- Minoxidil Regulates Aging-Like Phenotypes in Rat Cortical Astrocytes In Vitro
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Bang M, Yang SJ, Ahn T, Han SH, Shin CY, Kwon KJ
- KMID: 2537588
- Biomol Ther.
- 2023 Jan;31(1):116-126.
- doi: 10.4062/biomolther.2022.144
Mainly due to the slanted focus on the mechanism and regulation of neuronal aging, research on astrocyte aging and its modulation during brain aging is scarce. In this study, we... -
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- Generation of Astrocyte-Specific MAOB Conditional Knockout Mouse with Minimal Tonic GABA Inhibition
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Lee JM, Sa M, An H, Kim JMJ, Kwon J, Yoon BE, Lee CJ
- KMID: 2531119
- Exp Neurobiol.
- 2022 Jun;31(3):158-172.
- doi: 10.5607/en22016
Monoamine oxidase B (MAOB) is a key enzyme for GABA production in astrocytes in several brain regions. To date, the role of astrocytic MAOB has been studied in MAOB null... -
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- Unaltered Tonic Inhibition in the Arcuate Nucleus of Diet-induced Obese Mice
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Sa M, Lee JM, Park MG, Lim J, Joseph Kim JM, Koh W, Yoon BE, Lee CJ
- KMID: 2531118
- Exp Neurobiol.
- 2022 Jun;31(3):147-157.
- doi: 10.5607/en22014
The principal inhibitory transmitter, γ-aminobutyric acid (GABA), is critical for maintaining hypothalamic homeostasis and released from neurons phasically, as well as from astrocytes tonically. Although astrocytes in the arcuate nucleus... -
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- Inhibition of lyosphosphatidic acid receptor 1 signaling in periodontal ligament stem cells reduces inflammatory paracrine effect in primary astrocyte cells
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Kim DH, Seo EJ, Kim YH, Jang IH
- KMID: 2530747
- Int J Oral Biol.
- 2022 Jun;47(2):25-31.
- doi: 10.11620/IJOB.2022.47.2.25
Lysophosphatidic acid (LPA) is a bioactive lipid messenger involved in the pathogenesis of chronic inflammation and various diseases. Recent studies have shown an association between periodontitis and neuroinflammatory diseases such... -
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- Evidence of Inflammation in Parkinson’s Disease and Its Contribution to Synucleinopathy
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Lai TT, Kim YJ, Ma Hi, Kim YE
- KMID: 2525083
- J Mov Disord.
- 2022 Jan;15(1):1-14.
- doi: 10.14802/jmd.21078
Accumulation of alpha-synuclein (αSyn) protein in neurons is a renowned pathological hallmark of Parkinson’s disease (PD). In addition, accumulating evidence indicates that activated inflammatory responses are involved in the pathogenesis... -
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- Kir4.1 is coexpressed with stemness markers in activated astrocytes in the injured brain and a Kir4.1 inhibitor BaCl 2 negatively regulates neurosphere formation in culture
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Kwon JK, Choi DJ, Yang H, Ko DW, Jou I, Park SM, Joe EH
- KMID: 2521482
- Korean J Physiol Pharmacol.
- 2021 Nov;25(6):565-574.
- doi: 10.4196/kjpp.2021.25.6.565
Astrocytes are activated in response to brain damage. Here, we found that expression of Kir4.1, a major potassium channel in astrocytes, is increased in activated astrocytes in the injured brain... -
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- Overexpression of SIRT3 Suppresses Oxidative Stress-induced Neurotoxicity and Mitochondrial Dysfunction in Dopaminergic Neuronal Cells
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Lee S, Jeon YM, Jo M, Kim HJ
- KMID: 2522147
- Exp Neurobiol.
- 2021 Oct;30(5):341-355.
- doi: 10.5607/en21021
Sirtuin 3 (SIRT3), a well-known mitochondrial deacetylase, is involved in mitochondrial function and metabolism under various stress conditions. In this study, we found that the expression of SIRT3 was markedly... -
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- Increases in GFAP immunoreactive astrocytes in the cerebellar molecular layer of young adult CBA/J mice
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Tyszkiewicz C, Pardo ID, Ritenour HN, Liu CN, Somps C
- KMID: 2521038
- Lab Anim Res.
- 2021 Sep;37(3):233-240.
- doi: 10.1186/s42826-021-00100-5
Background: CBA/J mice are standard experimental animals in auditory studies, and age-related changes in auditory pathways are well documented. However, changes in locomotion-related brain regions have not been systematically explored. Results:... -
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- The Pathological Role of Astrocytic MAOB in Parkinsonism Revealed by Genetic Ablation and Over-expression of MAOB
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An H, Heo JY, Lee CJ, Nam MH
- KMID: 2515811
- Exp Neurobiol.
- 2021 Apr;30(2):113-119.
- doi: 10.5607/en21007
The cause of Parkinson’s disease has been traditionally believed to be the dopaminergic neuronal death in the substantia nigra pars compacta (SNpc). This traditional view has been recently challenged by the... -
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- Late Passage Cultivation Induces Aged Astrocyte Phenotypes in Rat Primary Cultured Cells
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Bang M, Gonzales EL, Shin CY, Kwon KJ
- KMID: 2513482
- Biomol Ther.
- 2021 Mar;29(2):144-153.
- doi: 10.4062/biomolther.2020.175
Astrocytes play various important roles such as maintaining brain homeostasis, supporting neurons, and secreting inflammatory mediators to protect the brain cells. In aged subjects, astrocytes show diversely changed phenotypes and... -
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- Astrocyte lesions in cerebral cortex and cerebellum of dogs with congenital ortosystemic shunting
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Williams A, Gow A, Kilpatrick S, Tivers M, Lipscomb V, Smith K, Day MO, Jeffery N, Mellanby RJ
- KMID: 2502386
- J Vet Sci.
