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Bone Marrow Adiposity, Bone Mineral Density and Wnt/β-catenin Pathway Inhibitors Levels in Hemodialysis Patients

Wang YP, Khelifi N, Halleux Cd, Ung RV, Samson F, Gagnon C, Mac-Way F

Background: Marrow adipose tissue (MAT) is known to accumulate in patients with chronic kidney disease. This pilot study aimed to evaluate bone mineral density (BMD), MAT, visceral adipose tissue (VAT),...
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Evaluation of the effects of disulfiram, an alcohol-aversive agent with anti-cancer activity, on mouse bone marrow cells

Park SR, Joo HG

Disulfiram (DSF) is an aldehyde dehydrogenase inhibitor. DSF has potent anti-cancer activity for solid and hematological malignancies. Although the effects on cancer cells have been proven, there have been few...
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Inhibitory effects of fenbendazole, an anthelmintics, on lipopolysaccharide-activated mouse bone marrow cells

Park SR, Joo HG

Fenbendazole (FBZ) is a commonly used anthelmintic in veterinary medicine that has recently been found to have anticancer effects in humans. On the other hand, few studies have examined the...
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Analysis of the Expression and Regulation of PD-1 Protein on the Surface of Myeloid-Derived Suppressor Cells (MDSCs)

Nam S, Lee A, Lim J, Lim JS

Myeloid-derived suppressor cells (MDSCs) that are able to suppress T cell function are a heterogeneous cell population frequently observed in cancer, infection, and autoimmune disease. Immune checkpoint molecules, such as...
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Dapsone modulates lipopolysaccharide-activated bone marrow cells by inducing cell death and down-regulating tumor necrosis factor-α production

Kwon MJ, Joo HG

Dapsone, an antibiotic, has been used to cure leprosy. It has been reported that dapsone has anti-inflammatory activity in hosts; however, the anti-inflammatory mechanism of dapsone has not been fully...
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Bordetella bronchiseptica antigen enhances the production of Mycoplasma hyopneumoniae antigen-specific immunoglobulin G in mice

Yim SH, Hahn TW, Joo HG

We previously demonstrated that Bordetella (B.) bronchiseptica antigen (Ag) showed high immunostimulatory effects on mouse bone marrow cells (BMs) while Mycoplasma (M.) hyopneumoniae Ag showed low effects. The focus of...
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Changes of Gene Expression after Bone Marrow Cell Transfusion in Rats with Monocrotaline-Induced Pulmonary Hypertension

Kim KC, Lee HR, Kim SJ, Cho MS, Hong YM

Pulmonary artery hypertension (PAH) causes right ventricular failure and possibly even death by a progressive increase in pulmonary vascular resistance. Bone marrow-derived mesenchymal stem cell therapy has provided an alternative...
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The Effects of Extracellular pH on Proliferation and Differentiation of human Bone Marrow Stem Cells

Leem YH, Nam TS, Kim JH, Lee KS, Lee DH, Yun J, Chang JS

OBJECTIVES: The purpose of this study is to identify whether the change of pH affects the proliferation and the differentiation of human bone marrow stem cells (hBMSCs) and what mechanism...
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Hypoxic Treated Bone Marrow Cells Enhanced Foxp3 and IL-10 Expression in a Murine Liver Injury Model

Joo SY, Jung SO, Cho KA, Woo SY, Seoh JY, Ryu KH

  • KMID: 2049255
  • Clin Pediatr Hematol Oncol.
  • 2010 Apr;17(1):51-58.
PURPOSE: It has been reported that bone marrow (BM)-derived stem cells retain the capability of regenerating organs, as well as functioning as an immune modulator. We previously reported that liver...
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Effect of Bone Marrow Cell Collection Techniques and Donor Site Locations on In-Vitro Growth of Bone Forming Cells

Chung SM, Kim EB, Park SY, Sung MC, Youn HK, Ahn MW

PURPOSE: This study evaluated the influence of bone marrow cell collection techniques and donor site locations on the in-vitro growth of bone-forming cells. METHODS: Sixty six samples of bone marrow...
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Radioprotective effects of fucoidan on bone marrow cells: improvement of the cell survival and immunoreactivity

Byon YY, Kim MH, Yoo ES, Hwang KK, Jee Y, Shin T, Joo HG

Fucoidan is a sulfated polysaccharide purified from brown algae including Fucus vesiculosus and has a variety of biological effects including mobilization of hematopoietic progenitor cells. Recently, we demonstrated that fucoidan...
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The radioprotective effects of the hexane and ethyl acetate extracts of Callophyllis japonica in mice that undergo whole body irradiation

