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Serum Calprotectin Is a Potential Marker in Patients with Asthma

Lee YG, Hong Js, Lee PH, Lee Jh, Park SW, Kim DJ, Jang AS

Background: Calprotectin is the major cytosolic protein in neutrophil granulocytes. Although asthma is known to cause eosinophilic inflammation, some patients with asthma have non-eosinophilic inflammation, which is characterized by local neutrophilic...
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Potential Moracin M Prodrugs Strongly Attenuate Airway Inflammation In Vivo

Lee J, Mandava S, Ahn SH, Bae MA, So KS, Kwon KS, Kim HP

This study aims to develop new potential therapeutic moracin M prodrugs acting on lung inflammatory disorders. Potential moracin M prodrugs (KW01-KW07) were chemically synthesized to obtain potent orally active derivatives,...
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Evaluation of Human MSCs Treatment Frequency on Airway Inflammation in a Mouse Model of Acute Asthma

Hur J, Kang JY, Kim YK, Lee SY, Jeon S, Kim Y, Jung CK, Rhee CK

Background: Studies in experimental models of allergic asthma have shown that mesenchymal stem cells (MSCs) have therapeutic potential for T-helper 2 (TH2) cell-mediated inflammation. However, the mechanisms underlying these therapeutic...
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The Role of Autophagy in Eosinophilic Airway Inflammation

Lee J, Kim HS

Autophagy is a homeostatic mechanism that discards not only invading pathogens but also damaged organelles and denatured proteins via lysosomal degradation. Increasing evidence suggests a role for autophagy in inflammatory...
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Protective effect of water extract of guibi-tang against pulmonary inflammation induced by cigarette smoke and lipopolysaccharide

Shin NR, Jung TY, Seo CS, Park SW, Ko JW, Kim JC, Shin IS

Water extract of guibi-tang (GB), a traditional Chinese, Japanese, and Korean herbal medicine, is used to treat memory impairment, insomnia, and peptic ulcers. The aim of this study was to...
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Administration of Pigment Epithelium-Derived Factor Inhibits Airway Inflammation and Remodeling in Chronic OVA-Induced Mice via VEGF Suppression

Zha W, Su M, Huang M, Cai J, Du Q

PURPOSE: Pigment epithelium-derived factor (PEDF) is a recently discovered antiangiogenesis protein. PEDF possesses powerful anti-inflammatory, antioxidative, antiangiogenic, and antifibrosis properties. It has been reported that PEDF can regulate vascular endothelial...
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TRIF Deficiency does not Affect Severity of Ovalbumin-induced Airway Inflammation in Mice

Kim TH, Kim DJ, Park JH, Park JH

Allergic asthma is a chronic pulmonary inflammatory disease characterized by reversible airway obstruction, hyperresponsiveness and eosinophils infiltration. Toll-like receptors (TLRs) signaling are closely associated with asthma and have emerged as...
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Receptor Interacting Protein 2 (RIP2) Is Dispensable for OVA-Induced Airway Inflammation in Mice

Kim TH, Park YM, Ryu SW, Kim DJ, Park JH, Park JH

PURPOSE: Asthma is a pulmonary chronic inflammatory disease characterized by airway obstruction and hyperresponsiveness. Pattern recognition receptors are known to play a key role in the development of allergic diseases...
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Asian Sand Dust Enhances Allergen-Induced Th2 Allergic Inflammatory Changes and Mucin Production in BALB/c Mouse Lungs

Kang IG, Jung JH, Kim ST

PURPOSE: Recent studies have reported that Asian sand dust (ASD) has a potential risk of aggravating airway inflammation. The purpose of this study was to investigate the effect of ASD...
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A 24 kDa Excretory-Secretory Protein of Anisakis simplex Larvae Could Elicit Allergic Airway Inflammation in Mice

Park HK, Cho MK, Park MK, Kang SA, Kim YS, Kim KU, Lee MK, Ock MS, Cha HJ, Yu HS

We have reported that a 24 kDa protein (22U homologous; As22U) of Anisakis simplex larvae could elicit several Th2-related chemokine gene expressions in the intestinal epithelial cell line which means...
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Enhancement of Allergen-induced Airway Inflammation by NOX2 Deficiency

