- Correlation of advanced glycation end products and heme oxygenase-1 in Korean diabetic patients
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Choi HN, Koo DH, Yim JE
- KMID: 2530890
- J Nutr Health.
- 2022 Jun;55(3):348-358.
- doi: 10.4163/jnh.2022.55.3.348
Purpose: Hyperglycemia accelerates the formation of advanced glycation end products (AGEs), a group of compounds formed via non-enzymatic glycation/glycoxidation. Type 2 diabetes mellitus (T2DM) is related to oxidative stress, resulting... -
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- Oxymatrine inhibits the pyroptosis in rat insulinoma cells by affecting nuclear factor kappa B and nuclear factor (erythroidderived 2)-like 2 protein/heme oxygenase-1 pathways
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Gao J, Xia L, Wei Y
- KMID: 2529399
- Korean J Physiol Pharmacol.
- 2022 May;26(3):165-174.
- doi: 10.4196/kjpp.2022.26.3.165
As the mechanism underlying glucose metabolism regulation by oxymatrine is unclear, this study investigated the effects of oxymatrine on pyroptosis in INS-1 cells. Flow cytometry was employed to examine cell... -
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- Non-canonical vs. Canonical Functions of Heme Oxygenase-1 in Cancer
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Jagadeesh ASV, Fang X, Kim SH, Guillen-Quispe YN, Zheng J, Surh YJ, Kim SJ
- KMID: 2528081
- J Cancer Prev.
- 2022 Mar;27(1):7-15.
- doi: 10.15430/JCP.2022.27.1.7
Heme oxygenase-1 (HO-1) is a critical stress-responsive enzyme that has antioxidant and anti-inflammatory functions. HO-1 catalyzes heme degradation, which gives rise to the formation of carbon monoxide (CO), biliverdin, and... -
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- Evaluation of superoxide dismutase 3, heme-oxygenase, and myeloperoxidase expression levels associated with oxidative stress in chronic periodontitis
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Yoon Y, Kim H, Lee JM
- KMID: 2521021
- Oral Biol Res.
- 2021 Sep;45(3):99-106.
- doi: 10.21851/obr.45.03.202109.99
This study aimed to investigate the expression levels of antioxidative enzymes such as superoxide dismutase 3 (SOD3), heme-oxygenase (HO), and myeloperoxidase (MPOs), which are known to be associated with oxidative... -
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- Bacillus clausii, a Foreshore-Derived Probiotic, Attenuates Allergic Airway Inflammation Through Downregulation of Hypoxia Signaling
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Park H, Jung AY, Chang CS, Kim YH
- KMID: 2508955
- J Rhinol.
- 2020 Nov;27(2):108-116.
- doi: 10.18787/jr.2020.00325
Background and Objectives: The immunomodulatory effects and mechanism of probiotics in allergic airway disease are largely unknown. We studied whether Bacillus clausii (BC), a probiotic derived from mudflats, had anti-allergic... -
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- Cereblon Deletion Ameliorates Lipopolysaccharide-induced Proinflammatory Cytokines through 5′-Adenosine Monophosphate-Activated Protein Kinase/Heme Oxygenase-1 Activation in ARPE-19 Cells
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Kim YK, Chae SC, Yang HJ, An DE, Lee S, Yeo MG, Lee KJ
- KMID: 2504720
- Immune Netw.
- 2020 Jun;20(3):e26.
- doi: 10.4110/in.2020.20.e26
Cereblon (CRBN), a negative modulator of AMP-activated protein kinase (AMPK), is highly expressed in the retina. We confirmed the expression of CRBN in ARPE-19 human retinal cells by Western blotting.... -
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- 17β-Estradiol reduces inflammation and modulates antioxidant enzymes in colonic epithelial cells
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Son HJ, Kim N, Song CH, Lee SM, Lee HN, Surh YJ
- KMID: 2502017
- Korean J Intern Med.
- 2020 Mar;35(2):310-319.
