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Adverse Drug Reactions to Dapsone: A Retrospective Study during the Last 15 Years

Park YJ, Shin HY, Choi WK, Hong JS, Lee SH, Lee AY

  • KMID: 2544979
  • Korean J Dermatol.
  • 2023 Jul;61(6):331-341.
Background: Dapsone has been used for a long time to treat skin diseases. Although various drug-related side effects and adverse reactions to dapsone have been reported, most studies have addressed...
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Advances in management of pediatric chronic immune thrombocytopenia: a narrative review

Lee JM

Immune thrombocytopenia (ITP) is a disease in which thrombocytopenia occurs because of immune-mediated platelet destruction and decreased platelet production. Although many pediatric patients with ITP experience spontaneous remission or reach...
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Treatment of refractory IgA vasculitis with dapsone: a systematic review

Lee KH, Hong SH, Jun J, Jo Y, Jo W, Choi D, Joo J, Jung G, Ahn S, Kronbichler A, Eisenhut M, Shin JI

IgA vasculitis, formerly known as Henoch-Schönlein purpura, is a systemic IgA-mediated vasculitis of the small vessels commonly seen in children. The natural history of IgA vasculitis is generally self-limiting; however,...
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Dapsone modulates lipopolysaccharide-activated bone marrow cells by inducing cell death and down-regulating tumor necrosis factor-α production

Kwon MJ, Joo HG

Dapsone, an antibiotic, has been used to cure leprosy. It has been reported that dapsone has anti-inflammatory activity in hosts; however, the anti-inflammatory mechanism of dapsone has not been fully...
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A Case of Palisaded Neutrophilic and Granulomatous Dermatitis Treated with Dapsone

Kim YW, You M, Kim J, Shin DH, Choi JS

  • KMID: 2436887
  • Korean J Dermatol.
  • 2018 Sep;56(8):513-514.
No abstract available.
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A Case of Steroid-resistant Neutrophilic Dermatosis of the Hands Treated with Dapsone

Oh EH, Cheon DU, Ko JY, Ro YS, Kim JE

  • KMID: 2388341
  • Korean J Dermatol.
  • 2017 Jul;55(6):374-376.
No abstract available.
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Dapsone therapy for refractory immune thrombocytopenia patients: a case series

Lee JY, Lee JO, Jung JY, Bang SM

BACKGROUND: Dapsone has been recommended as a second-line immunosuppressive agent for patients with immune thrombocytopenia (ITP). METHODS: We retrospectively analyzed the efficacy and safety of dapsone therapy in patients with ITP. RESULTS:...
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Clinical application of dapsone in two cases of canine sterile nodular panniculitis

Kim SH, Cho SH, Kang JH, Yang MP, Mo IP, Kang BT

This report describes the different responses to dapsone treatment in two cases of sterile nodular panniculitis (SNP). Two dogs were presented with ulcerative skin lesions, painful and erythematous papules, and...
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A Case of Diabetic Ketoacidosis Caused by Dapsone-Induced Acute Pancreatitis

Seo JB, Shin KH, Kim MJ, Park JE, Park KK, Kim JG, Lee IK, Kim SW

Drug-induced pancreatitis accounts for 0.1~2.0% of all pancreatitis cases. Generally, the mechanism of drug-induced pancreatitis is an immune reaction, accumulation of toxic material, and/or ischemia. However, how dapsone causes pancreatitis...
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Clinical outcomes of adverse cardiovascular events in patients with acute dapsone poisoning

Kang KS, Kim HI, Kim OH, Cha KC, Kim H, Lee KH, Hwang SO, Cha YS

OBJECTIVE: Adverse cardiovascular events (ACVEs) account for a large proportion of the morbidities and mortalities associated with drug overdose emergencies. However, there are no published reports regarding outcomes of ACVEs...
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Anti-inflammatory effects of 4,4'-diaminodiphenyl sulfone (dapsone) in lipopolysaccharide-treated spleen cells: selective inhibition of inflammation-related cytokines

