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Combination of alpha lipoic acid and metformin supplement improve assisted reproductive technologies outcomes in polycystic ovary syndrome patients

Jannatifar R, Piroozmanesh H, Sahraei SS, Asa E

We aimed to investigating the effects of metformin (MET) in combination with alpha lipoic acid (ALA) on hormonal and biochemical parameters, in polycystic ovary syndrome (PCOS) women undergoing intracytoplasmic sperm...
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Synergistic Tumoricidal Effects of Alpha-Lipoic Acid and Radiotherapy on Human Breast Cancer Cells via HMGB1

Choi HS, Kim JH, Jang SJ, Yun JW, Kang KM, Jeong H, Ha IB, Jeong BK

Purpose Radiotherapy (RT) is one of main strategies of cancer treatment. However, some cancer cells are resistant to radiation-induced cell death, including apoptosis. Therefore, alternative approaches targeting different anti-tumor mechanisms...
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Alpha-lipoic acid protects human dopaminergic neuronal cells against hydrogen peroxide-induced cell injury by inhibiting autophagy and apoptosis

Kang KR, Kim JS, Kim TH, Seo JY, Lim H, Park JH, Yang KY, Yu SK, Kim HJ, Kim CS, Chun HS, Lee DS, Park JC, Kim DK

Alpha-lipoic acid (ALA) is a naturally occurring antioxidant and has been previously used to treat diabetes and cardiovascular disease. However, the autophagy effects of ALA against oxidative stress-induced dopaminergic neuronal...
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Insulin autoimmune syndrome associated with alpha-lipoic acid in a young woman with no concomitant disease

Lee SB, Lee MY, You JH, Kim SH, Nam JS

Insulin autoimmune syndrome (IAS) is characterized by spontaneous hypoglycemia, extremely high serum insulin levels, and high titers of autoantibodies against endogenous insulin, in the absence of exogenous insulin injection. IAS...
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alpha-Lipoic Acid Inhibits Expression of IL-8 by Suppressing Activation of MAPK, Jak/Stat, and NF-kappaB in H. pylori-Infected Gastric Epithelial AGS Cells

Choi JH, Cho SO, Kim H

The epithelial cytokine response, associated with reactive oxygen species (ROS), is important in Helicobacter pylori (H. pylori)-induced inflammation. H. pylori induces the production of ROS, which may be involved in...
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Recurrent Insulin Autoimmune Syndrome Caused by alpha-Lipoic Acid in Type 2 Diabetes

Bae SM, Bae MN, Kim EY, Kim IK, Seo MW, Shin JK, Cho SR, Jeong GH

Insulin autoimmune syndrome (IAS) is characterized by spontaneous hypoglycemia caused by insulin autoantibodies in the absence of exogenous insulin administration. Some drugs containing sulfhydryl compounds are known to initiate the...
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alpha-Lipoic acid reduced weight gain and improved the lipid profile in rats fed with high fat diet

Seo EY, Ha AW, Kim WK

  • KMID: 2313593
  • Nutr Res Pract.
  • 2012 Jun;6(3):195-200.
The purpose of this study was to investigate the effects of alpha-lipoic acid on body weight and lipid profiles in Sprague-Dawley rats fed a high fat diet (HFD). After 4...
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Alpha-Lipoic Acid Decreases Iodine Uptake in the Rat Thyroid Cell Line FRTL-5

Yim JH, Kim TY, Ruiz-Llorente S, Kim WG, Han JM, Jeon MJ, Kim WB, Shong YK

BACKGROUND AND OBJECTIVES: Alpha-lipoic acid (ALA) is a naturally occurring fatty acid with strong antioxidant properties that exerts protective effects against harmful free radical damage. The aim of the present...
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Effects of alpha-lipoic acid and L-carnosine supplementation on antioxidant activities and lipid profiles in rats

Kim MY, Kim EJ, Kim YN, Choi C, Lee BH

  • KMID: 2313547
  • Nutr Res Pract.
  • 2011 Oct;5(5):421-428.
alpha-Lipoic acid and L-carnosine are powerful antioxidants and are often used as a health supplement and as an ergogenic aid. The objective of this study was to investigate the effects...
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Effects of alpha-lipoic acid on cell proliferation and apoptosis in MDA-MB-231 human breast cells

Na MH, Seo EY, Kim WK

  • KMID: 2392040
  • Nutr Res Pract.
  • 2009 Dec;3(4):265-271.
The role that antioxidants play in the process of carcinogenesis has recently gained considerable attention. alpha-Lipoic acid, a naturally occurring disulfide molecule, is a powerful antioxidant that reportedly exerts beneficial...
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Cardioprotective Effects of Alpha-Lipoic Acid on Myocardial Reperfusion Injury: Suppression of Reactive Oxygen Species Generation and Activation of Mitogen-Activated Protein Kinase

