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Effect of equipotent doses of propofol and sevoflurane on endoplasmic reticulum stress during breast cancer surgery

Oh CS, Hong SW, Park S, Kwon Y, Kim SH

Background: Numerous studies suggest that intravenous propofol is superior to inhaled volatile anesthetic. This study compared the changes in the endoplasmic reticulum (ER) stress of cancer cells and lymphocytes after...
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Hydroxyzine Induces Cell Death in Triple-Negative Breast Cancer Cells via Mitochondrial Superoxide and Modulation of Jak2/STAT3 Signaling

Shakya R, Park GH, Joo SH, Shim JH, Choi JS

Treatment of triple-negative breast cancer (TNBC) has been limited due to the lack of molecular targets. In this study, we evaluated the cytotoxicity of hydroxyzine, a histamine H1 receptor antagonist...
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Gaseous signal molecule SO2 regulates autophagy through PI3K/ AKT pathway inhibits cardiomyocyte apoptosis and improves myocardial fibrosis in rats with type II diabetes

Zhao J, Wu Q, Yang T, Nie L, Liu S, Zhou J, Chen J, Jiang Z, Xiao T, Yang J, Chu C

Myocardial fibrosis is a key link in the occurrence and development of diabetic cardiomyopathy. Its etiology is complex, and the effect of drugs is not good. Cardiomyocyte apoptosis is an important...
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Neogambogic acid relieves myocardial injury induced by sepsis via p38 MAPK/NF-κB pathway

Fu W, Fang X, Wu L, Hu W, Yang T

Sepsis-associated myocardial injury, an invertible myocardial depression, is a common complication of sepsis. Neogambogic acid is an active compound in garcinia and exerts anthelmintic, anti-inflammatory, and detoxification properties. The role of...
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Arctigenin induces caspase-dependent apoptosis in FaDu human pharyngeal carcinoma cells

Kang KR, Kim JS, Lim H, Seo JY, Park JH, Chun HS, Yu SK, Kim HJ, Kim CS, Kim DK

The present study was carried out to investigate the effect of Arctigenin on cell growth and the mechanism of cell death elicited by Arctigenin were examined in FaDu human pharyngeal...
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Antitumor effects of valdecoxib on hypopharyngeal squamous carcinoma cells

Trang NTK, Yoo H

The antitumoral effects of valdecoxib (Val), an United States Food and Drug Administration-approved anti-inflammatory drug that was withdrawn due to the side effects of increased risk of cardiovascular adverse events,...
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Protective Role of Corticosterone against Hydrogen Peroxide-Induced Neuronal Cell Death in SH-SY5Y Cells

Lee C, Jang JH, Park GH

Stress breaks body balance, which can cause diverse physiological disorders and worsen preexisting diseases. However, recent studies have reported that controllable stress and overcoming from stress reinforce resilience to resist...
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Synthetic Homoisoflavane Derivatives of Cremastranone Suppress Growth of Colorectal Cancer Cells through Cell Cycle Arrest and Induction of Apoptosis

Shin HE, Lee S, Choi Y, Park S, Kwon S, Choi JK, Seo SY, Lee Y

Colorectal cancer is diagnosed as the third most prevalent cancer; thus, effective therapeutic agents are urgently required. In this study, we synthesized six homoisoflavane derivatives of cremastranone and investigated their...
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MSCs-Derived miR-150-5p-Expressing Exosomes Promote Skin Wound Healing by Activating PI3K/AKT Pathway through PTEN

Xiu C, Zheng H, Jiang M, Li J, Zhou Y, Mu L, Liu W

Background and Objectives: The goal of this study was to investigate the mechanism of mesenchymal stem cell (MSC)-derived microRNA (miR)-150-5p-expressing exosomes in promoting skin wound healing through activating PI3K/AKT pathway...
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Human Umbilical Cord-Derived Mesenchymal Stem Cells Repair SU5416-Injured Emphysema by Inhibiting Apoptosis via Rescuing VEGF-VEGFR2-AKT Pathway in Rats

Chen Q, Lv L, Zheng C, Pan H, Xu J, Lin J, Deng Z, Qian W

Background and Objectives: Chronic obstructive pulmonary disease (COPD) is a common, frequently-occurring disease and poses a major health concern. Unfortunately, there is current no effective treatment for COPD, particularly emphysema....
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Excretory-Secretory Products of Trichomonas vaginalis Cause Apoptosis in Mouse Sperm in Vitro

