- Prognostic significance of programmed cell death-ligand 1 expression on immune cells and epithelialmesenchymal transition expression in patients with hepatocellular carcinoma
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Jung HI, Ahn H, Oh MH, Yun J, Lee H, Bae SH, Kim YK, Kim SY, Baek MJ, Lee MS
- KMID: 2547535
- Ann Surg Treat Res.
- 2023 Nov;105(5):297-309.
- doi: 10.4174/astr.2023.105.5.297
Purpose: Immune checkpoint inhibitors (ICIs) have been shown significant oncological improvements in several cancers. However, ICIs are still in their infancy in hepatocellular carcinoma (HCC). Programmed cell death-ligand 1 (PD-L1), tumorinfiltrating... -
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- Effectiveness and Safety of Apatinib Plus Programmed Cell Death Protein 1 Blockades for Patients with Treatment-refractory Metastatic Colorectal Cancer: A Retrospective Exploratory Study
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Li S, Zheng H, Ge Q, Xia S, Zhang K, Wang C, Wang F
- KMID: 2546896
- J Cancer Prev.
- 2023 Sep;28(3):106-114.
- doi: 10.15430/JCP.2023.28.3.106
This study aimed to investigate the efficacy and safety of apatinib plus programmed cell death protein 1 (PD-1) blockades for patients with metastatic colorectal cancer (CRC) who were refractory to... -
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- Cremastranone-Derived Homoisoflavanes Suppress the Growth of Breast Cancer Cells via Cell Cycle Arrest and Caspase-Independent Cell Death
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Choi Y, Park S, Lee S, Shin HE, Kwon S, Choi JK, Lee MH, Seo SY, Lee Y
- KMID: 2545709
- Biomol Ther.
- 2023 Sep;31(5):526-535.
- doi: 10.4062/biomolther.2023.057
Breast cancer is the most common cancer and a frequent cause of cancer-related deaths among women wordlwide. As therapeutic strategies for breast cancer have limitations, novel chemotherapeutic reagents and treatment... -
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- Different Ways to Die: Cell Death Pathways and Their Association With Spinal Cord Injury
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Guha L, Singh N, Kumar H
- KMID: 2543542
- Neurospine.
- 2023 Jun;20(2):430-448.
- doi: 10.14245/ns.2244976.488
Cell death is a systematic/nonsystematic process of cessation of normal morphology and functional properties of the cell to replace and recycle old cells with new also promoting inflammation in some... -
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- Differential Expression of NME4 in Trophoblast Stem-Like Cells and Peripheral Blood Mononuclear Cells of Normal Pregnancy and Preeclampsia
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Yu JH, Jung YJ, Kim MS, Cho SR, Kim YH
- KMID: 2541752
- J Korean Med Sci.
- 2023 Apr;38(16):e128.
- doi: 10.3346/jkms.2023.38.e128
Background: Preeclampsia (PE) is known to arise from insufficient trophoblast invasion as uterine spiral arteries lack remodeling. A significant reduction in placental perfusion induces an ischemic placental microenvironment due to... -
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- Changes and correlations of T-cell coinhibitory molecule programmed death-1 and interferon-γ in pediatric immune thrombocytopenia
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El-Gendy FM, Shehata AM, El-Kawy EAA, El-Hawy MA
- KMID: 2539778
- Clin Exp Pediatr.
- 2023 Mar;66(3):127-133.
- doi: 10.3345/cep.2022.00920
Background: Immune thrombocytopenia (ITP) is an acquired autoimmune disease characterized by abnormalities of T cells subsets. Programmed death-1 (PD-1) is a co-signaling inhibitory molecule in T cells that is involved... -
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- Proteostasis and Ribostasis Impairment as Common Cell Death Mechanisms in Neurodegenerative Diseases
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Lim SM, Nahm M, Kim SH
- KMID: 2539607
- J Clin Neurol.
- 2023 Mar;19(2):101-114.
- doi: 10.3988/jcn.2022.0379
The cellular homeostasis of proteins (proteostasis) and RNA metabolism (ribostasis) are essential for maintaining both the structure and function of the brain. However, aging, cellular stress conditions, and genetic contributions... -
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- Enhanced anti-tumor immunity of vaccine combined with anti-PD-1 antibody in a murine bladder cancer model
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Lim S, Park JH, Chang H
- KMID: 2537524
- Investig Clin Urol.
- 2023 Jan;64(1):74-81.
- doi: 10.4111/icu.20220031
Purpose: Programmed cell death protein 1 (PD-1) and ligand programmed death ligand 1 (PD-L1) are important immune-suppressive regulators in the tumor microenvironment. A vaccine-induced immune effect on tumor cells is... -
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- Vitamin D Attenuates Pain and Cartilage Destruction in OA Animals via Enhancing Autophagic Flux and Attenuating Inflammatory Cell Death
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Jhun J, Woo JS, Kwon JY, Na HS, Cho KH, Kim SA, Kim SJ, Moon SJ, Park SH, Cho ML
- KMID: 2536261
- Immune Netw.
- 2022 Aug;22(4):e34.
- doi: 10.4110/in.2022.22.e34
Osteoarthritis (OA) is the most common form of arthritis associated with ageing. Vitamin D has diverse biological effect on bone and cartilage, and observational studies have suggested it potential benefit... -
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- Signaling Role of NADPH Oxidases in ROS-Dependent Host Cell Death Induced by Pathogenic Entamoeba histolytica
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Lee YA, Sim S, Kim KA, Shin MH
- KMID: 2531459
- Korean J Parasitol.
