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Polygenic Risk Score for Cardiovascular Diseases in Artificial Intelligence Paradigm: A Review

Khanna NN, Singh M, Maindarkar M, Kumar A, Johri AM, Mentella L, Laird JR, Paraskevas KI, Ruzsa Z, Singh N, Kalra MK, Fernandes JFE, Chaturvedi S, Nicolaides A, Rathore V, Singh I, Teji JS, Al-Maini M, Isenovic ER, Viswanathan V, Khanna P, Fouda MM, Saba L, Suri JS

Cardiovascular disease (CVD) related mortality and morbidity heavily strain society. The relationship between external risk factors and our genetics have not been well established. It is widely acknowledged that environmental influence...
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Differences in Leukocyte Transcriptomes of Morbidly Obese Patients With High Output Heart Failure: A Pilot Study

Cintron SA, Pierce J, Sardiu ME, Mahoney D, Peltzer J, Gupta B, Shen Q

Background and Objectives: Heart failure is characterized by alterations of gene expression that provide insight into the underlying pathophysiologic mechanisms. However, obesity-related high output heart failure (HOHF) is a specific...
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Clinicopathological Characteristics of NRG1 Fusion–Positive Solid Tumors in Korean Patients

Cha YJ, Lee C, Joo B, Kim KA, Lee Ck, Shim HS

Purpose Neuregulin 1 (NRG1) gene fusion is a potentially actionable oncogenic driver. The oncoprotein binds to ERBB3-ERBB2 heterodimers and activates downstream signaling, supporting a therapeutic approach for inhibiting ERBB3/ERBB2. However,...
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A streamlined pipeline based on HmmUFOtu for microbial community profiling using 16S rRNA amplicon sequencing

Kim H, Kim J, Choi JW, Ahn KS, Park DI, Kim S

Microbial community profiling using 16S rRNA amplicon sequencing allows for taxonomic characterization of diverse microorganisms. While amplicon sequence variant (ASV) methods are increasingly favored for their fine-grained resolution of sequence...
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Brain Invasion and Trends in Molecular Research on Meningioma

Go KO, Kim YZ

Meningiomas are the most common primary brain tumors in adults. The treatment of non-benign meningiomas remains a challenging task, and after the publication of the 2021 World Health Organization classification,...
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Antimicrobial resistance in Klebsiella pneumoniae: identification of bacterial DNA adenine methyltransferase as a novel drug target from hypothetical proteins using subtractive genomics

Omeershffudin UNM, Kumar S

Klebsiella pneumoniae is a gram-negative bacterium that is known for causing infection innosocomial settings. As reported by the World Health Organization, carbapenem-resistantEnterobacteriaceae, a category that includes K. pneumoniae, are classified...
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Predicting the Response of Neoadjuvant Chemotherapy in Hormone Receptor-Positive, Human Epidermal Growth Factor Receptor 2-Negative Breast Cancer With Axillary Lymph Node Metastasis by Multigene Assay

Lee JH, Ryu JM, Ahn JH, Cho SY, Lee SK, Yu J, Chae BJ, Nam SJ, Han J, Lee JE, Kim SW

Purpose: The GenesWell™ breast cancer test (BCT) is a recently developed multigene assay that predicts the risk of distant recurrence in patients with hormone receptor-positive (HR+) and human epidermal growth...
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Molecular analyses of peritoneal metastasis from colorectal cancer

Kim CH

Background: Despite a trend showing continued improvement in survival by combing targeted agents for colorectal cancer (CRC), the improvement observed is limited. Moreover, clinically relevant benefits were not achieved in...
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Genomic Profiling of Prostate Cancer: An Updated Review

Hatano K, Nonomura N

Understanding the genomic profiling of prostate cancer is crucial, owing to the emergence of precision medicine to guide therapeutic approaches. Over the last decade, integrative genomic profiling of prostate tumors...
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Genetic Odyssey to Ossification of the Posterior Longitudinal Ligament in the Cervical Spine: A Systematic Review

Won YI, Lee CH, Yuh WT, Kwon SW, Kim CH, Chung CK

Despite numerous studies, the pathogenesis of ossification of the posterior longitudinal ligament (OPLL) is still unclear. Previous genetic studies proposed variations in genes related to bone and collagen as a...
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Genetic variations affecting response of radiotherapy

Choi EK

Radiation therapy (RT) is a very important treatment for cancer that irradiates a large amount of radiation to lead cancer cells and tissues to death. The progression of RT in...
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Recent Molecular and Genetic Findings in Intramedullary Spinal Cord Tumors

Nagashima Y, Nishimura Y, Eguchi K, Yamaguchi J, Haimoto S, Ohka F, Takayasu M, Saito R

The study of genetic alterations and molecular biology in central nervous system (CNS) tumors has improved the accuracy of estimations of patient prognosis and tumor categorization. Therefore, the updated 2021...
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Artificial Intelligence in Neuro-Oncologic Imaging: A Brief Review for Clinical Use Cases and Future Perspectives

Park JE

The artificial intelligence (AI) techniques, both deep learning end-to-end approaches and radiomics with machine learning, have been developed for various imaging-based tasks in neuro-oncology. In this brief review, use cases...
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Clinical Trials of Probiotics in Patients With Irritable Bowel Syndrome: Some Points to Consider

Quigley EMM

Probiotic products in various formulations are widely used world-wide for a seemingly limitless range of indications––from health maintenance to the alleviation of common intestinal ailments and on to the prevention...
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Oxidative Stress: A Comprehensive Review of Biochemical, Molecular, and Genetic Aspects in the Pathogenesis and Management of Varicocele

Finelli R, Leisegang K, Kandil H, Agarwal A

Oxidative stress is a condition due to an imbalance between the concentrations of oxidants and antioxidants, and it is a wellrecognized contributor in several male infertility conditions. Varicocele, a common...
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Medical genomic approach to early-onset scoliosis

Yim SY

Early onset scoliosis (EOS) describes the onset of scoliosis before the age of 10 years and is associated with significant health risks. Compared to adolescent idiopathic scoliosis, studies on the...
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Machine Learning and Deep Learning for the Pharmacogenomics of Antidepressant Treatments

Lin E, Lin CH, Lane HY

A growing body of evidence now proposes that machine learning and deep learning techniques can serve as a vital foundation for the pharmacogenomics of antidepressant treatments in patients with major...
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Role of Genetics in Preventive Cardiology: Focused on Dyslipidemia

Lee SH

Dyslipidemia is a strong risk factor for cardiovascular disease as well as a major target for its prevention. Along with the progress in genetic research techniques and bioinformatics analysis, genetic...
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Diagnostic Classification and Genomic Analyses of Cancer

Kim JW

Diagnostic classification of diseases is fundamental to disease diagnosis and treatment. Cancers have traditionally been classified based on histopathology, but cancer is defined as a genetic disease. Emerging genetic knowledge...
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Understanding Obesity-Related High Output Heart Failure and Its Implications

Shen Q, Hiebert JB, Rahman FK, Krueger KJ, Gupta B, Pierce JD

Morbid obesity remains most common cause of high output failure. The prevalence of the obesity is growing when two-thirds of American adults already are overweight or obese. Obesity is the risk...
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