- doi: 10.3904/kjim.2018.098
Background/Aims: Estrogen is known to have protective effect in colorectal cancer development. The aims of this study are to investigate whether estradiol treatment reduces inflammation in CCD841CoN, a female human... -
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- Platycarya strobilacea leaf extract protects mice brain with focal cerebral ischemia by antioxidative property
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Lee JH, Jeong JH, Jeong YG, Kim DK, Lee NS, Na CS, Doh ES, Han SY
- KMID: 2466703
- Anat Cell Biol.
- 2019 Dec;52(4):486-497.
- doi: 10.5115/acb.19.141
The leaf extract of Platycarya strobilacea (PSL) has long been recognized as possessing various health-promoting activities. However, information on its possible protective effects against ischemic stroke is currently lacking. Here,... -
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- Nrf2-Heme oxygenase-1 modulates autophagy and inhibits apoptosis triggered by elevated glucose levels in renal tubule cells
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Kim JH, Kim KM, Jeong JU, Shin JH, Shin JM, Bang KT
- KMID: 2457723
- Kidney Res Clin Pract.
- 2019 Sep;38(3):318-325.
- doi: 10.23876/j.krcp.18.0152
BACKGROUND: Autophagy is a highly balanced process in which lysosomes remove aged and damaged organelles and cellular proteins. Autophagy is essential to maintain homeostasis in the kidneys. METHODS: Using human renal... -
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- Effects of heme oxygenase-1 upregulation on isoproterenol-induced myocardial infarction
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Eltobshy S, Hussein AM, Elmileegy , Askar MH, Khater Y, Metias EF, Helal GM
- KMID: 2443608
- Korean J Physiol Pharmacol.
- 2019 May;23(3):203-217.
- doi: 10.4196/kjpp.2019.23.3.203
The present study was designed to examine the effect of heme oxygenase-1 (HO-1) induction by cobalt protoporphyrin (CoPP) on the cardiac functions and morphology, electrocardiogram (ECG) changes, myocardial antioxidants (superoxide... -
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- Neuroprotective mechanisms of dieckol against glutamate toxicity through reactive oxygen species scavenging and nuclear factor-like 2/heme oxygenase-1 pathway
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Cui Y, Amarsanaa , Lee JH, Rhim JK, Kwon JM, Kim SH, Park JM, Jung SC, Eun SY
- KMID: 2438086
- Korean J Physiol Pharmacol.
- 2019 Mar;23(2):121-130.
- doi: 10.4196/kjpp.2019.23.2.121
Glutamate toxicity-mediated mitochondrial dysfunction and neuronal cell death are involved in the pathogenesis of several neurodegenerative diseases as well as acute brain ischemia/stroke. In this study, we investigated the neuroprotective... -
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- Vitamin D Improves Intestinal Barrier Function in Cirrhosis Rats by Upregulating Heme Oxygenase-1 Expression
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Wang PF, Yao DH, Hu YY, Li Y
- KMID: 2442015
- Biomol Ther.
- 2019 Feb;27(2):222-230.
- doi: 10.4062/biomolther.2018.052
Intestinal barrier dysfunction always accompanies cirrhosis in patients with advanced liver disease and is an important contributor facilitating bacterial translocation (BT), which has been involved in the pathogenesis of cirrhosis... -
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- The Effect of ABO Blood Groups, Hemoglobinopathy, and Heme Oxygenase-1 Polymorphisms on Malaria Susceptibility and Severity
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Kuesap J, Na-Bangchang K
- KMID: 2412735
- Korean J Parasitol.
- 2018 Apr;56(2):167-173.
- doi: 10.3347/kjp.2018.56.2.167
Malaria is one of the most important public health problems in tropical areas on the globe. Several factors are associated with susceptibility to malaria and disease severity, including innate immunity... -
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- Role of Carbon Monoxide in Neurovascular Repair Processing
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Choi YK
- KMID: 2429047
- Biomol Ther.
- 2018 Mar;26(2):93-100.
