
- doi: 10.5009/gnl18438
Background/Aims: Inflammatory bowel disease (IBD) is an autoimmune disease characterized by chronic inflammation mainly in the large intestine. The interleukin-10 knockout (IL-10 KO) mouse is a well-known animal model of... -
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- Disruption of the Tff1 gene in mice using CRISPR/Cas9 promotes body weight reduction and gastric tumorigenesis
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Kim H, Jeong H, Cho Y, Lee J, Nam KT, Lee HW
- KMID: 2459303
- Lab Anim Res.
- 2018 Dec;34(4):257-263.
- doi: 10.5625/lar.2018.34.4.257
Trefoil factor 1 (TFF1, also known as pS2) is strongly expressed in the gastrointestinal mucosa and plays a critical role in the differentiation of gastric glands. Since approximately 50% of... -
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- Collagen-Induced Arthritis Analysis in Rhbdf2 Knockout Mouse
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Lee MY, Kang JS, Go RE, Byun YS, Wi YJ, Hwang KA, Choi JH, Kim HC, Choi KC, Nam KH
- KMID: 2421739
- Biomol Ther.
- 2018 May;26(3):298-305.
- doi: 10.4062/biomolther.2017.103
Rhomboid family member 2 gene (Rhbdf2) is an inactive homologue lacking essential catalytic residues of rhomboid intramembrane serine proteases. The protein is necessary for maturation of tumor necrosis factor-alpha (TNF-α)... -
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- Can oliceridine (TRV130), an ideal novel µ receptor G protein pathway selective (µ-GPS) modulator, provide analgesia without opioid-related adverse reactions?
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Ok HG, Kim SY, Lee SJ, Kim TK, Huh BK, Kim KH
- KMID: 2410828
- Korean J Pain.
- 2018 Apr;31(2):73-79.
- doi: 10.3344/kjp.2018.31.2.73
All drugs have both favorable therapeutic and untoward adverse effects. Conventional opioid analgesics possess both analgesia and adverse reactions, such as nausea, vomiting, and respiratory depression. The opioid ligand binds... -
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- Transgenesis for pig models
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Yum SY, Yoon KY, Lee CI, Lee BC, Jang G
- KMID: 2413124
- J Vet Sci.
- 2016 Sep;17(3):261-268.
- doi: 10.4142/jvs.2016.17.3.261
Animal models, particularly pigs, have come to play an important role in translational biomedical research. There have been many pig models with genetically modifications via somatic cell nuclear transfer (SCNT).... -
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- Multi-phenotypic Role of Serum Response Factor in the Gastrointestinal System
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Ro S
- KMID: 2203569
- J Neurogastroenterol Motil.
- 2016 Apr;22(2):193-200.
- doi: 10.5056/jnm15183
Serum response factor (SRF) is a master transcription factor of the actin cytoskeleton that binds to highly conserved CArG boxes located within the majority of smooth muscle cell (SMC)-restricted promoters/enhancers.... -
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- Production of α1,3-galactosyltransferase targeted pigs using transcription activator-like effector nuclease-mediated genome editing technology
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Kang JT, Kwon DK, Park AR, Lee EJ, Yun YJ, Ji DY, Lee K, Park KW
- KMID: 2363339
- J Vet Sci.
- 2016 Mar;17(1):89-96.
- doi: 10.4142/jvs.2016.17.1.89
Recent developments in genome editing technology using meganucleases demonstrate an efficient method of producing gene edited pigs. In this study, we examined the effectiveness of the transcription activator-like effector nuclease... -
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- Propylthiouracil, Perchlorate, and Thyroid-Stimulating Hormone Modulate High Concentrations of Iodide Instigated Mitochondrial Superoxide Production in the Thyroids of Metallothionein I/II Knockout Mice
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Duan Q, Wang T, Zhang N, Perera V, Liang X, Abeysekera IR, Yao X
- KMID: 2169710
- Endocrinol Metab.
- 2016 Mar;31(1):174-184.
- doi: 10.3803/EnM.2016.31.1.174
BACKGROUND: Increased oxidative stress has been suggested as one of the underlying mechanisms in iodide excess-induced thyroid disease. Metallothioneins (MTs) are regarded as scavengers of reactive oxygen species (ROS) in... -
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- Expression of pancreatic and duodenal homeobox1 (PDX1) protein in the interior and exterior regions of the intestine, revealed by development and analysis of Pdx1 knockout mice
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Hashimoto , Kamisako T, Kagawa T, Haraguchi , Yagoto M, Takahashi , Kawai K, Suemizu H
- KMID: 2053683
- Lab Anim Res.
- 2015 Jun;31(2):93-98.
- doi: 10.5625/lar.2015.31.2.93
We developed pancreatic and duodenal homeobox1 (Pdx1) knockout mice to improve a compensatory hyperinsulinemia, which was induced by hyperplasia in the beta cells or Langerhans' islands, as the diabetic model... -
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