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Sweroside plays a role in mitigating high glucose-induced damage in human renal tubular epithelial HK-2 cells by regulating the SIRT1/NF-κB signaling pathway

Ma X, Guo Z, Zhao W, Chen L

Sweroside is a natural monoterpene derived from Swertia pseudochinensis Hara. Recently, studies have shown that sweroside exhibits a variety of biological activities, such as anti-inflammatory, antioxidant, and hypoglycemic effects. However, its...
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Cornuside inhibits glucose-induced proliferation and inflammatory response of mesangial cells

Li X, Guo L, Huang F, Xu W, Peng G

Cornuside is a secoiridoid glucoside compound extracted from the fruits of Cornus officinalis. Cornuside has immunomodulatory and anti-inflammatory properties; however, its potential therapeutic effects on diabetic nephropathy (DN) have not...
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Effects of aging on accompanying intermittent hypoxia in a bleomycin-induced pulmonary fibrosis mouse model

Lee H, Kim IK, Im J, Jin BS, Kim HH, Kim SW, Yeo CD, Lee SH

Background/Aims: Obstructive sleep apnea (OSA) is prevalent in older patients with idiopathic pulmonary fibrosis (IPF); however, it is underrecognized. OSA is characterized by intermittent hypoxia (IH) and sleep fragmentation. In...
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Neutrophil to Lymphocyte Ratio and Serum Biomarkers : A Potential Tool for Prediction of Clinically Relevant Cerebral Vasospasm after Aneurysmal Subarachnoid Hemorrhage

Kula O, Günay B, Kayabaş MY, Aktürk Y, Kula E, Tütüncüler B, Süt N, Solak S

Objective : Subarachnoid hemorrhage (SAH) is a condition characterized by bleeding in the subarachnoid space, often resulting from the rupture of a cerebral aneurysm. Delayed cerebral ischemia caused by vasospasm...
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Regenerative Treatment with Extracellular Vesicles for Spinal Cord Injury

Park WT, Lim YJ, Lee GW

A spinal cord injury (SCI) is a serious condition and can cause permanent disability with a substantial loss of nerve functions (e.g., motor, sensory, etc.). SCI is associated with a...
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Helicobacter pylori-associated Chronic Atrophic Gastritis and Progression of Gastric Carcinogenesis

Lim NR, Chung WC

Chronic inflammation due to a Helicobacter pylori (H. pylori) infection is a representative cause of gastric cancer that can promote gastric carcinogenesis by abnormally activating immune cells and increasing the...
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Neuroplastic and Pro-cognitive Effects of Granulocyte Colony Stimulating Factor in Healthy Adults: A Pilot Study

Wang SM, Kang DW, Kim HJ, Park SS, Lim HK

Objective Granulocyte colony-stimulating factor (G-CSF) is a growth factor used to regulate the mobilization of bone marrow progenitor cells and has been shown to promote brain repair and reduce inflammation....
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The Impact of Taurine on Obesity-Induced Diabetes Mellitus: Mechanisms Underlying Its Effect

Ahmed K, Choi HN, Yim JE

This review explores the potential benefits of taurine in ameliorating the metabolic disorders of obesity and type 2 diabetes (T2D), highlighting the factors that bridge these associations. Relevant articles and...
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Antioxidant and anti-inflammatory effects and mechanism of Abeliophyllum distichum leaf extract in RAW264.7 macrophages

Yoo J, Kim KA

Purpose: Abeliophyllum distichum (A.distichum) is a plant native to Korea. In this study, we investigated the mechanism of antioxidant and anti-inflammatory effects of the leaf extract of A.distichum. Methods: The antioxidant...
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pH/Temperature Responsive Curcumin-Loaded Micelle Nanoparticles Promote Functional Repair after Spinal Cord Injury in Rats via Modulation of Inflammation

Qian T, Li Z, Shang L, Huang S, Li G, Zheng W, Mao Y

BACKGROUND: The formation of an inhibitory inflammatory microenvironment after spinal cord injury (SCI) remains a great challenge for nerve regeneration. The poor local microenvironment exacerbates nerve cell death; therefore, the...
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Short-term Efficacy and Safety of Intravitreal Brolucizumab Injection for Treatment-Naive Exudate Age-related Macular Degeneration: A Multicenter Study