- doi: 10.4062/biomolther.2017.144
Carbon monoxide (CO) is a gaseous molecule produced from heme by heme oxygenase (HO). Endogenous CO production occurring at low concentrations is thought to have several useful biological roles. In... -
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- Effect of canine mesenchymal stromal cells overexpressing heme oxygenase-1 in spinal cord injury
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Lee SH, Kim Y, Rhew D, Kim A, Jo KR, Yoon Y, Choi KU, Jung T, Kim WH, Kweon OK
- KMID: 2412456
- J Vet Sci.
- 2017 Sep;18(3):377-386.
- doi: 10.4142/jvs.2017.18.3.377
Heme oxygenase-1 (HO-1) is a stress-responsive enzyme that modulates the immune response and oxidative stress associated with spinal cord injury (SCI). This study aimed to investigate neuronal regeneration via transplantation... -
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- Lithium ameliorates rat spinal cord injury by suppressing glycogen synthase kinase-3β and activating heme oxygenase-1
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Kim Y, Kim J, Ahn M, Shin T
- KMID: 2390482
- Anat Cell Biol.
- 2017 Sep;50(3):207-213.
- doi: 10.5115/acb.2017.50.3.207
Glycogen synthase kinase (GSK)-3β and related enzymes are associated with various forms of neuroinflammation, including spinal cord injury (SCI). Our aim was to evaluate whether lithium, a non-selective inhibitor of... -
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- Iron Contents in Rice Food Derived from the Iron Pot, and In Vitro Study Regarding Heme Oxygenase-1 Activity
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Kim KY, An YM, Kim TW, Jun YH, Lee JE, Jang JH, Kim SK
- KMID: 2358362
- Clin Pediatr Hematol Oncol.
- 2016 Oct;23(2):77-82.
- doi: 10.15264/cpho.2016.23.2.77
BACKGROUND: Iron pots have long been used for cooking in several countries. Early studies have shown that the use of such iron pots can increase the iron content of food... -
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- Fraxetin Induces Heme Oxygenase-1 Expression by Activation of Akt/Nrf2 or AMP-activated Protein Kinase α/Nrf2 Pathway in HaCaT Cells
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Kundu J, Chae IG, Chun KS
- KMID: 2367571
- J Cancer Prev.
- 2016 Sep;21(3):135-143.
- doi: 10.15430/JCP.2016.21.3.135
BACKGROUND: Fraxetin (7,8-dihydroxy-6-methoxy coumarin), a coumarin derivative, has been reported to possess antioxidative, anti-inflammatory and neuroprotective effects. A number of recent observations suggest that the induction of heme oxygenase-1 (HO-1)... -
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- Isoegomaketone Upregulates Heme Oxygenase-1 in RAW264.7 Cells via ROS/p38 MAPK/Nrf2 Pathway
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Jin CH, So YK, Han SN, Kim JB
- KMID: 2351675
- Biomol Ther.
- 2016 Sep;24(5):510-516.
- doi: 10.4062/biomolther.2015.194
Isoegomaketone (IK) was isolated from Perilla frutescens, which has been widely used as a food in Asian cuisine, and evaluated for its biological activity. We have already confirmed that IK... -
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- The Anti-Inflammatory Activity of Eucommia ulmoides Oliv. Bark. Involves NF-κB Suppression and Nrf2-Dependent HO-1 Induction in BV-2 Microglial Cells
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Kwon SH, Ma SX, Hwang JY, Ko YH, Seo JY, Lee BR, Lee SY, Jang CG
- KMID: 2164219
- Biomol Ther.
- 2016 May;24(3):268-282.
- doi: 10.4062/biomolther.2015.150
In the present study, we investigated the anti-inflammatory properties of Eucommia ulmoides Oliv. Bark. (EUE) in lipopolysaccharide (LPS)-stimulated microglial BV-2 cells and found that EUE inhibited LPS-mediated up-regulation of pro-inflammatory... -
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