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Analysis of clinical features of adult asthma according to blood basophils and their association with cytokines in exhaled breath condensate

Shim JS, Kim MH, Cho YJ

Purpose: Although basophils are major effector cells involved in asthma, their pathophysiological role in asthma remains uncertain. In this study, we investigated the relationship between blood basophils, clinical features in...
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Basophil Activation Test Based on CD203c Expression in the Diagnosis of Fish Allergy

Imakiire R, Fujisawa T, Nagao M, Tokuda R, Hattori T, Kainuma K, Kawano Y

Purpose: The basophil activation test (BAT) has been reported to be useful for the diagnosis of various food allergies, such as allergy to peanut, but not to fish. This study...
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Dimerized, Not Monomeric, Translationally Controlled Tumor Protein Induces Basophil Activation and Mast Cell Degranulation in Chronic Urticaria

Ulambayar , Lee H, Yang EM, Park HS, Lee K, Ye YM

Translationally controlled tumor protein (TCTP) is also known as histamine releasing factor as it has the ability to activate mast cells. To investigate the role of TCTP in the pathogenesis...
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Allergy to carminic acid: in vitro evidence of involvement of protein-binding hapten

Osumi M, Yamaguchi , Sugimoto N, Suzukawa M, Arai H, Akiyama H, Nagase H, Ohta K

We previously described a rare case of anaphylaxis presumably induced by carminic acid in cochineal dye used as a food additive. In this study, highly pure carminic acid was added...
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Pollen/Fruit Syndrome: Clinical Relevance of the Cypress Pollen Allergenic Gibberellin-Regulated Protein

Sénéchal H, Keykhosravi S, Couderc R, Selva MA, Shahali Y, Aizawa T, Busnel JM, Arif R, Mercier I, Pham-Thi N, Charpin DA, Poncet P

A pollen/food-associated syndrome (PFAS) has been described between peach and cypress pollen. Cross-reactive allergens were characterized which belong to the Gibberellin-regulated protein (GRP) family, BP14 in cypress pollen and Pru...
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Causal Relationship Between Anti-TPO IgE and Chronic Urticaria by In Vitro and In Vivo Tests

Sánchez J, Sánchez A, Cardona R

PURPOSE: Immunoglobulin (Ig) E autoantibodies against thyroid antigens such as thyroid peroxidase (TPO) have been demonstrated in chronic spontaneous urticaria (CSU) patients in higher frequency than healthy subjects. However, if...
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Changes in basophil activation during immunotherapy with house dust mite and mugwort in patients with allergic rhinitis

Kim SH, Kim SH, Chung SJ, Kim JH, Lee SY, Kim BK, Lim KW, Chang YS

BACKGROUND: The basophil activation test (BAT) is a promising tool for monitoring allergen-specific immunotherapy responses. OBJECTIVE: We aimed to investigate the changes in basophil activation in response to the inhalant allergens...
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Basophils are increased and express increased levels of interleukin-4 in the parotid lesions of Kimura disease

Nonaka M, Sakitani E, Ono E, Yamamura Y, Seo Y, Shibata N, Pawankar R, Yoshihara

BACKGROUND: Kimura disease (KD) is a systemic soft-tissue disease that leads to formation of painless masses in lymph nodes, with the highest predilection for the head and neck and especially...
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Usefulness of In Vivo and In Vitro Diagnostic Tests in the Diagnosis of Hypersensitivity Reactions to Quinolones and in the Evaluation of Cross-Reactivity: A Comprehensive Study Including the Latest Quinolone Gemifloxacin

Demir S, Gelincik A, Akdeniz N, Aktas-Cetin E, Olgac M, Unal D, Ertek B, Coskun R, ColakoÄŸlu B, Deniz G, Buyukozturk S

PURPOSE: Reports evaluating diagnosis and cross reactivity of quinolone hypersensitivity have revealed contradictory results. Furthermore, there are no reports investigating the cross-reactivity between gemifloxacin (GFX) and the others. We aimed...
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The Basophil Activation Test Is Safe and Useful for Confirming Drug-Induced Anaphylaxis