Kim J, Lee SJ, Park TK, Sun HJ, Kim HD, Cho IH, Han JW, Choi KS

Purpose: To compare short-term efficacy and safety of intravitreal brolucizumab injection with aflibercept in treatment-naive neovascular age-related macular degeneration (nAMD) patients. Methods: A total of 59 eyes from 59 treatment-naive nAMD...
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Neuroprotective effects of hesperetin on H 2 O 2 -induced damage in neuroblastoma SH-SY5Y cells

Moon HR, Yun JM

BACKGROUND/OBJECTIVES: Oxidative stress is a fundamental neurodegenerative disease trigger that damages and decimates nerve cells. Neurodegenerative diseases are chronic central nervous system disorders that progress and result from neuronal degradation...
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Systemic autoinflammatory disorders

Jeong DC

Inflammation is a physiologic defense mechanism against an out-side attack. Usually, it resolves after the removal of noxious causes, but systemic autoinflammatory disorders (SAIDs) have recurrent or repeated acute inflammation...
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Effects of Pogonatherum paniceum (Lamk) Hack extract on antimitochondrial DNA mediated inflammation by attenuating Tlr9 expression in LPS-induced macrophages

Thongboontho R, Petcharat K, Munkong N, Khonthun C, Boondech A, Phromnoi K, Thim-uam A

BACKGROUND/OBJECTIVES: Mitochondrial DNA leakage leads to inflammatory responses via endosome activation. This study aims to evaluate whether the perennial grass water extract (Pogonatherum paniceum) ameliorate mitochondrial DNA (mtDNA) leakage. MATERIALS/METHODS: The...
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Microbiological links between periodontitis and systemic diseases: a brief review

Lee SW

Recent studies have suggested a strong association between chronic periodontitis and various chronic systemic diseases (condition), such as cardiovascular disease, diabetes, respiratory disease, adverse pregnancy outcomes, rheumatoid arthritis, certain types...
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Mechanistic Insight into Age-Related Macular Degeneration (AMD): Anatomy, Epidemiology, Genetics, Pathogenesis, Prevention, Implications, and Treatment Strategies to Pace AMD Management

Amini MA, Karbasi A, Vahabirad M, Khanaghaei M, Alizamir A

One of the most complicated eye disorders is age-related macular degeneration (AMD) which is the leading cause of irremediable blindness all over the world in the elderly. AMD is classified as...
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Association between periodontal diseases and bipolar disorder: implications for therapeutic interventions: A narrative review

Baek JH, Jung SJ, Peters A, Kantarci A, Nierenberg AA

Chronic low-grade inflammation plays a role in the pathophysiology of bipolar disorder. Recent studies have shown that periodontitis can affect the central nervous system by activating inflammatory mediators in the...
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C-Reactive Protein Signaling Pathways in Tumor Progression

Kim ES, Kim SY, Moon A

Many cancers arise from sites of chronic inflammation, which creates an inflammatory microenvironment surrounding the tumor. Inflammatory substances secreted by cells in the inflammatory environment can induce the proliferation and...
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Delta neutrophil index in obese and non-obese polycystic ovary syndrome patients

Günday , Yılmazer M

Objective We aimed to evaluate the usefulness of delta neutrophil index (DNI), a new inflammatory marker, in polycystic ovary syndrome (PCOS). Methods This retrospective case-control study was conducted at a tertiary...
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Omega-3 fatty acids upregulate Nrf2 expression and attenuate apoptosis, inflammation, and fibrosis in a rat model of cyclosporine-induced nephropathy

Lee JY, Son YK, Lee MH, Lee SM, Kim SE, An WS

Background: Cyclosporine A (CsA)-induced kidney injury is characterized by renal impairment with inflammatory cell infiltrations, apoptosis, fibrosis, and hypoxic injury. It is not clear whether omega-3 fatty acids (O-3 FAs),...
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