Moon SY, Joo HG

4,4'-diaminodiphenyl sulfone (dapsone) is a sulfone drug that has antibacterial effects on a variety of bacteria, especially Mycobacterium leprae; thus, it has been used to treat leprosy. Previous studies demonstrated...
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Dapsone Hypersensitivity Syndrome with EBV Reactivation

Cho JW, Lee KS, Han G

  • KMID: 1796732
  • Korean J Dermatol.
  • 2014 May;52(5):358-360.
No abstract available.
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High-dose Vitamin C therapy in Methemoglobinemia

Lee KW, Kang TS, Park SY

  • KMID: 2333826
  • J Korean Soc Emerg Med.
  • 2014 Apr;25(2):202-205.
Methylene blue is the first choice antidote for management of methemoglobinemia, however, some patients are refractory to methylene blue and in most cases, methylene blue cannot be available instantly in...
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Dapsone-induced drug reaction with eosinophilia and systemic symptoms syndrome, misdiagnosed as lymphoma

Shin B, Park SY, Yoon SY, Shin EH, Yang YJ, Cho HJ, Jang IY, Kang DU, Kim TB, Cho YS, Moon HB, Kwon HS

Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a life-threatening adverse drug reaction with systemic manifestations. Dapsone is known to be useful for treatment of leprosy and various...
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Severe dapsone hypersensitivity syndrome in a child

Choi SY, Hwang HY, Lee JH, Park JS, Jang MS

  • KMID: 2353172
  • Korean J Pediatr.
  • 2013 Jun;56(6):260-264.
Dapsone (4,4'-diaminodiphenylsulfone, DDS), a potent anti-inflammatory agent, is widely used in the treatment of leprosy and several chronic inflammatory skin diseases. Dapsone therapy rarely results in development of dapsone hypersensitivity...
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Subcorneal pustular dermatosis in a dog

Park SJ

  • KMID: 1991781
  • Korean J Vet Res.
  • 2013 Jun;53(2):125-127.
Canine Subcorneal pustular dermatosis (CSPD) represents a sterile, superficial, pustular skin disease of unknown cause but may be a variant of pemphigus foliaceus. A 7-year-old, intact female, mixed dog presented...
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Cervical Lymphadenopathy Mimicking Angioimmunoblastic T-Cell Lymphoma after Dapsone-Induced Hypersensitivity Syndrome

Rim MY, Hong J, Yo I, Park H, Chung DH, Ahn JY, Park S, Park J, Kim YS, Lee JH

  • KMID: 2012068
  • Korean J Pathol.
  • 2012 Dec;46(6):606-610.
A 36-year-old woman presented with erythematous confluent macules on her whole body with fever and chills associated with jaundice after 8 months of dapsone therapy. Her symptoms had developed progressively,...
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Erythema Elevatum Diutinum in Human Immunodeficiency Virus Infected Patient

Kim JM, Song SH, Park Y, Eom M, Kim HS, Choi EH, Choi HK, Kim HY, Kim YK

Erythema elevatum diutinum (EED) is emerging as a specific HIV-associated dermatosis which can be easily misdiagnosed as Kaposi's sarcoma or bacillary angiomatosis. Until now, no case of HIV-associated EED had...
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Drug Hypersensitivity Syndrome Associated Dapsone

Kim JG, Kim CY

  • KMID: 2247465
  • Korean J Dermatol.
  • 2012 May;50(5):475-476.
No abstract available.
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The Neumann Type of Pemphigus Vegetans Treated with Combination of Dapsone and Steroid

Son YM, Kang HK, Yun JH, Roh JY, Lee JR

Pemphigus vegetans is a rare variant of pemphigus vulgaris and is characterized by vegetating lesions in the inguinal folds and mouth and by the presence of autoantibodies against desmoglein 3....
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