- Incidence and Pattern of Aminotransferase Elevation During Anti-Hypertensive Therapy With Angiotensin-II Receptor Blockers
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Choi WJ, Kim GA, Park J, Jang S, Jung WJ, Shim JJ, Park Y, Choi GH, Kim JW, Jeong SH, Jang ES
- KMID: 2532630
- J Korean Med Sci.
- 2022 Aug;37(33):e255.
- doi: 10.3346/jkms.2022.37.e255
Background: Angiotensin type II receptor blockers (ARBs) are the most widely used antihypertensive drugs. This study aimed to elucidate the likelihood and pattern of ARB-induced liver injury in a hospital-based... -
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- Class duplication prescriptions in patients taking fixed-dose combination antihypertensives
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Koo H, Lee JW, Choi HE, Je NK, Jeong KH
- KMID: 2531011
- Korean J Clin Pharm.
- 2022 Jun;32(2):125-132.
- doi: 10.24304/kjcp.2022.32.2.125
Background: Fixed-dose combinations have the advantage of improving patient compliance, but may increase the risk of duplicate prescriptions. As the use of fixed-dose combination antihypertensives increases, it is necessary to... -
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- Fimasartan Ameliorates Deteriorations in Glucose Metabolism in a High Glucose State by Regulating Skeletal Muscle and Liver Cells
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Jang YN, Lee YJ, Han YM, Kim HM, Seo HS, Jeong JH, Park SY, Jung TW
- KMID: 2530373
- Yonsei Med J.
- 2022 Jun;63(6):530-538.
- doi: 10.3349/ymj.2022.63.6.530
Purpose: Since diabetes and hypertension frequently occur together, it is thought that these conditions may have a common pathogenesis. This study was designed to evaluate the anti-diabetic function of the... -
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- Determination of candesartan or olmesartan in hypertensive patient plasma using UPLC-MS/MS
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Jeong HC, Seo YH, Gu N, Rhee MY, Shin KH
- KMID: 2525623
- Transl Clin Pharmacol.
- 2021 Dec;29(4):226-238.
- doi: 10.12793/tcp.2021.29.e21
Candesartan and olmesartan are angiotensin II receptor blockers (ARBs) used for the treatment of hypertension and heart failure. Quantitation methods for candesartan and olmesartan were developed using ultra-high performance liquid... -
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- Effect of angiotensin converting enzyme inhibitor and angiotensin II receptor blocker on the patients with sepsis
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Lee HW, Suh JK, Jang E, Lee SM
- KMID: 2513748
- Korean J Intern Med.
- 2021 Mar;36(2):371-381.
- doi: 10.3904/kjim.2019.262
Background/Aims: Inhibitors of the renin-angiotensin system, angiotensin-converting enzyme (ACE) inhibitors and angiotensin II receptor blockers (ARBs), reportedly have anti-inflammatory effects. This study assessed the association of prior use of ACE... -
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- Association Between Angiotensin II Receptor Blockers and the Risk of Lung Cancer Among Patients With Hypertension From the Korean National Health Insurance Service-National Health Screening Cohort
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Moon S, Lee HY, Jang J, Park SK
- KMID: 2511339
- J Prev Med Public Health.
- 2020 Dec;53(6):476-486.
- doi: 10.3961/jpmph.20.405
Objectives: The objective of this study was to estimate the risk of lung cancer in relation to angiotensin II receptor blocker (ARB) use among patients with hypertension from the Korean... -
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- The Relationship between Pain and Vascular Function Biomarkers in Dysmenorrheal University Students
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Njoku UC, Amadi PU, Agomuo EN, Bhebhe M
- KMID: 2506828
- Chonnam Med J.
- 2020 Sep;56(3):186-190.
