- Inhibition of tumor necrosis factor-alpha mRNA expression by a limited series of tetrahydroisoquinolines in mouse peritoneal macrophages
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Jung TH, Lee YS, Kang YJ, Lee BK, Ko YS, Seo HG, Chung SY, Lee DH, Yun-Choi H, Chang KC
- KMID: 1917026
- Korean J Physiol Pharmacol.
- 2000 Aug;4(4):325-331.
Tumor necrosis factor-alpha (TNF-alpha) plays important roles in inflammatory responses. Some of tetrahydroisoquinoline (THI) compounds exhibited to inhibit iNOS expression in animal studies and RAW 264.7 cells, but the action of THI on... -
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- THI 52 inhibits inducible nitric oxide synthase gene expression in RAW 264.7 cells and rat lung tissue by lipopolysaccharide
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Lee BK, Park MK, Seo HG, Yun-Choi H, Lee DH, Chang KC
- KMID: 1607084
- Korean J Physiol Pharmacol.
- 2001 Oct;5(5):443-449.
Previously we reported that THI 52 inhibits tumor necrosis factor (TNF)-alpha mRNA expression in mouse peritoneal macrophages exposed to LPS plus IFN-gamma. In the present study, the effects of THI... -
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- YS 49, a Synthetic Isoquinoline Alkaloid, Protects Sheep Pulmonary Artery Endothelial Cells from tert-butylhydroperoxide-mediated Cytotoxicity
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Chong WS, Kang SY, Kang YJ, Park MK, Lee YS, Kim HJ, Seo HG, Lee JH, Yun-Choi H, Chang KC
- KMID: 1600111
- Korean J Physiol Pharmacol.
- 2005 Oct;9(5):283-289.
Endothelium, particularly pulmonary endothelium, is predisposed to injury by reactive oxygen species (ROS) and their derivatives. Heme oxygenase (HO) has been demonstrated to provide cytoprotective effects in models of oxidant-induced... -
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- Inhibition of Inducible Nitric Oxide Synthase Expression by YS 49, a Synthetic Isoquinoline Alkaloid, in ROS 17/2.8 Cells Activated with TNF-alpha, IFN-gamma and LPS
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Kang YJ, Kang SY, Lee YS, Park MK, Kim HJ, Seo HG, Lee JH, Yun-Choi H, Chang KC
- KMID: 1611431
- Korean J Physiol Pharmacol.
- 2004 Oct;8(5):273-280.
Nitric oxide (NO) has been suggested to act as a mediator of cytokine-induced effects of turn over of bone. Activation of the inducible nitric oxide synthase (iNOS) by inflammation has... -
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- Comparison of inodilator effect of higenamine, YS49, YS51, tetra-hydroisoquinoline analogs, and dobutamine in the rat
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Chong WS, Lee YS, Kang YJ, Lee DH, Ryu JC, Yun-Choi H, Chang KC
- KMID: 1849840
- Korean J Physiol Pharmacol.
- 1998 Jun;2(3):323-330.
Tetrahydroisoquinoline (THI) alkaloids can be considered as cyclized derivatives of simple phenylethylamines. Many of them, especially with 6,7-disubstitution, demonstrate a relatively high affinity for catecholamines. Present study examines the pharmacological action of limited series... -
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- Pharmacological characterization of synthetic tetrahydroisoquinoline alkaloids, YS 51 and YS 55, on the cardiovascular system
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Chang KC, Kang YJ, Lee YS, Chong WS, Yun-Choi H, Lee DH, Ryu JC
- KMID: 2285209
- Korean J Physiol Pharmacol.
- 1998 Aug;2(4):461-469.
Tetrahydroisoquinoline (THI) alkaloids can be considered as cyclized derivatives of simple phenylethylamines, and many of them, especially with 6,7-disubstitution, demonstrate relatively high affinity for catecholamines. Two -OH groups at 6 and 7 positions... -
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