Kim SY, Kim JH, Jang YS, Choi JH, Park S, Hwang YI, Jang SH, Jung KS

The basophil activation test (BAT) has been suggested as a complementary method for diagnosing drug allergies. The aim of this study was to evaluate the clinical utility of this test...
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Short-, Intermediate-, and Long-Term Changes in Basophil Reactivity Induced by Venom Immunotherapy

Rodríguez Trabado A, Cámara Hijón C, Ramos Cantariño A, Romero-Chala S, García-Trujillo JA, Fernández Pereira LM

PURPOSE: The basophil activation test (BAT) has been used to monitor venom immunotherapy (VIT) due to its high specificity. A previous study has reported a good correlation between a significant...
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Reduced Venous Blood Basophil Count and Anxious Depression in Patients with Major Depressive Disorder

Baek JH, Kim HJ, Fava M, Mischoulon D, Papakostas GI, Nierenberg A, Heo JY, Jeon HJ

OBJECTIVE: Anxious depression has a distinct neurobiology, clinical course and treatment response from non-anxious depression. Role of inflammation in anxious depression has not been examined. As an exploratory study to...
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Basophil Markers for Identification and Activation in the Indirect Basophil Activation Test by Flow Cytometry for Diagnosis of Autoimmune Urticaria

Kim Z, Choi BS, Kim JK, Won DI

BACKGROUND: The indirect basophil activation test using flow cytometry is a promising tool for autoimmune urticaria diagnosis. We aimed to identify better donor basophils (from atopic vs. non-atopic donors and...
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Chlorpheniramine-induced anaphylaxis diagnosed by basophil activation test

Lee HS, Song WJ, Lee JW, Cho YY, Park HK, Kang MG, Cho SH, Sohn SW

Chlorpheniramine is a widely prescribed H1-antihistamine for relieving urticaria or histamine-mediated allergic reactions. However, although rare, it may cause immediate hypersensitivity reactions. The diagnosis is usually made by provocation test,...
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Serum Specific IgE to Thyroid Peroxidase Activates Basophils in Aspirin Intolerant Urticaria

Shin YS, Suh DH, Yang EM, Ye YM, Park HS

Thyroid antibodies are frequently observed in urticaria patients, but their roles in urticaria are not clearly elucidated. We investigated the role of serum specific IgE to thyroid peroxidase (TPO) in...
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Successful management of severe cow's milk allergy with omalizumab treatment and CD-sens monitoring

Nilsson C, Nordvall L, Johansson , Nopp A

Food allergy is common in children and young adults and may be difficult to diagnose and is at present treated with avoidance of the food in question. The aim of...
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Oral allergy syndrome caused by crown daisy and sesame leaf

Hong GN, Kim MA, Yoon MK, Lee SH, Park HS

Oral allergy syndrome (OAS) is a subtype of food allergy composing of itching sense and edema in the oral cavity, lips, throat, pharynx, and larynx following ingestion of some fresh...
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Basophil Activation Test with Food Additives in Chronic Urticaria Patients

Kang MG, Song WJ, Park HK, Lim KH, Kim SJ, Lee SY, Kim SH, Cho SH, Min KU, Chang YS

The role of food additives in chronic urticaria (CU) is still under investigation. In this study, we aimed to explore the association between food additives and CU by using the...
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A Case of Codeine Induced Anaphylaxis via Oral Route

Yoo HS, Yang EM, Kim MA, Hwang SH, Shin YS, Ye YM, Nahm DH, Park HS

Codeine is widely prescribed in clinical settings for the relief of pain and non-productive coughs. Common adverse drug reactions to codeine include constipation, euphoria, nausea, and drowsiness. However, there have...
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Histamine-Releasing Factor and Immunoglobulins in Asthma and Allergy

Kawakami T, Kashiwakura JI, Kawakami Y

Factors that can induce the release of histamine from basophils have been studied for more than 30 years. A protein termed histamine-releasing factor (HRF) was purified and molecularly cloned in...
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