Kim J, Moon C, Kim H, Jeong J, Lee J, Kim J, Hyun JW, Park JW, Moon MY, Lee NH, Kim SH, Jee Y, Shin T

The radioprotective activity of extracts from the red seaweed Callophyllis (C.) japonica was investigated in mice that underwent whole-body exposure to gamma radiation. A methanol extract of C. japonica and...
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Radioprotective effects of an acidic polysaccharide of Panax ginseng on bone marrow cells

Kim HJ, Kim MH, Byon YY, Park JW, Jee Y, Joo HG

An acidic polysaccharide of Panax ginseng (APG), so called ginsan is known to have important immunomodulatory activities. It was recently reported that APG has radioprotective effects in mice but the...
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Tissue engineering of heart valves by recellularization of glutaraldehyde-fixed porcine valves using bone marrow-derived cells

Kim SS, Lim SH, Cho SW, Gwak SJ, Hong YS, Chang BC, Park MH, Song KW, Choi CY, Kim BS

  • KMID: 1094153
  • Exp Mol Med.
  • 2006 Jun;38(3):273-283.
To increase the biocompatibility and durability of glutaraldehyde (GA)-fixed valves, a biological coating with viable endothelial cells (ECs) has been proposed. However, stable EC layers have not been formed successfully...
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Comparison of Bone Marrow Stromal Cells with Fibroblasts in Wound Healing Accelerating Growth Factor Secretion

Kim SH, Han SK, Yoon TH, Kim WK

  • KMID: 2120051
  • J Korean Soc Plast Reconstr Surg.
  • 2006 Jan;33(1):1-4.
Cryopreserved fibroblast implants represent a major advancement for healing of chronic wounds. Bone marrow stromal cells, which include the mesenchymal stem cells, have a low immunity-assisted rejection and are capable...
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The Effect of Simvastatin on the Proliferation and Differentiation of Human Bone Marrow Stromal Cells

Baek KH, Lee WY, Oh KW, Tae HJ, Lee JM, Lee EJ, Han JH, Kang MI, Cha BY, Lee KW, Son HY, Kang SK

Statins have been postulated to affect the bone metabolism. Recent experimental and epidemiologic studies have suggested that statins may also have bone protective effects. This study assessed the effects of...
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Induction of Tolerance to Complete Histocompatibility Mismatched Mice Islets through the Co-transplantation of Bone Marrow Cells in a Minimal Nonmyeloablative Condition

Lee JI, Oh SH, Ahn YR, Chae HY, Lee BW, Chung JH, Min YK, Lee MS, Lee MK, Kim KW

  • KMID: 2331758
  • J Korean Diabetes Assoc.
  • 2005 Mar;29(2):103-111.
BACKGROUND: Islet transplantation(IT) is a therapeutic approach that is used to prevent the dreaded diabetes complications that occur in those patients having an insulin deficient state. However, the requirement of...
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Experimental culture condition for endothelial and their progenitor cells from CD34+ hematopoietic stem cells

Kim HO, Park KI, Shin JW, Kim MJ, Seo DH

  • KMID: 2300099
  • Korean J Blood Transfus.
  • 2004 Dec;15(2):220-230.
BACKGROUND: The concept of "neovascularization", which was first applied to describe the pathogenesis of diseases such as diabetic retinopathy or rheumatoid arthritis, has been extended to other fields of study...
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Identification of the Marker-Genes for Dioxin(2,3,7,8-tetradibenzo-p-dioxin)-Induced Immune Dysfunction by Using the High-Density Oligonucleotide Microarray

Kim JA, Lee EJ, Kim HL

  • KMID: 2166168
  • Genomics Inform.
  • 2004 Jun;2(2):75-80.
In a variety of animal species, the perinatal exposure of experimental animals to the 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) leads to the immune dysfunction, which is more severe and persistent than that caused...
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Mid-term Clinical Results of Tissue-Engineered Vascular Autografts Seeded with Autologous Bone Marrow Cells

Shin'oka T

OBJECTIVE: Prosthetic and bioprosthetic materials currently in use lack growth potential and therefore must be repeatedly replaced in pediatric patients as they develop. Tissue engineering (TE) is a new...
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