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Application of Next Generation Sequencing in Laboratory Medicine

Zhong Y, Xu F, Wu J, Schubert J, Li MM

The rapid development of next-generation sequencing (NGS) technology, including advances in sequencing chemistry, sequencing technologies, bioinformatics, and data interpretation, has facilitated its wide clinical application in precision medicine. This review...
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Efficacy and safety of oral immunotherapy for peanut allergy: a pilot study in Singaporean children

Zhong Y, Chew JM, Tan MM, Soh JY

BACKGROUND: Peanut allergy is an increasing problem in Singapore and strict avoidance is difficult as peanut is ubiquitous in Asian cuisine. OBJECTIVE: We aimed to assess the efficacy and safety of...
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Toll-like receptor 4/nuclear factor-kappa B pathway is involved in radicular pain by encouraging spinal microglia activation and inflammatory response in a rat model of lumbar disc herniation

Zhu L, Huang Y, Hu Y, Tang Q, Zhong Y

Background: Lumbar disc herniation (LDH) is a common cause of radicular pain, but the mechanism is not clear. In this study, we investigated the engagement of toll-like receptor 4 (TLR4)...
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A Comparative Study of the Effects of Different Decellularization Methods and Genipin-Cross-Linking on the Properties of Tracheal Matrices

Zhong Y, Jiang A, Sun F, Xiao Y, Gu Y, Wu L, Zhang Y, Shi H

BACKGROUND: Different decellularization methods can affect the integrity and the biomechanical and biocompatible properties of the tracheal matrix. Natural cross-linking with genipin can be applied to improve those properties. The...
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Feasibility of Three-Dimensional Balanced Steady-State Free Precession Cine Magnetic Resonance Imaging Combined with an Image Denoising Technique to Evaluate Cardiac Function in Children with Repaired Tetralogy of Fallot

Peng Y, Su X, Hu L, Wang Q, Ouyang R, Sun A, Guo C, Yao X, Zhang Y, Wang L, Zhong Y

Objective: To investigate the feasibility of cine three-dimensional (3D) balanced steady-state free precession (b-SSFP) imaging combined with a non-local means (NLM) algorithm for image denoising in evaluating cardiac function in...
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