Keum J, Roh J, Ryu JS, Ryu KY

Excretory-secretory products (ESP) of T. vaginalis have been shown to inhibit sperm motility, viability, and functional integrity, leading to a decreased fertilization rate in vitro. This study investigated whether T....
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Anticancer effects of Ulva compressa extracts on FaDu human hypopharangeal squamous carcinoma cells in vitro

Jang JY, Jung SY, Park BR, Lee SA, Kim CS

Ulva compressa Linnaeus (UCL) is a green algae seaweed that performs photosynthesis and is used as a food material in some Asian regions including Korea. It is known to...
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Comparative histological study on the effect of tramadol abuse on the testis of juvenile and adult male albino mice

Abou Elghait 1 AT, Mostafa TM, Gameaa FK, Mohammed GK, Meligy FY, Sayed MM

As a synthetic analog of codeine, tramadol is often prescribed to treat mild to moderate pains. This study was designed to estimate and compare the histological effect of tramadol on...
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Silver Nanoparticles Exert Apoptotic Activity in Bladder Cancer 5637 Cells Through Alteration of Bax/Bcl-2 Genes Expression

Daei S, Ziamajidi N, Abbasalipourkabir R, Aminzadeh Z, Vahabirad M

Bladder cancer is defined as a urinary tract malignancy that threatens men’s and women’s health. Due to the side effects of common chemotherapies, novel therapeutic strategies are necessary to overcome...
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Anti-cancer effects of fenbendazole on 5-fluorouracil-resistant colorectal cancer cells

Park D, Lee JH, Yoon SP

Benzimidazole anthelmintic agents have been recently repurposed to overcome cancers resistant to conventional therapies. To evaluate the anti-cancer effects of benzimidazole on resistant cells, various cell death pathways were investigated...
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Benzyl Isothiocyanate-Induced Cytotoxicity via the Inhibition of Autophagy and Lysosomal Function in AGS Cells

Po WW, Choi WS, Khing TM, Lee JY, Lee JH, Bang JS, Min YS, Jeong JH, Sohn UD

Gastric adenocarcinoma is among the top causes of cancer-related death and is one of the most commonly diagnosed carcinomas worldwide. Benzyl isothiocyanate (BITC) has been reported to inhibit the gastric...
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MiR-103a-3p Contributes to the Progression of Colorectal Cancer by Regulating GREM2 Expression

Zhang Z, Zhu X

Purpose: Our research aimed to investigate the influence of miR-103a-3p on the growth and apoptosis of colorectal cancer (CRC) cells. Materials and Methods: Bioinformatics was employed to analyze differentially expressed microRNAs...
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Induction of apoptotic cell death in human bladder cancer cells by ethanol extract of Zanthoxylum schinifolium leaf, through ROS-dependent inactivation of the PI3K/Akt signaling pathway

Park C, Choi EO, Hwangbo H, Lee H, Jeong JW, Han MH, Moon SK, Yun SJ, Kim WJ, Kim GY, Hwang HJ, Choi YH

BACKGROUND/OBJECTIVES: Zanthoxylum schinifolium is traditionally used as a spice for cooking in East Asian countries. This study was undertaken to evaluate the anti-proliferative potential of ethanol extracts of Z. schinifolium...
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Human Umbilical Cord Mesenchymal Stem Cells Improve the Necrosis and Osteocyte Apoptosis in Glucocorticoid-Induced Osteonecrosis of the Femoral Head Model through Reducing the Macrophage Polarization

Tian G, Liu C, Gong Q, Yu Z, Wang H, Zhang D, Cong H

Background and Objectives: Apoptosis is an outstanding determinant of glucocorticoid (GC)-induced osteonecrosis of the femoral head (ONFH). Human umbilical cord mesenchymal stem cells (hUC-MSCs) have been demonstrated to be associated...
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The Endoplasmic Reticulum Stress Response Mediates Shikonin-Induced Apoptosis of 5-Fluorouracil–Resistant Colorectal Cancer Cells

Piao MJ, Han X, Kang KA, Madushan Fernando PDS, Lakmini Herath HMU, Hyun JW

Resistance to chemotherapeutic drugs is a significant problem in the treatment of colorectal cancer, resulting in low response rates and decreased survival. Recent studies have shown that shikonin, a naphthoquinone...
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