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Effects of Asthma Medication Type on Asthma Exacerbation in a Real-World Setting

Choi YJ, Kim CH, Lee J, Byun MK, Cho JH, Park HJ

Purpose: Currently, there are multiple options for the pharmacological treatment of asthma. This study aimed to compare the effects of different asthma medications on exacerbation in a real-world setting. Materials and...
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Understanding the Mouse Model of Respiratory Allergic Diseases

Park SC

Respiratory allergic diseases, represented by allergic rhinitis and asthma, show various features due to their complex pathophysiology. Mouse models of respiratory allergic diseases replicate the characteristics of human allergic rhinitis...
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Measurement and Interpretation of Fractional Exhaled Nitric Oxide

Kwon JW

Nitric oxide is produced by the human lungs and increases in response to type 2 inflammation. The level of fractional exhaled nitric oxide (FeNO) may reflect type 2 inflammation in...
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The Clinical Efficacy of Type 2 Inflammation-Specific Agents Targeting Interleukins in Reducing Exacerbations in Severe Asthma: A Meta-Analysis

Lee J, Song JU, Kim YH

Purpose: Monoclonal antibodies against type 2 inflammatory pathways are currently promising therapeutics for severe asthma.The aim of this study was to determine how well type 2 (T2) inflammation-specific agents targeting...
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Composition of Human Breast Milk Microbiota and Its Role in Children’s Health

Notarbartolo V, Giuffrè M, Montante C, Corsello G, Carta M

Human milk contains a number of nutritional and bioactive molecules including microorganisms that constitute the so-called “Human Milk Microbiota (HMM)”. Recent studies have shown that not only bacterial but also...
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Association between Soft Drink Consumption and Asthma among Korean Adults

Lee S, Kim M

Background: Asthma is a common respiratory disease, and various factors are involved in its development. This study investigated the association between soft drink consumption and asthma among Korean adults. Methods: The...
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Status of Studies Investigating Asthma–Chronic Obstructive Pulmonary Disease Overlap in Korea: A Review

Jo YS

There is a considerable number of individuals who exhibit features of both asthma and chronic obstructive pulmonary disease (COPD), defined as asthma-COPD overlap (ACO). Many studies have reported that these...
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Environmental Factors Affecting Prevalence of Allergic Diseases in Elementary School Children in a Province

Kim H

Background: The aim of the study was to investigate the association between allergic diseases and their relating factors in elementary school children living in an urban area. Methods: A self-reported International...
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Prevalence and impact of airway diseases on clinical outcomes in idiopathic pulmonary fibrosis

Park H, Cho J, Lee J, Park YS, Lee CH, Lee SM, Yoo CG, Kim YW, Han SK, Choi SM

Background/Aims: The prevalence and effects of airway diseases, including asthma, eosinophilic bronchitis (EB), chronic obstructive pulmonary disease (COPD), and asthma-COPD overlap (ACO) have not been thoroughly studied in patients with...
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The Korean Severe Asthma Registry (KoSAR): real world research in severe asthma

Kim SH, Lee H, Park SY, Park SY, Song WJ, Kim JH, Park HW, Cho YS, Yoon HJ, on behalf of the KoSAR investigators

Severe asthma constitutes a serious health burden with significant morbidity and socioeconomic costs. The development and introduction of new biologics targeting type 2 inflammation changed the paradigm for management of...
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Soluble ACE2 and TMPRSS2 Levels in the Serum of Asthmatic Patients

Lee JH, Lee CE, Yoo Y, Shin E, An J, Park SY, Song WJ, Kwon HS, Cho YS, Moon HB, Kim TB

Background: Angiotensin-converting enzyme 2 (ACE2) and transmembrane protease serine subtype 2 (TMPRSS2) are key proteins mediating viral entry of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Although gene expressions of...
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Association Between Clinical Burden and Blood Eosinophil Counts in Asthma: Findings From a Korean Adult Asthma Cohort

Kim MY, Jo EJ, Kim S, Kim MH, Jung JW, Kim JH, Moon JY, Kwon JW, Lee JH, Park CS, Jin HJ, Shin YS, Kim SH, Cho YJ, Park JW, Cho SH, Kim TB, Park HK

Background: Some reports have suggested that the clinical and economic burdens of asthma are associated with blood eosinophil levels. The association between clinical burden and blood eosinophil counts were evaluated...
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A new perspective on cholesterol in pediatric health: association of vitamin D metabolism, respiratory diseases, and mental health problems

Hong J

Cholesterol, the main structural molecule of cell membranes, is involved in essential functions of the human body. Dyslipidemia is an established risk factor for cardiovascular diseases (CVDs) that is observed...
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Environmental management education using immersive virtual reality in asthmatic children

Kim SH, Park SH, Kang I, Song Y, Lim J, Yoon W, Yoo Y

Purpose: Awareness of environmental control is considered a major influence on the performance of asthma self-management behaviors that are involved in maintaining effective control of asthma. The aim of this...
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Principles of asthma treatment and appropriate use of new drugs

Lee EG, Rhee CK

Background: Asthma is the most common chronic respiratory disease, affecting 1% to 18% of the population worldwide. It is characterized by various respiratory symptoms, such as wheezing, shortness of breath,...
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Digital Healthcare for Airway Diseases from Personal Environmental Exposure

Park Y, Lee C, Jung JY

Digital technologies have emerged in various dimensions of human life, ranging from education to professional services to wellbeing. In particular, health products and services have expanded by the use and...
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Asthma Phenotype with Metabolic Dysfunction

Park JW

Asthma is chronic eosinophilic bronchitis with the dominancy of T helper 2 (Th2) inflammation. However, patients with asthma and metabolic dysfunction have pathogenic and pathological differences from those with Th2...
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Comparison of Two pMDIs in Adult Asthmatics: A Randomized Double-Blind Double-Dummy Clinical Trial

Nam TH, Kang SY, Lee SM, Kim TB, Lee SP

Background: Only a few studies directly compared the therapeutic efficacy and safety of two pressurized metered-dose inhalers (pMDIs) in asthma. We analyzed the asthma treatment outcomes, safety, and patient preferences...
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Tiotropium Bromide Has a More Potent Effect Than Corticosteroid in the Acute Neutrophilic Asthma Mouse Model

An TJ, Kim JH, Park CK, Yoon HK

Background: Neutrophilic asthma (NeuA) is usually resistant to corticosteroids. Tiotropium bromide (TIO) is a bronchodilator that is used as an add-on therapy to inhaled corticosteroid and long-acting β2 agonist in...
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Does the Use of Asthma-Controller Medication in Accordance with Guidelines Reduce the Incidence of Acute Exacerbations and Healthcare Costs?

Lee SY, Kim K, Park YB, Yoo KH

Background: In asthma, consistent control of chronic airway inflammation is crucial, and the use of asthma-controller medication has been emphasized. Our purpose in this study is to compare the incidence...
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