- 2022 Jun;60(3):155-161.
- doi: 10.3347/kjp.2022.60.3.155
All living organisms are destined to die. Cells, the core of those living creatures, move toward the irresistible direction of death. The question of how to die is critical and... -
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- Immune checkpoint inhibitors for solid organ transplant recipients: clinical updates
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Kawashima S, Joachim K, Abdelrahim M, Abudayyeh A, Jhaveri KD, Murakami N
- KMID: 2531131
- Korean J Transplant.
- 2022 Jun;36(2):82-98.
- doi: 10.4285/kjt.22.0013
Transplant care continues to advance with increasing clinical experience and improvements in immunosuppressive therapy. As the population ages and long-term survival improves, transplant patient care has become more complex due... -
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- Recent Progress in Immunotherapy for Advanced Gastric Cancer
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Sohn BS
- KMID: 2530345
- J Dig Cancer Res.
- 2022 Jun;10(1):22-30.
- doi: 10.52927/jdcr.2022.10.1.22
Immune checkpoint inhibition has been established as a new treatment option for various types of carcinoma, and many clinical trials are being actively conducted as a treatment for advanced or... -
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- Evaluation of the effects of disulfiram, an alcohol-aversive agent with anti-cancer activity, on mouse bone marrow cells
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Park SR, Joo HG
- KMID: 2529398
- Korean J Physiol Pharmacol.
- 2022 May;26(3):157-164.
- doi: 10.4196/kjpp.2022.26.3.157
Disulfiram (DSF) is an aldehyde dehydrogenase inhibitor. DSF has potent anti-cancer activity for solid and hematological malignancies. Although the effects on cancer cells have been proven, there have been few... -
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- Nanozyme-Based Enhanced Cancer Immunotherapy
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Phan NM, Nguyen TL, Kim J
- KMID: 2528121
- Tissue Eng Regen Med.
- 2022 Apr;19(2):237-252.
- doi: 10.1007/s13770-022-00430-y
Catalytic nanoparticles with natural enzyme-mimicking properties, known as nanozymes, have emerged as excellent candidate materials for cancer immunotherapy. Owing to their enzymatic activities, artificial nanozymes not only serve as responsive... -
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- Histone Deacetylase as a Valuable Predictive Biomarker and Therapeutic Target in Immunotherapy for Non-Small Cell Lung Cancer
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Shin HS, Choi J, Lee J, Lee SY
- KMID: 2528215
- Cancer Res Treat.
- 2022 Apr;54(2):458-468.
- doi: 10.4143/crt.2021.425
Purpose Histone deacetylase inhibitors (HDACis) are epigenetic regulators and used clinically for hematopoietic malignancies. Recently, HDACis have received attention as a factor that modulates the immune system. In this study,... -
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- Glasgow prognostic score and combined positive score for locally advanced rectal cancer
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Feng Y, Luo J, Liu P, Liu L, Zhu Y, Cheng G, Zheng L
- KMID: 2526936
- Ann Surg Treat Res.
- 2022 Mar;102(3):153-158.
- doi: 10.4174/astr.2022.102.3.153
Purpose: This study was performed to investigate the association of Glasgow prognostic score (GPS), combined positive score (CPS), and clinicopathological characteristics of locally advanced rectal cancer. Methods: Between February 2012 and... -
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- Naegleria fowleri Induces Jurkat T Cell Death via O-deGlcNAcylation
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Lee YA, Kim KA, Shin MH
- KMID: 2522057
- Korean J Parasitol.
- 2021 Oct;59(5):501-505.
- doi: 10.3347/kjp.2021.59.5.501
The pathogenic free-living amoeba Naegleria fowleri causes primary amoebic meningoencephalitis, a fatal infection, by penetrating the nasal mucosa and migrating to the brain via the olfactory nerves. N. fowleri can... -
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- An update on immunotherapy with PD-1 and PD-L1 blockade
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Koh SA
- KMID: 2521710
- Yeungnam Univ J Med.
- 2021 Oct;38(4):308-317.
- doi: 10.12701/yujm.2021.01312
Cancer is the leading cause of death and is on the rise worldwide. Until 2010, the development of targeted treatment was mainly focused on the growth mechanisms of cancer. Since... -
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- Longitudinal Intravital Imaging of Tumor-Infiltrating Lymphocyte Motility in Breast Cancer Models
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Park I, Hong S, Seok J, Lucia SE, Song E, Kim M, Kong E, Seo H, Hwang Y, Ahn S, Kim S, Jang DH, Lee JH, Park SH, Kim P, Jo YH
- KMID: 2522097
- J Breast Cancer.
- 2021 Oct;24(5):463-473.
- doi: 10.4048/jbc.2021.24.e40
Immunoreactive dynamics of tumor-infiltrating lymphocytes (TILs) within the tumor microenvironment in breast cancer are not well understood. This study aimed to investigate the spatiotemporal cellular dynamics of TILs in breast... -
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- Apoptin gene delivery by a PAMAM dendrimer modified with a nuclear localization signal peptide as a gene carrier for brain cancer therapy
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Bae Y, Lee J, Kho C, Choi JS, Han J
- KMID: 2519409
- Korean J Physiol Pharmacol.
- 2021 Sep;25(5):467-478.
- doi: 10.4196/kjpp.2021.25.5.467
In this study, we aimed to synthesize PAMAMG3 derivatives (PAMAMG3-KRRR and PAMAMG3-HKRRR), using KRRR peptides as a nuclear localization signal and introduced histidine residues into the KRRR-grafted PAMAMG3 for delivering... -
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