Won HY, Jang EJ, Min HJ, Hwang ES

BACKGROUND: NADPH oxidase (NOX) modulates cell proliferation, differentiation and immune response through generation of reactive oxygen species. Particularly, NOX2 is recently reported to be important for regulating Treg cell differentiation...
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Alveolar macrophages modulate allergic inflammation in a murine model of asthma

Bang BR, Chun E, Shim EJ, Lee HS, Lee SY, Cho SH, Min KU, Kim YY, Park HW

The role of alveolar macrophages (AMs) in the pathogenesis of asthma is still unknown. The aim of the present study was to investigate the effects of AM in the murine...
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Effects of Bacillus Calmette-Guerin (BCG) Vaccination according to Time Point of Administration on Asthma in a Murine Model

  • KMID: 2299527
  • Korean J Asthma Allergy Clin Immunol.
  • 2010 Dec;30(4):307-313.
BACKGROUND: Asthma is a chronic allergic disease characterized by the infiltration of eosinophils into the airway and lung. Bacille Calmette-Guerin (BCG) has been reported to be beneficial to inhibit allergic...
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The Role of Oxidative Stress in the Pathogenesis of Asthma

Cho YS, Moon HB

Oxidative stress plays a critical role in the pathogenesis of asthma. To effectively control oxidative stress in asthmatics, it is important to investigate the precise intracellular mechanism by which the...
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A Brief History of Asthma and Its Mechanisms to Modern Concepts of Disease Pathogenesis

Holgate ST

The original concept of asthma being primarily a disease of airways smooth muscle drove the development of bronchodilator drugs. However when it was realised that airway inflammation underpinned the disordered...
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Effects of Korean Red Ginseng Extracts on Airway Hyperresponsiveness and Inflammation in a Murine Asthma Model

  • KMID: 2146036
  • Korean J Asthma Allergy Clin Immunol.
  • 2010 Mar;30(1):43-49.
BACKGROUND: The morbidity associated with asthma is still high, despite improvements in understanding of the disease and the development of new drugs. Therefore, many sufferers turn to alternative or complementary...
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The Soluble Tumor Necrosis Factor-Alpha Receptor Suppresses Airway Inflammation in a Murine Model of Acute Asthma

Nam HS, Lee SY, Kim SJ, Kim JS, Kwon SS, Kim YK, Kim KH, Moon HS, Song JS, Park SH, Kim SC

PURPOSE: Tumor necrosis factor-alpha (TNF-alpha) is a proinflammatory cytokine that has been implicated in many aspects of the airway pathology in asthma. TNF-alpha blocking strategies are now being tried in...
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The Relationship between Allergic Rhinitis and Asthma: One-Airway Disease

Rha YH, Choi SH

  • KMID: 2314459
  • Pediatr Allergy Respir Dis.
  • 2007 Jun;17(2):85-96.
Allergic rhinitis (AR) and asthma are common throughout the world, with a high burden of morbidity and cost. Research and clinical experience over the years has demonstrated that AR and...
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The significance of vascular endothelial growth factor(VEGF) in children with asthma and pneumonia

Choi SH, Shim JY, Yoo MH, Kim DS, Shim JW, Jung HL, Park MS

PURPOSE: Vascular endothelial growth factor(VEGF) is a key cytokine for controlling vascular permeability and angiogenesis, which is one of the major findings in airway remodeling. However, it is not well...
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The Effect of Atopy and Airway Eosinophilic Inflammation on Exercise-Induced Bronchospasm in Asthmatics

Chae HS, Kim YJ, Song DY, Kang IJ

  • KMID: 2314285
  • Pediatr Allergy Respir Dis.
  • 2003 Jun;13(2):81-89.
PURPOSE: Exercise-induced bronchospasm (EIB) is widely prevalent in asthmatic patients. Recently, eosinophilic airway inflammation and atopy (defined as skin sensitivity to common aeroallergens) are considered to be a important factors...
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