- Efficacy of Ulinastatin and Sulforaphane Alone or in Combination in Rat Model of Streptozotocin Diabetes Induced Vascular Dementia
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Sharma P, Kaushik P, Jain S, Sharma BM, Awasthi R, Kulkarni GT, Sharma B
- KMID: 2519555
- Clin Psychopharmacol Neurosci.
- 2021 Aug;19(3):470-489.
- doi: 10.9758/cpn.2021.19.3.470
Objective: Vascular Dementia (VaD), is associated with metabolic conditions. Diabetes is a major risk factor for the development of VaD. This study investigates the efficacy of ulinastatin (UTI) and sulforaphane... -
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- Butyrylcholinesterase Inhibitory Activity and GC-MS Analysis of Carica papaya Leaves
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Khaw KY, Yeou Chear NJ, Maran S, Yeong KY, Ong YS, Goh BH
- KMID: 2507474
- Nat Prod Sci.
- 2020 Jun;26(2):165-170.
- doi: 10.20307/nps.2020.26.2.165
Carica papaya is a medicinal and fruit plant owing biological activities including antioxidant, antiviral, antibacterial and anticancer. The present study aims to investigate the acetyl (AChE) and butyryl (BChE) cholinesterase... -
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- Clinical characteristics and cholinesterase levels in childrenwith carbofuran poisoning
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Yoon SA, Woo SI
- KMID: 2500272
- J Korean Soc Emerg Med.
- 2020 Apr;31(2):228-235.
Objective: Acute group poisoning caused by food ingestion occurred in an elementary school in Korea. We aimed to describe the clinical characteristics, emergency treatment, outcomes, and the cholinesterase level of children... -
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- Pyridostigmine in Pediatric Intestinal Pseudo-obstruction: Case Report of a 2-year Old Girl and Literature Review
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Di Nardo G, Viscogliosi F, Esposito F, Stanghellini V, Villa MP, Parisi P, Morlando A, Calò G, De Giorgio R
- KMID: 2460479
- J Neurogastroenterol Motil.
- 2019 Oct;25(4):508-514.
- doi: 10.5056/jnm19078
Pediatric chronic intestinal pseudo-obstruction is a rare disorder characterized by a severe impairment of gastrointestinal motility leading to intestinal obstruction symptoms in the absence of mechanical causes. The diagnosis is... -
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- Chemical Constituents from Solenostemma argel and their Cholinesterase Inhibitory Activity
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Demmak RG, Bordage S, Bensegueni A, Boutaghane N, Hennebelle T, Mokrani EH, Sahpaz S
- KMID: 2452780
- Nat Prod Sci.
- 2019 Jun;25(2):115-121.
- doi: 10.20307/nps.2019.25.2.115
Alzheimer's disease is a chronic neurodegenerative disorder with no curative treatment. The commercially available drugs, which target acetylcholinesterase, are not satisfactory. The aim of this study was to investigate the... -
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- Isolation of Flavonoid Glycosides with Cholinesterase Inhibition Activity and Quantification from Stachys japonica
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Nugroho A, Choi JS, Seong SH, Song BM, Park KS, Park HJ
- KMID: 2432421
- Nat Prod Sci.
- 2018 Dec;24(4):259-265.
- doi: 10.20307/nps.2018.24.4.259
The three flavone glycosides, 4′-O-methylisoscutellarein 7-O-(6‴-O-acetyl)-β-D-allopyranosyl(1→2)-β-D-glucopyranoside (1), isoscutellarein 7-O-(6‴-O-acetyl)-β-D-allopyranosyl(1→2)-β-D-glucopyranoside (3), and isoscutellarein 7-O-β-D-allopyranosyl(1→2)-β-D-glucopyranoside (4) in addition to a flavonol glycoside, kaempferol 3-O-β-D-glucopyranoside (astragalin, 2), were isolated from Stachys japonica (Lamiaceae).... -
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- Pharmacotherapy for dementia
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Youn H, Jeong HG
- KMID: 2429340
- J Korean Med Assoc.