Oh SK, Yun KH, Yoo NJ, Kim NH, Kim MS, Park BR, Jeong JW

BACKGROUND AND OBJECTIVES: Reactive oxygen species (ROS) and mitogen-activated protein (MAP) kinase play an important role in the development of myocardial reperfusion injury. In this study, we examined whether treatment...
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A case of insulin autoimmune syndrome related to alpha-lipoic acid

Chang HJ, Choi HS, Park MY, Leem SM, Jang YS, Park KS, Lee JM

  • KMID: 2257626
  • Korean J Med.
  • 2009 May;76(5):600-604.
Insulin autoimmune syndrome is characterized by spontaneous hypoglycemia, high concentrations of serum immunoreactive insulin, and the presence of autoantibodies to insulin without previous insulin injection. A 71-year-old woman with diabetes,...
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The Effect of alpha-Lipoic Acid on Proteinuria and Renal TGFbeta Expression in Obese Type 2 Diabetic Rat Model

Kang SW, Lee SJ, Kim DS, Kim TW

BACKGROUND: It is well known that renal TGFbeta expression is related to the development of diabetic nephropathy. Alpha-lipoic acid (ALA), a potent antioxidant and cofactor of mitochondrial respiratory enzymes, can...
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Effects of Alpha-lipoic Acid on SREBP-1c Expression in HepG2 Cells

Yun TS, Min AK, Kim NK, Kim MK, Cho HC, Kim HS, Hwang JS, Ryu SY, Park KG, Lee IK

BACKGROUND: Non-alcoholic fatty liver disease is common in patients with insulin resistance. Sterol regulatory element binding protein-1c (SREBP-1c) is a member of a family of transcription factors that have been...
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The Effect of Alpha-Lipoic Acid on the Protection of Epidermal Nerve Fibers and Microcapillaries in the Streptozotocin-Induced Diabetic Rats

Piao MH, Jin HY, Song SK, Kang SM, Kim SY, Park JH, Baek HS, Park TS

BACKGROUND: Diabetic neuropathy is associated with risk factors for macrovascular diseases and other microvascular complications. Alpha-lipoic acid (ALA) administration has been reported to improve metabolic abnormalities and ameliorate peripheral polyneuropathy...
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Effects of alpha-Lipoic Acid on Apoptotic Cell Death in Rat Hippocampus Following Transient Forebrain Ischemia-reperfusion Injury

Ahn HC, Song JH, Kim KS, Yoo SJ

  • KMID: 2331506
  • J Korean Soc Emerg Med.
  • 2007 Apr;18(2):134-142.
PURPOSE: The purpose of this study was to evaluate effect of alpha-lipoic acid on apoptotic cell death in rat hippocampal neuron following transient forebrain ischemia-reperfusion (I/R) injury. METHODS: The four-vessel occlusion...
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The Efficacy of alpha-lipoic Acid on the Endotoxin-induced Acute Lung Injury

Huh JW, Hong SB, Kim MJ, Lim CM, Koh Y

BACKGROUND: Oxidative stress may play an important role in the pathogenesis of endotoxin-induced acute lung injury (ALI). This study evaluated the therapeutic effect of alpha-lipoic acid, a nonenzymatic antioxidant, in...
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The Effects of Alpha-Lipoic Acid on Epidermal Nerve Preservation in the Diabetic Neuropathy of OLETF Rats

Piao MH, Park JH, Baek HS, Park TS

BACKGROUND: Alpha-Lipoic acid (ALA) administration has been reported to ameliorate some of symptoms of peripheral polyneuropathy in diabetic patients and to improve endoneurial nutritive neural blood flow and nerve conduction...
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The Comparison of Efficacy with alpha-lipoic Acid Treatment Methods in Diabetic Polyneuropathy

Lee H, Min KW, Han KA

BACKGROUND: Diabetic neuropathy represents a major health problem, as it is responsible for substantial morbidity, increased mortality, and impaired quality of life. Antioxidant treatment has been shown to prevent nerve...
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Effect of 12-week Oral Treatment with alpha-lipoic acid on the Nerve Conduction in Symptomatic Diabetic Neuropathy

Sohn TS, Lee JM, Chang SA, Son HS, Cha BY, Son HY, Lee KW, Kang SK

  • KMID: 2177741
  • J Korean Diabetes Assoc.
  • 2005 Nov;29(6):533-539.
BACKGROUND: Diabetic peripheral neuropathy is multifactorial disorder arising from hyperglycemia and insulin deficiency. It has been suggested that oxidative stress resulting from enhanced free-radical formation and defects in antioxidant defence...
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