- doi: 10.4068/cmj.2020.56.3.186
Our aim was to establish if the secretion of contactin 1 (CNTN-1), a widely researched pain biomarker correlates with the severity of dysmenorrhea and circulating levels of vascular cell adhesion... -
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- Pre-Transplant Angiotensin II Type 1 Receptor Antibodies and Anti-Endothelial Cell Antibodies Predict Graft Function and Allograft Rejection in a Low-Risk Kidney Transplantation Setting
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Yu S, Huh HJ, Lee KW, Park JB, Kim SJ, Huh W, Jang HR, Kwon GY, Moon HH, Kang ES
- KMID: 2502570
- Ann Lab Med.
- 2020 Sep;40(5):398-408.
- doi: 10.3343/alm.2020.40.5.398
Background: Non-HLA antibodies, anti-angiotensin II type 1 receptor antibodies (anti-AT1R) and anti-endothelial cell antibodies (AECA), are known to play a role in allograft rejection. We evaluated the role of both... -
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- Impact of Angiotensin Receptor Blockers, Beta Blockers,Calcium Channel Blockers and Thiazide Diuretics on Survivalof Ovarian Cancer Patients
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Cho MA, Jeong SY, Sohn I, Kim MS, Kang JH, Paik ES, Lee YY, Choi CH
- KMID: 2500348
- Cancer Res Treat.
- 2020 Apr;52(2):645-654.
- doi: 10.4143/crt.2019.509
Purpose We investigated the impact of four types of antihypertensive medications, angiotensin receptor blockers (ARBs), beta blockers (BBs; both selective and non-selective), calcium channel blockers (CCBs), and thiazide diuretics (TDs) on survival outcomes... -
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- Angiotensin II Type 1 Receptor Blocker, Fimasartan, Reduces Vascular Smooth Muscle Cell Senescence by Inhibiting the CYR61 Signaling Pathway
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Kim I, Park CS, Lee HY
- KMID: 2450393
- Korean Circ J.
- 2019 Jul;49(7):615-626.
- doi: 10.4070/kcj.2018.0379
BACKGROUND AND OBJECTIVES: Angiotensin II (Ang II) has been suggested to accelerate vascular senescence, however the molecular mechanism(s) remain unknown. METHODS: We cultured human coronary artery smooth muscle cells (hCSMCs) and... -
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- Sudden Intraoperative Hyperkalemia during Laparoscopic Radical Nephrectomy in a Patient with Underlying Renal Insufficiency
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Jung SH, Han YJ, Shin SH, Lee HS, Lee JY
- KMID: 2441246
- Acute Crit Care.
- 2018 Nov;33(4):271-275.
- doi: 10.4266/acc.2016.00696
We experienced a case of severe intraoperative hyperkalemia during laparoscopic radical nephrectomy in a 60-year-old male patient with renal insufficiency, whose hypertension had been managed by preoperative angiotensin II receptor... -
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- Clinical Impact of Pre-transplant Antibodies Against Angiotensin II Type I Receptor and Major Histocompatibility Complex Class I-Related Chain A in Kidney Transplant Patients
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Min JW, Lee H, Choi BS, Park CW, Yang CW, Kim YS, Choi YJ, Oh EJ, Chung BH
- KMID: 2434735
- Ann Lab Med.
- 2018 Sep;38(5):450-457.
- doi: 10.3343/alm.2018.38.5.450
BACKGROUND: Evidence of antibody-mediated injury in the absence of donor-specific HLA antibodies (HLA-DSA) has recently emerged, suggesting a role of antibodies in targeting non-HLA antigens expressed on renal allograft tissue.... -
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- Angiotensin-(1-9) ameliorates pulmonary arterial hypertension via angiotensin type II receptor
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Cha SA, Park BM, Kim SH
- KMID: 2414269
- Korean J Physiol Pharmacol.
- 2018 Jul;22(4):447-456.
- doi: 10.4196/kjpp.2018.22.4.447
Angiotensin-(1-9) [Ang-(1-9)], generated from Ang I by Ang II converting enzyme 2, has been reported to have protective effects on cardiac and vascular remodeling. However, there is no report about... -
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- Silencing MR-1 attenuates atherosclerosis in ApoE(−/−) mice induced by angiotensin II through FAK-Akt–mTOR-NF-kappaB signaling pathway
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Chen Y, Cao J, Zhao Q, Luo H, Wang Y, Dai W
- KMID: 2410102
- Korean J Physiol Pharmacol.
