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Consideration for Coronavirus Disease 2019 Drug Treatment in Patients with Epilepsy on Antiepileptic Drugs

Byun JI, Sunwoo JS, Kang KW, Kim KT, Kim D, Kim DW, Kim S, Kim SH, Kim W, Moon HJ, Park HR, Seo JG, Chu MK, Hwang KJ, Seo DW,

Several medications are approved to treat coronavirus disease 2019 (COVID-19) in Korea including nirmatrelvir/ritonavir, remdesivir, and regdanvimab. There is potential drug-drug interaction between antiepileptic drugs (AEDs) and the medications used...
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Effects of Vagus Nerve Stimulation on Sleep-Disordered Breathing, Daytime Sleepiness, and Sleep Quality in Patients With Drug-Resistant Epilepsy

Kim JS, Lee DE, Bae H, Song JY, Yang KI, Hong SB

Background and Purpose This study aimed to determine the long-term effects of vagus nerve stimulation (VNS) on sleep-disordered breathing (SDB), daytime sleepiness, and sleep quality in patients with drug-resistant epilepsy...
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Long-Term Management of Seizures after Surgical Treatment of Supratentorial Cavernous Malformations : A Retrospective Single Centre Study

Dziedzic TA, Koczyk K, Nowak A, Maj E, Marchel A

Objective : Seizure recurrence after the first-ever seizure in patients with a supratentorial cerebral cavernous malformation (CCM) is almost certain, so the diagnosis and treatment of epilepsy is justified. The...
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Trends in Prescribing of Antiseizure Medications in South Korea: Real-World Evidence for Treated Patients With Epilepsy

Kang KW, Lee H, Shin JY, Moon HJ, Lee SY

Background and Purpose We investigated the trends in the prescribing of antiseizure medication (ASM) over a 9-year period, and provide real-world data regarding ASM prescriptions of patients with epilepsy in...
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Efficacy of the Ketogenic Diet for Pediatric Epilepsy According to the Presence of Detectable Somatic mTOR Pathway Mutations in the Brain

Ko A, Sim NS, Choi HS, Yang D, Kim SH, Lee JS, Kim DS, Lee JH, Kim HD, Kang HC

Background and Purpose A multifactorial antiepileptic mechanism underlies the ketogenic diet (KD), and one of the proposed mechanisms of action is that the KD inhibits the mammalian target of rapamycin...
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Effective ketogenic diet in CACNA1A-related ‘epilepsy of infancy with migrating focal seizures’

Na H, Lee S, Kim YO

Genetic causes of developmental and epileptic encephalopathy (DEE) have been rapidly uncovered from mid-2010s. The mutations of gene enconding calcium channel, voltage-dependent, P/Q type, alpha 1A subunit (CACNA1A) are recently...
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Two Focal Seizure in a Patient Caused by Different Mechanism

Kim HJ, Ryu HU, Shin BS, Kang HG

Poststroke epilepsy is the most common cause of epilepsy in adult. Acute symptomatic seizure is a provoked seizure usually caused by systemic metabolic disorders. If stroke patient has a seizure,...
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Practical Drug Treatment Recommendations on the Drug Refractory Epilepsy Patients: 2021 Clinical Guideline Subcommittee for Epilepsy in the Korean Neurological Association

Shin DJ, Shon YM, Jung KY, Koo YS, Kim D, Seo JG, Kim J, Song HK

One third of the overall epilepsy population are estimated to be a drug refractory epilepsy (DRE), defined as the patients who failed to control seizure reduction, even tried two or...
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Is it really a seizure? The challenge of paroxysmal nonepileptic events in young infants

Jung SY, Kang JW

Paroxysmal nonepileptic events (PNE) comprise of a variety of nonepileptic behaviors and are divided into various types. A more accurate diagnosis is possible by examining the video clip provided by...
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Increasing Trends in the Incidence and Prevalence of Epilepsy in Korea

Jeon JY, Lee H, Shin JY, Moon HJ, Lee SY, Kim JM, on behalf of Epidemiology Committee of Korean Epilepsy Society

Background and Purpose There have been few reports on recent trends in the occurrence of epilepsy. The aim of this study was to estimate the incidence and prevalence of epilepsy...
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Effect of Long-Term Treatment with Vagus Nerve Stimulation on Mood and Quality of Life in Korean Patients with Drug-Resistant Epilepsy

Kim JS, Kim DY, Jo HJ, Hwang YH, Song JY, Yang KI, Hong SB

Background and Purpose This study aimed to determine the long-term effects of vagus nerve stimulation (VNS) treatment on suicidality, mood-related symptoms, and quality of life (QOL) in patients with drug-resistant...
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Gamma-Knife Radiosurgery for Hypothalamic Hamartoma-Related Epilepsy

Song JY, Lee JI, Shin HJ, Lee J, Lee J

Purpose: Hypothalamic hamartoma (HH), a rare congenital disorder, can cause intractable epilepsy and requires optimal surgical treatment. This study analyzed the clinical characteristics of HH and evaluated seizure outcomes and...
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Concept Analysis of Parents’ Treatment Adherence for an Epileptic Child or Adolescent

Lee J, Yoon JY

Purpose: This concept analysis was conducted to clarify ‘parents’ treatment adherence for an epileptic child or adolescent’. Methods: The analysis used a hybrid model comprising three phases: theoretical phase, fieldwork...
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Treatment strategies targeting specific genetic etiologies in epilepsy

Kim HJ, Kang HC

Recent genetic advances allow for identification of the genetic etiologies of epilepsy within individual patients earlier and more frequently than ever. Specific targeted treatments have emerged from improvements in understanding...
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Current Pharmacologic Strategies for Treatment of Intractable Epilepsy in Children

Moon JU, Cho KO

Epileptic encephalopathy (EE) is a devastating pediatric disease that features medically resistant seizures, which can contribute to global developmental delays. Despite technological advancements in genetics, the neurobiological mechanisms of EEs...
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Psychoses of Epilepsy in Pregnancy: A Case Report

Fahed M, Ramanathan S

To discuss the unique relationship between psychosis and seizures in a young individual, who is also pregnant. Psychosis of epilepsy can present in multitude of ways, including pre-ictal, ictal, post-ictal,...
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Tectal glioma presenting with adult-onset epileptic seizures

Kim JH, Jo H, Choi JW, Joo EY

Tectal glioma is an indolent and benign tumor that occurs predominantly in the pediatric population. It arises in the tectum of the midbrain and, due to its location, contributes to...
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Ketamine-induced generalized convulsive seizure during procedural sedation

Kim JH, Lee CK, Yu SH, Min BD, Chung CE, Kim DC

Ketamine is used widely in emergency departments for a variety of purposes, including procedural sedation for facial laceration in pediatric patients. The major benefits are its rapid onset of effects,...
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Systematic Literature Review of Psychiatric Comorbidities in Adults with Epilepsy

Lu E, Pyatka N, Burant CJ, Sajatovic M

Background and Purpose Mental illness is disproportionately common in people with epilepsy (PWE). This systematic literature review identified original research articles that reported the prevalence of psychiatric comorbidities based upon...
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Clinical and Genetic Spectrum of STXBP1 Encephalopathy in the Korean Pediatric Population

Kim WJ, Shim YK, Ko YJ, Kim SY, Kim H, Lim BC, Hwang H, Choi J, Kim KJ, Chae JH

Purpose: Syntaxin-binding protein 1 (STXBP1) mutations are known to result in various phenotypes including Ohtahara syndrome, West syndrome, and autism, collectively referred as STXBP1 encephalopathy. This study aimed to expand...
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