- 2018 Dec;61(12):758-764.
- doi: 10.5124/jkma.2018.61.12.758
Dementia is a clinical syndrome characterized by a cluster of symptoms and signs that manifest as difficulties in cognitive functions such as memory, psychological and psychiatric changes, and impairments in... -
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- Relative Risk and Clinical Severity Assessment in Patients with Non-Oral Route Organophosphate Poisoning Compared with Oral Route Poisoning
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Jung WJ, Yu MH, Lee Y, Kim H, Cha YS, Park KH
- KMID: 2419733
- Yonsei Med J.
- 2018 Oct;59(8):982-988.
- doi: 10.3349/ymj.2018.59.8.982
PURPOSE: Organophosphates, commonly used in agricultural pesticides, pose high risks and incidences of poisoning. In the present study, we investigated the relative risk and clinical severity, including laboratory results, of... -
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- Garcinexanthone G, a Selective Butyrylcholinesterase Inhibitor from the Stem Bark of Garcinia atroviridis
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Khaw KY, Murugaiyah V, Khairuddean M, Tan WN
- KMID: 2416067
- Nat Prod Sci.
- 2018 Jun;24(2):88-92.
- doi: 10.20307/nps.2018.24.2.88
The present study was undertaken to investigate the isolated compounds from the stem bark of Garcinia atroviridis as potential cholinesterase inhibitors and the ligand-enzyme interactions of selected bioactive compounds in... -
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- A survey of current concepts and practices related to use of neuromuscular blockers with antagonists and neuromuscular monitoring among Korean anesthesiologists
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Choi S, Jung M, Kim KM, Lee S, Yang HS, Lee JS
- KMID: 2436055
- Anesth Pain Med.
- 2018 Jan;13(1):47-52.
- doi: 10.17085/apm.2018.13.1.47
BACKGROUND: The goal of this nationwide survey was to investigate the current concepts and practices of the use of neuromuscular blockers and their antagonists, and the availability and clinical practice... -
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- A new 3, 4-epoxyfurocoumarin from Heracleum moellendorffii Roots
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Park SY, Lee N, Lee S, Kim MJ, Chun W, Kim HP, Yang HJ, Lee HS, Kwon Y
- KMID: 2393803
- Nat Prod Sci.
- 2017 Sep;23(3):213-216.
- doi: 10.20307/nps.2017.23.3.213
Activity-guided isolation of Heracleum moellendorffii roots led to four coumarin derivatives as acetylcholinesterase inhibitors. The structures of these isolates were characterized by spectroscopic method to be angelicin (1), isobergapten (2),... -
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- Improvement of Visuo-spatial Function Assessed by Raven’s Colored Progressive Matrices in Dementia with Lewy Bodies by Donepezil Treatment
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Yoshino Y, Mori T, Yoshida T, Toyota Y, Shimizu H, Iga JI, Nishitani , Ueno SI
- KMID: 2388270
- Clin Psychopharmacol Neurosci.
- 2017 Aug;15(3):243-247.
- doi: 10.9758/cpn.2017.15.3.243
OBJECTIVE: Donepezil is used to improve cognitive impairment of dementia with Lewy bodies (DLB). Visuo-spatial dysfunction is a well-known symptom of DLB. Non-verbal Raven’s Colored Progressive Matrices (RCPM) were used... -
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- Acetylcholinesterase Inhibitors from Angelica polymorpha Stem
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Kwon Y, Kim HP, Kim MJ, Chun W
- KMID: 2387058
- Nat Prod Sci.
- 2017 Jun;23(2):97-102.
- doi: 10.20307/nps.2017.23.2.97
Fourteen compounds were isolated from the stem of Angelica polymorpha. On the basis of spectral data, these compounds were identified as isoimperatorin (1), phellopterin (2), bergapten (3), xanthyletin (4), cnidilin... -
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- Pneumatosis Cystoides Intestinales and Portomesenteric Venous Gas following Anticholinesterase Pesticide Poisoning
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Lee SH, Lee KW, Jung JH
- KMID: 2386867
- J Korean Soc Clin Toxicol.