- 2018 Mar;22(2):127-134.
- doi: 10.4196/kjpp.2018.22.2.127
Myofibrillogenesis regulator-1 (MR-1) is a novel protein involved in cellular proliferation, migration, inflammatory reaction and signal transduction. However, little information is available on the relationship between MR-1 expression and the... -
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- Developing a multi-center clinical data mart of ACEI and ARB for real-world evidence (RWE)
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Kim HS, Lee SH, Kim TM, Kim JH
- KMID: 2434272
- Clin Hypertens.
- 2018 ;24(1):18.
- doi: 10.1186/s40885-018-0103-7
BACKGROUND: Randomized controlled trials can be expensive and time-consuming, leading to medical researchers utilizing real-world evidence (RWE) based on already-collected data. We aimed to conduct various RWE studies on angiotensin-converting... -
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- Efficacy and safety of azilsartan medoxomil, an angiotensin receptor blocker, in Korean patients with essential hypertension
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Juhasz A, Wu J, Hisada M, Tsukada T, Jeong MH
- KMID: 2434256
- Clin Hypertens.
- 2018 ;24(1):2.
- doi: 10.1186/s40885-018-0086-4
BACKGROUND: This was a phase 3, randomized, double-blind, placebo-controlled study. METHODS: Adult Korean patients with essential hypertension and a baseline mean sitting clinic systolic blood pressure (scSBP) ≥150 and ≤180 mmHg were... -
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- 24-Hour blood pressure response to lower dose (30 mg) fimasartan in Korean patients with mild to moderate essential hypertension
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Lee HY, Kim CH, Song JK, Chae SC, Jeong MH, Kim DS, Oh BH
- KMID: 2396762
- Korean J Intern Med.
- 2017 Nov;32(6):1025-1036.
- doi: 10.3904/kjim.2016.094
BACKGROUND/AIMS: Fimasartan is an angiotensin type 1 receptor blocker (ARB) which has comparable efficacy and tolerability with other ARBs. The aim of this study was to evaluate 24-hour blood pressure... -
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- Comparative effects of angiotensin II and angiotensin-(4-8) on blood pressure and ANP secretion in rats
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Phuong HT, Yu L, Park BM, Kim SH
- KMID: 2395262
- Korean J Physiol Pharmacol.
- 2017 Nov;21(6):667-674.
- doi: 10.4196/kjpp.2017.21.6.667
Angiotensin II (Ang II) is metabolized from N-terminal by aminopeptidases and from C-terminal by Ang converting enzyme (ACE) to generate several truncated angiotensin peptides (Angs). The truncated Angs have different... -
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- Sulfatase 1 mediates the inhibitory effect of angiotensin II type 2 receptor inhibitor on angiotensin II-induced hypertensive mediator expression and proliferation in vascular smooth muscle cells from spontaneously hypertensive rats
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Kim HY, Cha HJ, Kim HS
- KMID: 2400328
- Yeungnam Univ J Med.
- 2017 Jun;34(1):43-54.
- doi: 10.12701/yujm.2017.34.1.43
BACKGROUND: Extracellular sulfatases (Sulfs), sulfatase 1 (Sulf1) and sulfatase 2 (Sulf2), play a pivotal role in cell signaling by remodeling the 6-O-sulfation of heparan sulfate proteoglycans on the cell surface.... -
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- Expression of Class I and Class II a/b Histone Deacetylase is Dysregulated in Hypertensive Animal Models
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Kee HJ, Kim GR, Lin MQ, Choi SY, Ryu Y, Jin L, Piao ZH, Jeong MH
- KMID: 2385394
- Korean Circ J.
- 2017 May;47(3):392-400.
- doi: 10.4070/kcj.2016.0266
BACKGROUND AND OBJECTIVES: Dysregulation of histone deacetylase expression and enzymatic activity is associated with a number of diseases. It has been reported that protein levels of histone deacetylase (HDAC)1 and... -
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