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Genomic Profiling of Prostate Cancer: An Updated Review

Hatano K, Nonomura N

Understanding the genomic profiling of prostate cancer is crucial, owing to the emergence of precision medicine to guide therapeutic approaches. Over the last decade, integrative genomic profiling of prostate tumors...
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Genetic Odyssey to Ossification of the Posterior Longitudinal Ligament in the Cervical Spine: A Systematic Review

Won YI, Lee CH, Yuh WT, Kwon SW, Kim CH, Chung CK

Despite numerous studies, the pathogenesis of ossification of the posterior longitudinal ligament (OPLL) is still unclear. Previous genetic studies proposed variations in genes related to bone and collagen as a...
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Genetic variations affecting response of radiotherapy

Choi EK

Radiation therapy (RT) is a very important treatment for cancer that irradiates a large amount of radiation to lead cancer cells and tissues to death. The progression of RT in...
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Recent Molecular and Genetic Findings in Intramedullary Spinal Cord Tumors

Nagashima Y, Nishimura Y, Eguchi K, Yamaguchi J, Haimoto S, Ohka F, Takayasu M, Saito R

The study of genetic alterations and molecular biology in central nervous system (CNS) tumors has improved the accuracy of estimations of patient prognosis and tumor categorization. Therefore, the updated 2021...
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Artificial Intelligence in Neuro-Oncologic Imaging: A Brief Review for Clinical Use Cases and Future Perspectives

Park JE

The artificial intelligence (AI) techniques, both deep learning end-to-end approaches and radiomics with machine learning, have been developed for various imaging-based tasks in neuro-oncology. In this brief review, use cases...
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Clinical Trials of Probiotics in Patients With Irritable Bowel Syndrome: Some Points to Consider

Quigley EMM

Probiotic products in various formulations are widely used world-wide for a seemingly limitless range of indications––from health maintenance to the alleviation of common intestinal ailments and on to the prevention...
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Oxidative Stress: A Comprehensive Review of Biochemical, Molecular, and Genetic Aspects in the Pathogenesis and Management of Varicocele

Finelli R, Leisegang K, Kandil H, Agarwal A

Oxidative stress is a condition due to an imbalance between the concentrations of oxidants and antioxidants, and it is a wellrecognized contributor in several male infertility conditions. Varicocele, a common...
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Medical genomic approach to early-onset scoliosis

Yim SY

Early onset scoliosis (EOS) describes the onset of scoliosis before the age of 10 years and is associated with significant health risks. Compared to adolescent idiopathic scoliosis, studies on the...
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Machine Learning and Deep Learning for the Pharmacogenomics of Antidepressant Treatments

Lin E, Lin CH, Lane HY

A growing body of evidence now proposes that machine learning and deep learning techniques can serve as a vital foundation for the pharmacogenomics of antidepressant treatments in patients with major...
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Role of Genetics in Preventive Cardiology: Focused on Dyslipidemia

Lee SH

Dyslipidemia is a strong risk factor for cardiovascular disease as well as a major target for its prevention. Along with the progress in genetic research techniques and bioinformatics analysis, genetic...
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Diagnostic Classification and Genomic Analyses of Cancer

Kim JW

Diagnostic classification of diseases is fundamental to disease diagnosis and treatment. Cancers have traditionally been classified based on histopathology, but cancer is defined as a genetic disease. Emerging genetic knowledge...
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Understanding Obesity-Related High Output Heart Failure and Its Implications

Shen Q, Hiebert JB, Rahman FK, Krueger KJ, Gupta B, Pierce JD

Morbid obesity remains most common cause of high output failure. The prevalence of the obesity is growing when two-thirds of American adults already are overweight or obese. Obesity is the risk...
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OMICS approaches in cardiovascular diseases: a mini review

Sohag MMH, Raqib SM, Akhmad SA

Ranked in the topmost position among the deadliest diseases in the world, cardiovascular diseases (CVDs) are a global burden with alterations in heart and blood vessels. Early diagnostics and prognostics...
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Genomics of diffuse large B cell lymphoma

Koh Y

Next generation sequencing (NGS) technology has revealed the heterogeneity of diffuse large B-cell lymphoma (DLBCL) from a mutation perspective. Accordingly, the conventional cell of origin-based classification of DLBCL has changed...
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Clinical Application of Targeted Deep Sequencing in Metastatic Colorectal Cancer Patients: Actionable Genomic Alteration in K-MASTER Project

Lee Y, Lee S, Sung JS, Chung HJ, Lim Ar, Kim JW, Choi YJ, Park KH, Kim YH

Purpose Next-generation sequencing (NGS) can facilitate precision medicine approaches in metastatic colorectal cancer (mCRC) patients. We investigated the molecular profiling of Korean mCRC patients under the K-MASTER project which was initiated...
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Mechanisms of TERT Reactivation and Its Interaction with BRAFV600E

Song YS, Park YJ

The telomerase reverse transcriptase (TERT) gene, which is repressed in most differentiated human cells, can be reactivated by somatic TERT alterations and epigenetic modulations. Moreover, the recruitment, accessibility, and binding...
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Effect of ethnicity on the prevalence of allergic disease

Kim HS, Kim HH

Differences in the prevalence and severity of allergic diseases exist among racial and ethnic groups. However, influence of population admixing on allergic disease has not been studied. This review aimed...
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Clinical Implication of Concordant or Discordant Genomic Profiling between Primary and Matched Metastatic Tissues in Patients with Colorectal Cancer

Choi JY, Choi S, Lee M, Park YS, Sung JS, Chang WJ, Kim JW, Choi YJ, Kim J, Kim DS, Lee SH, Seok J, Park KH, Kim SH, Kim YH

Purpose The purpose of this study was to identify the concordant or discordant genomic profiling between primary and matched metastatic tumors in patients with colorectal cancer (CRC) and to explore the...
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The Assessment of Bacterial and Fungal Biodiversity in Korean Dermatomycoses Patients: A Pilot Study

Chung BY, Seo JM, Kang MJ, Lee M, Shin J, Chung YJ, Yu DS, Lee YB

Background: Dermatophytes are the most common cause of fungal infections worldwide, having an estimated prevalence of 20% by the World Health Organization. Recent advances of sequencing and annotation of fungi...
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Radiogenomics Based on PET Imaging

Park YJ, Shin MH, Moon SH

Radiogenomics or imaging genomics is a novel omics strategy of associating imaging data with genetic information, which has the potential to advance personalized medicine. Imaging features extracted from PET or...
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