- 2017 Jun;15(1):56-59.
- doi: 10.22537/jksct.2017.15.1.56
Pneumatosis cystoides intestinalis and portomesenteric venous gas are uncommon radiological findings, but are found commonly in cases of bowel ischemia, or as a result of various non-ischemic conditions. A 72-year-old... -
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- Evaluation of Antioxidant, Anti-cholinesterase, and Anti-inflammatory Effects of Culinary Mushroom Pleurotus pulmonarius
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Nguyen TK, Im KH, Choi J, Shin PG, Lee TS
- KMID: 2366454
- Mycobiology.
- 2016 Dec;44(4):291-301.
- doi: 10.5941/MYCO.2016.44.4.291
Culinary mushroom Pleurotus pulmonarius has been popular in Asian countries. In this study, the anti-oxidant, cholinesterase, and inflammation inhibitory activities of methanol extract (ME) of fruiting bodies of P. pulmonarius... -
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- Clinical Significance of Repetitive Compound Muscle Action Potentials in Patients with Myasthenia Gravis: A Predictor for Cholinergic Side Effects of Acetylcholinesterase Inhibitors
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Lee HE, Kim YH, Kim SM, Shin HY
- KMID: 2385114
- J Clin Neurol.
- 2016 Oct;12(4):482-488.
- doi: 10.3988/jcn.2016.12.4.482
BACKGROUND AND PURPOSE: Acetylcholinesterase inhibitors (AChEIs) are widely used to treat myasthenia gravis (MG). Although AChEIs are usually tolerated well, some MG patients suffer from side effects. Furthermore, a small... -
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- Clinical Predictors for Mild Cognitive Impairment Progression in a Korean Cohort
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Shim YS, Yang DW, Yoon B, Lee Y, Hong CH, Seo SW, Yoon SJ, Jeong JH, Park MH, Choi SH, Kim SY
- KMID: 2442848
- Dement Neurocogn Disord.
- 2016 Sep;15(3):68-74.
- doi: 10.12779/dnd.2016.15.3.68
BACKGROUND AND PURPOSE: Patients with mild cognitive impairment (MCI) and their caregivers are concerned with the likelihood and time course of progression to dementia. This study was performed to identify... -
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- Recent Advances in Diagnosis and Treatment of Alzheimer's Disease
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Lee JJ, Lee SB
- KMID: 2165127
- Korean J Biol Psychiatry.
- 2016 May;23(2):48-56.
- doi: 10.0000/kjbp.2016.23.2.48
Alzheimer's disease (AD) is a neurodegenerative disorder in which neuronal loss causes cognitive decline and other neuropsychiatric problems. It can be diagnosed based on history, examination, and appropriate objective assessments,... -
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- Single Photon Emission Computerized Tomography and Neuropsychological Tests That Predict a Good Response to Donepezil Therapy for Alzheimer's Disease
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Kim DE, Chong A, Song HC, Choi SM, Kang KW, Ha JM, Kim JH, Kim TH, Jeong GW, Park KW, de Leon MJ, Kim BC
- KMID: 2442985
- Dement Neurocogn Disord.
- 2015 Sep;14(3):106-113.
- doi: 10.12779/dnd.2015.14.3.106
BACKGROUND AND PURPOSE: Cholinesterase inhibitors (ChEIs) are effective in Alzheimer's disease (AD) treatment. The aim of this study is 1) to find neuropsychological factors that affect the functional response to... -
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- Regulation of Gastric Electrical and Mechanical Activity by Cholinesterases in Mice
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Worth AA, Forrest AS, Peri LE, Ward SM, Hennig GW, Sanders KM
- KMID: 2381252
- J Neurogastroenterol Motil.
- 2015 Apr;21(2):200-216.
- doi: 10.5056/jnm14120
BACKGROUND/AIMS: Gastric peristalsis begins in the orad corpus and propagates to the pylorus. Directionality of peristalsis depends upon orderly generation and propagation of electrical slow waves and a frequency gradient... -
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