- 2020 May;21(3):e44.
- doi: 10.4142/jvs.2020.21.e44
Background: Congenital portosystemic shunt (cPSS) is one of the most common congenital disorders diagnosed in dogs. Hepatic encephalopathy (HE) is a frequent complication in dogs with a cPSS and is... -
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- Induction of GDNF and GFRα-1 Following AAV1-Rheb(S16H) Administration in the Hippocampus in vivo
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Yun D, Jeon MT, Kim HJ, Moon GJ, Lee S, Ha CM, Shin M, Kim SR
- KMID: 2500527
- Exp Neurobiol.
- 2020 Apr;29(2):164-175.
- doi: 10.5607/en19075
The activation of neurotrophic signaling pathways following the upregulation of glial cell line-derived neurotrophic factor (GDNF), a member of the transforming growth factor-β family, has a potential neuroprotective effect in... -
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- Expression of Cellular Receptors in the Ischemic Hemisphere of Mice with Increased Glucose Uptake
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Lee JS, Hong JM, Yoon BS, Son KS, Lee KE, Im DS, Park BN, An YS, Hwang DH, Park CB, Kim BG, Joe Eh
- KMID: 2500519
- Exp Neurobiol.
- 2020 Feb;29(1):70-79.
- doi: 10.5607/en.2020.29.1.70
Many previous studies have shown reduced glucose uptake in the ischemic brain. In contrast, in a permanent unilateral common carotid artery occlusion (UCCAO) mouse model, our pilot experiments using 18F-fluorodeoxyglucose... -
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- RbAp48 expression and neuronal damage in the gerbil hippocampus following 5 min of transient ischemia
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Park JH, Lee TK, Kim DW, Park CW, Park YE, Kim B, Lee JC, Lee HA, Won MH, Ahn JH
- KMID: 2470111
- Lab Anim Res.
- 2019 Aug;35(2):78-85.
- doi: 10.1186/s42826-019-0011-3
Histone-binding protein RbAp48 has been known to be involved in histone acetylation, and epigenetic alterations of histone modifications are closely associated with the pathogenesis of ischemic reperfusion injury. In the... -
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- Tenovin-1 Induces Senescence and Decreases Wound-Healing Activity in Cultured Rat Primary Astrocytes
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Bang M, Ryu O, Kim DG, Mabunga DF, Cho KS, Kim Y, Han SH, Kwon KJ, Shin CY
- KMID: 2447855
- Biomol Ther.
- 2019 May;27(3):283-289.
- doi: 10.4062/biomolther.2018.107
Brain aging induces neuropsychological changes, such as decreased memory capacity, language ability, and attention; and is also associated with neurodegenerative diseases. However, most of the studies on brain aging are... -
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- Delayed Treatment of Capsaicin Produces Partial Motor Recovery by Enhancing Dopamine Function in MPPâº-lesioned Rats via Ciliary Neurotrophic Factor
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Kim KI, Baek JY, Jeong JY, Nam JH, Park ES, Bok E, Shin WH, Chung YC, Jin BK
- KMID: 2450220
- Exp Neurobiol.
- 2019 Apr;28(2):289-299.
- doi: 10.5607/en.2019.28.2.289
Transient receptor potential vanilloid subtype 1 (TRPV1) on astrocytes prevents ongoing degeneration of nigrostriatal dopamine (DA) neurons in MPPâº-lesioned rats via ciliary neurotrophic factor (CNTF). The present study determined whether... -
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- Molecular Characterization of Primary Human Astrocytes Using Digital Gene Expression Analysis
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Kim JW, Jeong JH
- KMID: 2444199
- Korean J Neurotrauma.
- 2019 Apr;15(1):2-10.
- doi: 10.13004/kjnt.2019.15.e2
OBJECTIVE: Astrocyte dysfunctions are related to several central nervous system (CNS) pathologies. Transcriptomic profiling of human mRNAs to investigate astrocyte functions may provide the basic molecular-biological data pertaining to the... -
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- Role of Agmatine on Neuroglia in Central Nervous System Injury
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Barua S, Kim JY, Lee JE
- KMID: 2469632
- Brain Neurorehabil.
- 2019 Mar;12(1):e2.
- doi: 10.12786/bn.2019.12.e2
Recovery from central nervous system (CNS) injury, such as stroke or spinal cord injury (SCI), largely depends on axonal regeneration, and the neuronal and glial cells plasticity in the lesioned... -
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- Neuroprotective Effect of β-Lapachone in MPTP-Induced Parkinson's Disease Mouse Model: Involvement of Astroglial p-AMPK/Nrf2/HO-1 Signaling Pathways
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Park JS, Leem YH, Park JE, Kim DY, Kim HS
- KMID: 2442009
- Biomol Ther.
- 2019 Feb;27(2):178-184.
- doi: 10.4062/biomolther.2018.234
Parkinson's disease is a neurodegenerative disease characterized by the progressive loss of dopaminergic neurons within the substantia nigra pars compacta. In the present study, we investigated whether β-Lapachone (β-LAP), a... -
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- Pharmacological Dissection of Intrinsic Optical Signal Reveals a Functional Coupling between Synaptic Activity and Astrocytic Volume Transient
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Woo J, Han YE, Koh W, Won J, Park MG, An H, Lee CJ
- KMID: 2439004
- Exp Neurobiol.
- 2019 Feb;28(1):30-42.
- doi: 10.5607/en.2019.28.1.30
The neuronal activity-dependent change in the manner in which light is absorbed or scattered in brain tissue is called the intrinsic optical signal (IOS), and provides label-free, minimally invasive, and... -
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